Abrupt hippocampal remapping signals resolution of memory interference. Wanjia, G., Favila, S. E., Kim, G., Molitor, R. J., & Kuhl, B. A. Nature Communications, 12(1):4816, August, 2021. Number: 1 Publisher: Nature Publishing Group![Abrupt hippocampal remapping signals resolution of memory interference [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Remapping refers to a decorrelation of hippocampal representations of similar spatial environments. While it has been speculated that remapping may contribute to the resolution of episodic memory interference in humans, direct evidence is surprisingly limited. We tested this idea using high-resolution, pattern-based fMRI analyses. Here we show that activity patterns in human CA3/dentate gyrus exhibit an abrupt, temporally-specific decorrelation of highly similar memory representations that is precisely coupled with behavioral expressions of successful learning. The magnitude of this learning-related decorrelation was predicted by the amount of pattern overlap during initial stages of learning, with greater initial overlap leading to stronger decorrelation. Finally, we show that remapped activity patterns carry relatively more information about learned episodic associations compared to competing associations, further validating the learning-related significance of remapping. Collectively, these findings establish a critical link between hippocampal remapping and episodic memory interference and provide insight into why remapping occurs.
@article{wanjia_abrupt_2021,
title = {Abrupt hippocampal remapping signals resolution of memory interference},
volume = {12},
copyright = {2021 The Author(s)},
issn = {2041-1723},
url = {https://www.nature.com/articles/s41467-021-25126-0},
doi = {10.1038/s41467-021-25126-0},
abstract = {Remapping refers to a decorrelation of hippocampal representations of similar spatial environments. While it has been speculated that remapping may contribute to the resolution of episodic memory interference in humans, direct evidence is surprisingly limited. We tested this idea using high-resolution, pattern-based fMRI analyses. Here we show that activity patterns in human CA3/dentate gyrus exhibit an abrupt, temporally-specific decorrelation of highly similar memory representations that is precisely coupled with behavioral expressions of successful learning. The magnitude of this learning-related decorrelation was predicted by the amount of pattern overlap during initial stages of learning, with greater initial overlap leading to stronger decorrelation. Finally, we show that remapped activity patterns carry relatively more information about learned episodic associations compared to competing associations, further validating the learning-related significance of remapping. Collectively, these findings establish a critical link between hippocampal remapping and episodic memory interference and provide insight into why remapping occurs.},
language = {en},
number = {1},
urldate = {2023-03-05},
journal = {Nature Communications},
author = {Wanjia, Guo and Favila, Serra E. and Kim, Ghootae and Molitor, Robert J. and Kuhl, Brice A.},
month = aug,
year = {2021},
note = {Number: 1
Publisher: Nature Publishing Group},
keywords = {Cognitive neuroscience, Hippocampus, Human behaviour, Long-term memory},
pages = {4816},
file = {Full Text PDF:/home/tchaase/snap/zotero-snap/common/Zotero/storage/3I87S2CJ/Wanjia et al. - 2021 - Abrupt hippocampal remapping signals resolution of.pdf:application/pdf},
}
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