Defining the role of GABA in cortical development. Wang, D. D & Kriegstein, A. R J Physiol, 587(Pt 9):1873–1879, January, 2009.
abstract   bibtex   
Of the many signals in the developing nervous system, GABA (gamma-aminobutyric acid) has been shown to be one of the earliest neurotransmitters present. Unlike in the adult, where this transmitter acts synaptically to inhibit neurons, during development, GABA can depolarize progenitor cells and their progeny due to their high intracellular chloride concentration. This early form of GABA signalling may provide the main excitatory drive for the immature cortical network and play a central role in regulating cortical development. Many features of GABA signalling are conserved in different species and are recapitulated during neurogenesis in the adult brain, demonstrating the importance of this versatile molecule in driving cortical formation. Here, we present recent evidence supporting the multiple functions of GABA during embryonic development and adult neurogenesis, from regulating progenitor proliferation to influencing the migration and maturation of newborn neurons.
@ARTICLE{Wang2009-yl,
  title    = "Defining the role of {GABA} in cortical development",
  author   = "Wang, Doris D and Kriegstein, Arnold R",
  abstract = "Of the many signals in the developing nervous system, GABA
              (gamma-aminobutyric acid) has been shown to be one of the
              earliest neurotransmitters present. Unlike in the adult, where
              this transmitter acts synaptically to inhibit neurons, during
              development, GABA can depolarize progenitor cells and their
              progeny due to their high intracellular chloride concentration.
              This early form of GABA signalling may provide the main
              excitatory drive for the immature cortical network and play a
              central role in regulating cortical development. Many features of
              GABA signalling are conserved in different species and are
              recapitulated during neurogenesis in the adult brain,
              demonstrating the importance of this versatile molecule in
              driving cortical formation. Here, we present recent evidence
              supporting the multiple functions of GABA during embryonic
              development and adult neurogenesis, from regulating progenitor
              proliferation to influencing the migration and maturation of
              newborn neurons.",
  journal  = "J Physiol",
  volume   =  587,
  number   = "Pt 9",
  pages    = "1873--1879",
  month    =  jan,
  year     =  2009,
  language = "en"
}

% The entry below contains non-ASCII chars that could not be converted
% to a LaTeX equivalent.

Downloads: 0