@article{wang_bivariate_2017,
	title = {Bivariate genomic analysis identifies a hidden locus associated with bacteria hypersensitive response in {Arabidopsis} thaliana},
	volume = {7},
	copyright = {2017 The Author(s)},
	issn = {2045-2322},
	url = {https://www.nature.com/articles/srep45281},
	doi = {10.1038/srep45281},
	abstract = {Multi-phenotype analysis has drawn increasing attention to high-throughput genomic studies, whereas only a few applications have justified the use of multivariate techniques. We applied a recently developed multi-trait analysis method on a small set of bacteria hypersensitive response phenotypes and identified a single novel locus missed by conventional single-trait genome-wide association studies. The detected locus harbors a minor allele that elevates the risk of leaf collapse response to the injection of avrRpm1-modified Pseudomonas syringae (P = 1.66e-08). Candidate gene AT3G32930 with in the detected region and its co-expressed genes showed significantly reduced expression after P. syringae interference. Our results again emphasize that multi-trait analysis should not be neglected in association studies, as the power of specific multi-trait genotype-phenotype maps might only be tractable when jointly considering multiple phenotypes.},
	language = {en},
	number = {1},
	urldate = {2026-05-19},
	journal = {Scientific Reports},
	publisher = {Nature Publishing Group},
	author = {Wang, Biao and Li, Zhuocheng and Xu, Weilin and Feng, Xiao and Wan, Qianhui and Zan, Yanjun and Sheng, Sitong and Shen, Xia},
	month = mar,
	year = {2017},
	keywords = {Plant genetics, Quantitative trait},
	pages = {45281},
}

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We applied a recently developed multi-trait analysis method on a small set of bacteria hypersensitive response phenotypes and identified a single novel locus missed by conventional single-trait genome-wide association studies. The detected locus harbors a minor allele that elevates the risk of leaf collapse response to the injection of avrRpm1-modified Pseudomonas syringae (P = 1.66e-08). Candidate gene AT3G32930 with in the detected region and its co-expressed genes showed significantly reduced expression after P. syringae interference. Our results again emphasize that multi-trait analysis should not be neglected in association studies, as the power of specific multi-trait genotype-phenotype maps might only be tractable when jointly considering multiple phenotypes.","language":"en","number":"1","urldate":"2026-05-19","journal":"Scientific Reports","publisher":"Nature Publishing Group","author":[{"propositions":[],"lastnames":["Wang"],"firstnames":["Biao"],"suffixes":[]},{"propositions":[],"lastnames":["Li"],"firstnames":["Zhuocheng"],"suffixes":[]},{"propositions":[],"lastnames":["Xu"],"firstnames":["Weilin"],"suffixes":[]},{"propositions":[],"lastnames":["Feng"],"firstnames":["Xiao"],"suffixes":[]},{"propositions":[],"lastnames":["Wan"],"firstnames":["Qianhui"],"suffixes":[]},{"propositions":[],"lastnames":["Zan"],"firstnames":["Yanjun"],"suffixes":[]},{"propositions":[],"lastnames":["Sheng"],"firstnames":["Sitong"],"suffixes":[]},{"propositions":[],"lastnames":["Shen"],"firstnames":["Xia"],"suffixes":[]}],"month":"March","year":"2017","keywords":"Plant genetics, Quantitative trait","pages":"45281","bibtex":"@article{wang_bivariate_2017,\n\ttitle = {Bivariate genomic analysis identifies a hidden locus associated with bacteria hypersensitive response in {Arabidopsis} thaliana},\n\tvolume = {7},\n\tcopyright = {2017 The Author(s)},\n\tissn = {2045-2322},\n\turl = {https://www.nature.com/articles/srep45281},\n\tdoi = {10.1038/srep45281},\n\tabstract = {Multi-phenotype analysis has drawn increasing attention to high-throughput genomic studies, whereas only a few applications have justified the use of multivariate techniques. We applied a recently developed multi-trait analysis method on a small set of bacteria hypersensitive response phenotypes and identified a single novel locus missed by conventional single-trait genome-wide association studies. The detected locus harbors a minor allele that elevates the risk of leaf collapse response to the injection of avrRpm1-modified Pseudomonas syringae (P = 1.66e-08). Candidate gene AT3G32930 with in the detected region and its co-expressed genes showed significantly reduced expression after P. syringae interference. Our results again emphasize that multi-trait analysis should not be neglected in association studies, as the power of specific multi-trait genotype-phenotype maps might only be tractable when jointly considering multiple phenotypes.},\n\tlanguage = {en},\n\tnumber = {1},\n\turldate = {2026-05-19},\n\tjournal = {Scientific Reports},\n\tpublisher = {Nature Publishing Group},\n\tauthor = {Wang, Biao and Li, Zhuocheng and Xu, Weilin and Feng, Xiao and Wan, Qianhui and Zan, Yanjun and Sheng, Sitong and Shen, Xia},\n\tmonth = mar,\n\tyear = {2017},\n\tkeywords = {Plant genetics, Quantitative trait},\n\tpages = {45281},\n}\n\n\n\n\n\n\n\n","author_short":["Wang, B.","Li, Z.","Xu, W.","Feng, X.","Wan, Q.","Zan, Y.","Sheng, S.","Shen, X."],"key":"wang_bivariate_2017","id":"wang_bivariate_2017","bibbaseid":"wang-li-xu-feng-wan-zan-sheng-shen-bivariategenomicanalysisidentifiesahiddenlocusassociatedwithbacteriahypersensitiveresponseinarabidopsisthaliana-2017","role":"author","urls":{"Paper":"https://www.nature.com/articles/srep45281"},"keyword":["Plant genetics","Quantitative trait"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/zotero/upscpub","dataSources":["9cGcv2t8pRzC92kzs"],"keywords":["plant genetics","quantitative trait"],"search_terms":["bivariate","genomic","analysis","identifies","hidden","locus","associated","bacteria","hypersensitive","response","arabidopsis","thaliana","wang","li","xu","feng","wan","zan","sheng","shen"],"title":"Bivariate genomic analysis identifies a hidden locus associated with bacteria hypersensitive response in Arabidopsis thaliana","year":2017}