@Article{RSM:Waz2005,
  author =       "O.M. Wazni and A. Rossillo and N.F. Marrouche and E.B.
                 Saad and D.O. Martin and M. Bhargava and D. Bash and S.
                 Beheiry and M. Wexman and D. Potenza and E. Pisano and
                 R. Fanelli and A. Bonso and S. Themistoclakis and D.
                 Erciyes and W.I. Saliba and R.A. Schweikert and J.
                 Brachmann and A. Raviele and A. Natale",
  title =        "Embolic events and char formation during pulmonary
                 vein isolation in patients with atrial fibrillation:
                 impact of different anticoagulation regimens and
                 importance of intracardiac echo imaging.",
  journal =      j-JCE,
  year =         "2005",
  month =        jun,
  volume =       "16",
  number =       "6",
  pages =        "576--581",
  robnote =      "afib Thromboembolic events are important complications
                 of pulmonary vein isolation (PVI) procedures, occurring
                 in up to 2.8\% of patients. In this study, we report
                 the incidence of char formation and embolic events with
                 different anticoagulation protocols prospectively
                 changed to reduce such complication. METHODS: A total
                 of 785 patients (mean age: 54 years, 83.5\% male)
                 underwent catheter-based PVI for treatment of drug
                 refractory, symptomatic atrial fibrillation (AF). PVI
                 was performed utilizing different strategies including
                 radiofrequency (RF) using temperature control energy
                 delivery and RF using intracardiac echocardiography
                 (ICE)-guided power titration. Patients were divided
                 based on the anticoagulation protocol into three
                 groups: in group 1 (194 patients), activation
                 coagulation time (ACT) was maintained between 250 and
                 300 seconds; in group 2 (180 patients), ACT was
                 maintained between 300 and 350 seconds plus the IV
                 infusion of eptifibatide (135 microg/kg bolus + 0.5
                 microg/kg/min); and in group 3 (411 patients), ACT was
                 maintained between 350 and 400 seconds. RESULTS: Char
                 formation was detected in 69 patients of group 1, 5 of
                 group 2, and 8 of group 3. An embolic event was
                 observed in 7 patients of group 1, 3 of group 2, and 2
                 of group 3 (P = 0.01; group 1 vs group 3). Higher
                 degree of anticoagulation with heparin was associated
                 with a reduced incidence of embolic events even after
                 removing the patients undergoing ICE-guided ablation (P
                 = 0.04). CONCLUSION: More aggressive anticoagulation
                 with heparin reduced periprocedural embolic events. The
                 use of platelet inhibition does not have incremental
                 beneficial effect. None of the anticoagulation protocol
                 abolished char formation.",
  bibdate =      "Thu Jun 28 00:49:02 2007",
}

{"_id":"a8dEdjeHwTsYQBTPn","bibbaseid":"wazni-rossillo-marrouche-saad-martin-bhargava-bash-beheiry-etal-emboliceventsandcharformationduringpulmonaryveinisolationinpatientswithatrialfibrillationimpactofdifferentanticoagulationregimensandimportanceofintracardiacechoimaging-2005","downloads":0,"creationDate":"2016-07-01T21:38:42.800Z","title":"Embolic events and char formation during pulmonary vein isolation in patients with atrial fibrillation: impact of different anticoagulation regimens and importance of intracardiac echo imaging.","author_short":["Wazni, O.","Rossillo, A.","Marrouche, N.","Saad, E.","Martin, D.","Bhargava, M.","Bash, D.","Beheiry, S.","Wexman, M.","Potenza, D.","Pisano, E.","Fanelli, R.","Bonso, A.","Themistoclakis, S.","Erciyes, D.","Saliba, W.","Schweikert, R.","Brachmann, J.","Raviele, A.","Natale, A."],"year":2005,"bibtype":"article","biburl":"http://www.sci.utah.edu/~macleod/Bibtex/biglit.bib","bibdata":{"bibtype":"article","type":"article","author":[{"firstnames":["O.M."],"propositions":[],"lastnames":["Wazni"],"suffixes":[]},{"firstnames":["A."],"propositions":[],"lastnames":["Rossillo"],"suffixes":[]},{"firstnames":["N.F."],"propositions":[],"lastnames":["Marrouche"],"suffixes":[]},{"firstnames":["E.B."],"propositions":[],"lastnames":["Saad"],"suffixes":[]},{"firstnames":["D.O."],"propositions":[],"lastnames":["Martin"],"suffixes":[]},{"firstnames":["M."],"propositions":[],"lastnames":["Bhargava"],"suffixes":[]},{"firstnames":["D."],"propositions":[],"lastnames":["Bash"],"suffixes":[]},{"firstnames":["S."],"propositions":[],"lastnames":["Beheiry"],"suffixes":[]},{"firstnames":["M."],"propositions":[],"lastnames":["Wexman"],"suffixes":[]},{"firstnames":["D."],"propositions":[],"lastnames":["Potenza"],"suffixes":[]},{"firstnames":["E."],"propositions":[],"lastnames":["Pisano"],"suffixes":[]},{"firstnames":["R."],"propositions":[],"lastnames":["Fanelli"],"suffixes":[]},{"firstnames":["A."],"propositions":[],"lastnames":["Bonso"],"suffixes":[]},{"firstnames":["S."],"propositions":[],"lastnames":["Themistoclakis"],"suffixes":[]},{"firstnames":["D."],"propositions":[],"lastnames":["Erciyes"],"suffixes":[]},{"firstnames":["W.I."],"propositions":[],"lastnames":["Saliba"],"suffixes":[]},{"firstnames":["R.A."],"propositions":[],"lastnames":["Schweikert"],"suffixes":[]},{"firstnames":["J."],"propositions":[],"lastnames":["Brachmann"],"suffixes":[]},{"firstnames":["A."],"propositions":[],"lastnames":["Raviele"],"suffixes":[]},{"firstnames":["A."],"propositions":[],"lastnames":["Natale"],"suffixes":[]}],"title":"Embolic events and char formation during pulmonary vein isolation in patients with atrial fibrillation: impact of different anticoagulation regimens and importance of intracardiac echo imaging.","journal":"j-JCE","year":"2005","month":"June","volume":"16","number":"6","pages":"576--581","robnote":"afib Thromboembolic events are important complications of pulmonary vein isolation (PVI) procedures, occurring in up to 2.8% of patients. In this study, we report the incidence of char formation and embolic events with different anticoagulation protocols prospectively changed to reduce such complication. METHODS: A total of 785 patients (mean age: 54 years, 83.5% male) underwent catheter-based PVI for treatment of drug refractory, symptomatic atrial fibrillation (AF). PVI was performed utilizing different strategies including radiofrequency (RF) using temperature control energy delivery and RF using intracardiac echocardiography (ICE)-guided power titration. Patients were divided based on the anticoagulation protocol into three groups: in group 1 (194 patients), activation coagulation time (ACT) was maintained between 250 and 300 seconds; in group 2 (180 patients), ACT was maintained between 300 and 350 seconds plus the IV infusion of eptifibatide (135 microg/kg bolus + 0.5 microg/kg/min); and in group 3 (411 patients), ACT was maintained between 350 and 400 seconds. RESULTS: Char formation was detected in 69 patients of group 1, 5 of group 2, and 8 of group 3. An embolic event was observed in 7 patients of group 1, 3 of group 2, and 2 of group 3 (P = 0.01; group 1 vs group 3). Higher degree of anticoagulation with heparin was associated with a reduced incidence of embolic events even after removing the patients undergoing ICE-guided ablation (P = 0.04). CONCLUSION: More aggressive anticoagulation with heparin reduced periprocedural embolic events. The use of platelet inhibition does not have incremental beneficial effect. None of the anticoagulation protocol abolished char formation.","bibdate":"Thu Jun 28 00:49:02 2007","bibtex":"@Article{RSM:Waz2005,\n author = \"O.M. Wazni and A. Rossillo and N.F. Marrouche and E.B.\n Saad and D.O. Martin and M. Bhargava and D. Bash and S.\n Beheiry and M. Wexman and D. Potenza and E. Pisano and\n R. Fanelli and A. Bonso and S. Themistoclakis and D.\n Erciyes and W.I. Saliba and R.A. Schweikert and J.\n Brachmann and A. Raviele and A. Natale\",\n title = \"Embolic events and char formation during pulmonary\n vein isolation in patients with atrial fibrillation:\n impact of different anticoagulation regimens and\n importance of intracardiac echo imaging.\",\n journal = j-JCE,\n year = \"2005\",\n month = jun,\n volume = \"16\",\n number = \"6\",\n pages = \"576--581\",\n robnote = \"afib Thromboembolic events are important complications\n of pulmonary vein isolation (PVI) procedures, occurring\n in up to 2.8\\% of patients. In this study, we report\n the incidence of char formation and embolic events with\n different anticoagulation protocols prospectively\n changed to reduce such complication. METHODS: A total\n of 785 patients (mean age: 54 years, 83.5\\% male)\n underwent catheter-based PVI for treatment of drug\n refractory, symptomatic atrial fibrillation (AF). PVI\n was performed utilizing different strategies including\n radiofrequency (RF) using temperature control energy\n delivery and RF using intracardiac echocardiography\n (ICE)-guided power titration. Patients were divided\n based on the anticoagulation protocol into three\n groups: in group 1 (194 patients), activation\n coagulation time (ACT) was maintained between 250 and\n 300 seconds; in group 2 (180 patients), ACT was\n maintained between 300 and 350 seconds plus the IV\n infusion of eptifibatide (135 microg/kg bolus + 0.5\n microg/kg/min); and in group 3 (411 patients), ACT was\n maintained between 350 and 400 seconds. RESULTS: Char\n formation was detected in 69 patients of group 1, 5 of\n group 2, and 8 of group 3. An embolic event was\n observed in 7 patients of group 1, 3 of group 2, and 2\n of group 3 (P = 0.01; group 1 vs group 3). Higher\n degree of anticoagulation with heparin was associated\n with a reduced incidence of embolic events even after\n removing the patients undergoing ICE-guided ablation (P\n = 0.04). CONCLUSION: More aggressive anticoagulation\n with heparin reduced periprocedural embolic events. The\n use of platelet inhibition does not have incremental\n beneficial effect. None of the anticoagulation protocol\n abolished char formation.\",\n bibdate = \"Thu Jun 28 00:49:02 2007\",\n}\n\n","author_short":["Wazni, O.","Rossillo, A.","Marrouche, N.","Saad, E.","Martin, D.","Bhargava, M.","Bash, D.","Beheiry, S.","Wexman, M.","Potenza, D.","Pisano, E.","Fanelli, R.","Bonso, A.","Themistoclakis, S.","Erciyes, D.","Saliba, W.","Schweikert, R.","Brachmann, J.","Raviele, A.","Natale, A."],"key":"RSM:Waz2005","id":"RSM:Waz2005","bibbaseid":"wazni-rossillo-marrouche-saad-martin-bhargava-bash-beheiry-etal-emboliceventsandcharformationduringpulmonaryveinisolationinpatientswithatrialfibrillationimpactofdifferentanticoagulationregimensandimportanceofintracardiacechoimaging-2005","role":"author","urls":{},"downloads":0,"html":""},"search_terms":["embolic","events","char","formation","during","pulmonary","vein","isolation","patients","atrial","fibrillation","impact","different","anticoagulation","regimens","importance","intracardiac","echo","imaging","wazni","rossillo","marrouche","saad","martin","bhargava","bash","beheiry","wexman","potenza","pisano","fanelli","bonso","themistoclakis","erciyes","saliba","schweikert","brachmann","raviele","natale"],"keywords":[],"authorIDs":[],"dataSources":["5HG3Kp8zRwDd7FotB"]}