The Mtb-HIV syndemic interaction: why treating M. tuberculosis infection may be crucial for HIV-1 eradication

The Mtb-HIV syndemic interaction: why treating M. tuberculosis infection may be crucial for HIV-1 eradication. Waters, R., Ndengane, M., Abrahams, M., Diedrich, C. R, Wilkinson, R. J, & Coussens, A. K Future Virology, 15(2):101–126, Future Medicine Ltd London, UK, mar, 2020.

Paper doi abstract bibtex

Accelerated tuberculosis and AIDS progression seen in HIV-1 and Mycobacterium tuberculosis ( Mtb)-coinfected individuals indicates the important interaction between these syndemic pathogens. The immunological interaction between HIV-1 and Mtb has been largely defined by how the virus exacerbates tuberculosis disease pathogenesis. Understanding of the mechanisms by which pre-existing or subsequent Mtb infection may favor the replication, persistence and progression of HIV, is less characterized. We present a rationale for the critical consideration of ‘latent' Mtb infection in HIV-1 prevention and cure strategies. In support of this position, we review evidence of the effect of Mtb infection on HIV-1 acquisition, replication and persistence. We propose that ‘latent' Mtb infection may have considerable impact on HIV-1 pathogenesis and the continuing HIV-1 epidemic in sub-Saharan Africa.

@article{Waters2020,
abstract = {Accelerated tuberculosis and AIDS progression seen in HIV-1 and Mycobacterium tuberculosis ( Mtb)-coinfected individuals indicates the important interaction between these syndemic pathogens. The immunological interaction between HIV-1 and Mtb has been largely defined by how the virus exacerbates tuberculosis disease pathogenesis. Understanding of the mechanisms by which pre-existing or subsequent Mtb infection may favor the replication, persistence and progression of HIV, is less characterized. We present a rationale for the critical consideration of ‘latent' Mtb infection in HIV-1 prevention and cure strategies. In support of this position, we review evidence of the effect of Mtb infection on HIV-1 acquisition, replication and persistence. We propose that ‘latent' Mtb infection may have considerable impact on HIV-1 pathogenesis and the continuing HIV-1 epidemic in sub-Saharan Africa.},
author = {Waters, Robyn and Ndengane, Mthawelanga and Abrahams, Melissa-Rose and Diedrich, Collin R and Wilkinson, Robert J and Coussens, Anna K},
doi = {10.2217/fvl-2019-0069},
file = {:C$\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Waters et al. - 2020 - The Mtb-HIV syndemic interaction why treating iM. tuberculosisi infection may be crucial for HIV-1 eradication.pdf:pdf},
issn = {1746-0794},
journal = {Future Virology},
keywords = {AIDS,HIV-1 cure,OA,fund{\_}ack,granuloma,immune activation,latency,review,transmission,tuberculosis,viral expansion,viral reservoir},
mendeley-tags = {OA,fund{\_}ack,review},
month = {mar},
number = {2},
pages = {101--126},
pmid = {32273900},
publisher = {Future Medicine Ltd London, UK},
title = {{The Mtb-HIV syndemic interaction: why treating \textit{M. tuberculosis} infection may be crucial for HIV-1 eradication}},
url = {https://www.futuremedicine.com/doi/10.2217/fvl-2019-0069},
volume = {15},
year = {2020}
}

Downloads: 0

{"_id":"mCZGhqZJMuuq8mbHZ","bibbaseid":"waters-ndengane-abrahams-diedrich-wilkinson-coussens-themtbhivsyndemicinteractionwhytreatingimtuberculosisiinfectionmaybecrucialforhiv1eradication-2020","author_short":["Waters, R.","Ndengane, M.","Abrahams, M.","Diedrich, C. R","Wilkinson, R. J","Coussens, A. K"],"bibdata":{"bibtype":"article","type":"article","abstract":"Accelerated tuberculosis and AIDS progression seen in HIV-1 and Mycobacterium tuberculosis ( Mtb)-coinfected individuals indicates the important interaction between these syndemic pathogens. The immunological interaction between HIV-1 and Mtb has been largely defined by how the virus exacerbates tuberculosis disease pathogenesis. Understanding of the mechanisms by which pre-existing or subsequent Mtb infection may favor the replication, persistence and progression of HIV, is less characterized. We present a rationale for the critical consideration of ‘latent' Mtb infection in HIV-1 prevention and cure strategies. In support of this position, we review evidence of the effect of Mtb infection on HIV-1 acquisition, replication and persistence. We propose that ‘latent' Mtb infection may have considerable impact on HIV-1 pathogenesis and the continuing HIV-1 epidemic in sub-Saharan Africa.","author":[{"propositions":[],"lastnames":["Waters"],"firstnames":["Robyn"],"suffixes":[]},{"propositions":[],"lastnames":["Ndengane"],"firstnames":["Mthawelanga"],"suffixes":[]},{"propositions":[],"lastnames":["Abrahams"],"firstnames":["Melissa-Rose"],"suffixes":[]},{"propositions":[],"lastnames":["Diedrich"],"firstnames":["Collin","R"],"suffixes":[]},{"propositions":[],"lastnames":["Wilkinson"],"firstnames":["Robert","J"],"suffixes":[]},{"propositions":[],"lastnames":["Coussens"],"firstnames":["Anna","K"],"suffixes":[]}],"doi":"10.2217/fvl-2019-0069","file":":C$\\$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Waters et al. - 2020 - The Mtb-HIV syndemic interaction why treating iM. tuberculosisi infection may be crucial for HIV-1 eradication.pdf:pdf","issn":"1746-0794","journal":"Future Virology","keywords":"AIDS,HIV-1 cure,OA,fund_ack,granuloma,immune activation,latency,review,transmission,tuberculosis,viral expansion,viral reservoir","mendeley-tags":"OA,fund_ack,review","month":"mar","number":"2","pages":"101–126","pmid":"32273900","publisher":"Future Medicine Ltd London, UK","title":"The Mtb-HIV syndemic interaction: why treating M. tuberculosis infection may be crucial for HIV-1 eradication","url":"https://www.futuremedicine.com/doi/10.2217/fvl-2019-0069","volume":"15","year":"2020","bibtex":"@article{Waters2020,\r\nabstract = {Accelerated tuberculosis and AIDS progression seen in HIV-1 and Mycobacterium tuberculosis ( Mtb)-coinfected individuals indicates the important interaction between these syndemic pathogens. The immunological interaction between HIV-1 and Mtb has been largely defined by how the virus exacerbates tuberculosis disease pathogenesis. Understanding of the mechanisms by which pre-existing or subsequent Mtb infection may favor the replication, persistence and progression of HIV, is less characterized. We present a rationale for the critical consideration of ‘latent' Mtb infection in HIV-1 prevention and cure strategies. In support of this position, we review evidence of the effect of Mtb infection on HIV-1 acquisition, replication and persistence. We propose that ‘latent' Mtb infection may have considerable impact on HIV-1 pathogenesis and the continuing HIV-1 epidemic in sub-Saharan Africa.},\r\nauthor = {Waters, Robyn and Ndengane, Mthawelanga and Abrahams, Melissa-Rose and Diedrich, Collin R and Wilkinson, Robert J and Coussens, Anna K},\r\ndoi = {10.2217/fvl-2019-0069},\r\nfile = {:C$\\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Waters et al. - 2020 - The Mtb-HIV syndemic interaction why treating iM. tuberculosisi infection may be crucial for HIV-1 eradication.pdf:pdf},\r\nissn = {1746-0794},\r\njournal = {Future Virology},\r\nkeywords = {AIDS,HIV-1 cure,OA,fund{\\_}ack,granuloma,immune activation,latency,review,transmission,tuberculosis,viral expansion,viral reservoir},\r\nmendeley-tags = {OA,fund{\\_}ack,review},\r\nmonth = {mar},\r\nnumber = {2},\r\npages = {101--126},\r\npmid = {32273900},\r\npublisher = {Future Medicine Ltd London, UK},\r\ntitle = {{The Mtb-HIV syndemic interaction: why treating \\textit{M. tuberculosis} infection may be crucial for HIV-1 eradication}},\r\nurl = {https://www.futuremedicine.com/doi/10.2217/fvl-2019-0069},\r\nvolume = {15},\r\nyear = {2020}\r\n}\r\n","author_short":["Waters, R.","Ndengane, M.","Abrahams, M.","Diedrich, C. R","Wilkinson, R. J","Coussens, A. K"],"key":"Waters2020","id":"Waters2020","bibbaseid":"waters-ndengane-abrahams-diedrich-wilkinson-coussens-themtbhivsyndemicinteractionwhytreatingimtuberculosisiinfectionmaybecrucialforhiv1eradication-2020","role":"author","urls":{"Paper":"https://www.futuremedicine.com/doi/10.2217/fvl-2019-0069"},"keyword":["AIDS","HIV-1 cure","OA","fund_ack","granuloma","immune activation","latency","review","transmission","tuberculosis","viral expansion","viral reservoir"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://drive.google.com/uc?export=download&id=1-JLqZ7RwZ3VC2d6ErLGHAtOeMRS_7GCz","dataSources":["Krmt6gt9ktB2s6ARh"],"keywords":["aids","hiv-1 cure","oa","fund_ack","granuloma","immune activation","latency","review","transmission","tuberculosis","viral expansion","viral reservoir"],"search_terms":["mtb","hiv","syndemic","interaction","treating","tuberculosis","infection","crucial","hiv","eradication","waters","ndengane","abrahams","diedrich","wilkinson","coussens"],"title":"The Mtb-HIV syndemic interaction: why treating M. tuberculosis infection may be crucial for HIV-1 eradication","year":2020}