@article{wang_spectral_2003,
	title = {Spectral editing and pattern recognition methods applied to high-resolution magic-angle spinning {H}-1 nuclear magnetic resonance spectroscopy of liver tissues},
	volume = {323},
	issn = {0003-2697},
	doi = {10/bbj5hx},
	abstract = {Principal component analysis (PCA) has been applied to three nuclear magnetic resonance (NMR) spectral editing methods, namely, the Carr-Purcell-Meiboom-Gill spin-echo, diffusion editing, and skyline projection of a two-dimensional J-resolved spectrum, obtained from high-resolution magic-angle spinning NMR spectroscopy of liver tissues, to distinguish between control and hydrazine-treated rats. The effects of the toxin on rat liver biochemistry were directly observed and characterized by depleted levels of liver glycogen, choline, taurine, trimethylamine N-oxide, and glucose and by elevated levels of lipids and alanine. The highly unsaturated omega-3-type fatty acid was observed for the first time in hydrazine-treated rat liver. The contributions of the metabolites to the separation of control from dosed liver tissues varied depending on the type of spectral editing method used. We have shown that subtle changes in the metabolic profiles can be selectively amplified using a metabonomics approach based on the different NMR spectral editing techniques in conjunction with PCA. (C) 2003 Elsevier Inc. All rights reserved.},
	language = {English},
	number = {1},
	journal = {Analytical Biochemistry},
	author = {Wang, Y. L. and Bollard, M. E. and Keun, H. and Antti, H. and Beckonert, O. and Ebbels, T. M. and Lindon, J. C. and Holmes, E. and Tang, H. R. and Nicholson, J. K.},
	month = dec,
	year = {2003},
	note = {Place: San Diego
Publisher: Academic Press Inc Elsevier Science
WOS:000186822700005},
	keywords = {HRMAS H-1 NMR spectroscopy, NMR spectral editing, h-1-nmr spectroscopy, hydrazine, liver tissue, metabonomics, nmr-spectroscopy, principal components analysis, urine},
	pages = {26--32},
}

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K."],"bibdata":{"bibtype":"article","type":"article","title":"Spectral editing and pattern recognition methods applied to high-resolution magic-angle spinning H-1 nuclear magnetic resonance spectroscopy of liver tissues","volume":"323","issn":"0003-2697","doi":"10/bbj5hx","abstract":"Principal component analysis (PCA) has been applied to three nuclear magnetic resonance (NMR) spectral editing methods, namely, the Carr-Purcell-Meiboom-Gill spin-echo, diffusion editing, and skyline projection of a two-dimensional J-resolved spectrum, obtained from high-resolution magic-angle spinning NMR spectroscopy of liver tissues, to distinguish between control and hydrazine-treated rats. The effects of the toxin on rat liver biochemistry were directly observed and characterized by depleted levels of liver glycogen, choline, taurine, trimethylamine N-oxide, and glucose and by elevated levels of lipids and alanine. The highly unsaturated omega-3-type fatty acid was observed for the first time in hydrazine-treated rat liver. The contributions of the metabolites to the separation of control from dosed liver tissues varied depending on the type of spectral editing method used. We have shown that subtle changes in the metabolic profiles can be selectively amplified using a metabonomics approach based on the different NMR spectral editing techniques in conjunction with PCA. (C) 2003 Elsevier Inc. All rights reserved.","language":"English","number":"1","journal":"Analytical Biochemistry","author":[{"propositions":[],"lastnames":["Wang"],"firstnames":["Y.","L."],"suffixes":[]},{"propositions":[],"lastnames":["Bollard"],"firstnames":["M.","E."],"suffixes":[]},{"propositions":[],"lastnames":["Keun"],"firstnames":["H."],"suffixes":[]},{"propositions":[],"lastnames":["Antti"],"firstnames":["H."],"suffixes":[]},{"propositions":[],"lastnames":["Beckonert"],"firstnames":["O."],"suffixes":[]},{"propositions":[],"lastnames":["Ebbels"],"firstnames":["T.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Lindon"],"firstnames":["J.","C."],"suffixes":[]},{"propositions":[],"lastnames":["Holmes"],"firstnames":["E."],"suffixes":[]},{"propositions":[],"lastnames":["Tang"],"firstnames":["H.","R."],"suffixes":[]},{"propositions":[],"lastnames":["Nicholson"],"firstnames":["J.","K."],"suffixes":[]}],"month":"December","year":"2003","note":"Place: San Diego Publisher: Academic Press Inc Elsevier Science WOS:000186822700005","keywords":"HRMAS H-1 NMR spectroscopy, NMR spectral editing, h-1-nmr spectroscopy, hydrazine, liver tissue, metabonomics, nmr-spectroscopy, principal components analysis, urine","pages":"26–32","bibtex":"@article{wang_spectral_2003,\n\ttitle = {Spectral editing and pattern recognition methods applied to high-resolution magic-angle spinning {H}-1 nuclear magnetic resonance spectroscopy of liver tissues},\n\tvolume = {323},\n\tissn = {0003-2697},\n\tdoi = {10/bbj5hx},\n\tabstract = {Principal component analysis (PCA) has been applied to three nuclear magnetic resonance (NMR) spectral editing methods, namely, the Carr-Purcell-Meiboom-Gill spin-echo, diffusion editing, and skyline projection of a two-dimensional J-resolved spectrum, obtained from high-resolution magic-angle spinning NMR spectroscopy of liver tissues, to distinguish between control and hydrazine-treated rats. The effects of the toxin on rat liver biochemistry were directly observed and characterized by depleted levels of liver glycogen, choline, taurine, trimethylamine N-oxide, and glucose and by elevated levels of lipids and alanine. The highly unsaturated omega-3-type fatty acid was observed for the first time in hydrazine-treated rat liver. The contributions of the metabolites to the separation of control from dosed liver tissues varied depending on the type of spectral editing method used. We have shown that subtle changes in the metabolic profiles can be selectively amplified using a metabonomics approach based on the different NMR spectral editing techniques in conjunction with PCA. (C) 2003 Elsevier Inc. All rights reserved.},\n\tlanguage = {English},\n\tnumber = {1},\n\tjournal = {Analytical Biochemistry},\n\tauthor = {Wang, Y. L. and Bollard, M. E. and Keun, H. and Antti, H. and Beckonert, O. and Ebbels, T. M. and Lindon, J. C. and Holmes, E. and Tang, H. R. and Nicholson, J. K.},\n\tmonth = dec,\n\tyear = {2003},\n\tnote = {Place: San Diego\nPublisher: Academic Press Inc Elsevier Science\nWOS:000186822700005},\n\tkeywords = {HRMAS H-1 NMR spectroscopy, NMR spectral editing, h-1-nmr spectroscopy, hydrazine, liver tissue, metabonomics, nmr-spectroscopy, principal components analysis, urine},\n\tpages = {26--32},\n}\n\n\n\n","author_short":["Wang, Y. L.","Bollard, M. E.","Keun, H.","Antti, H.","Beckonert, O.","Ebbels, T. M.","Lindon, J. C.","Holmes, E.","Tang, H. R.","Nicholson, J. K."],"key":"wang_spectral_2003","id":"wang_spectral_2003","bibbaseid":"wang-bollard-keun-antti-beckonert-ebbels-lindon-holmes-etal-spectraleditingandpatternrecognitionmethodsappliedtohighresolutionmagicanglespinningh1nuclearmagneticresonancespectroscopyoflivertissues-2003","role":"author","urls":{},"keyword":["HRMAS H-1 NMR spectroscopy","NMR spectral editing","h-1-nmr spectroscopy","hydrazine","liver tissue","metabonomics","nmr-spectroscopy","principal components analysis","urine"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/zotero/upscpub","dataSources":["9cGcv2t8pRzC92kzs","fvfkWcShg3Mybjoog","Tu3jPdZyJF3j547xT","3zTPPmKj8BiTcpc6C"],"keywords":["hrmas h-1 nmr spectroscopy","nmr spectral editing","h-1-nmr spectroscopy","hydrazine","liver tissue","metabonomics","nmr-spectroscopy","principal components analysis","urine"],"search_terms":["spectral","editing","pattern","recognition","methods","applied","high","resolution","magic","angle","spinning","nuclear","magnetic","resonance","spectroscopy","liver","tissues","wang","bollard","keun","antti","beckonert","ebbels","lindon","holmes","tang","nicholson"],"title":"Spectral editing and pattern recognition methods applied to high-resolution magic-angle spinning H-1 nuclear magnetic resonance spectroscopy of liver tissues","year":2003}