Compromised cerebral blood-flow reactivity is a predictor of stroke in patients with symptomatic carotid-artery occlusive disease. Webster, M., Makaroun, M., Steed, D., Smith, H., Johnson, D., & Yonas, H JOURNAL OF VASCULAR SURGERY, 21(2):338--345, February, 1995. abstract bibtex Purpose: The purpose of this study was to determine whether the hemodynamic consequences of extracranial carotid disease correlate with the risk of subsequent cerebral infarction. Methods: In 95 patients with symptoms who had greater than or equal to 70% stenosis (31 patients) or who had occlusion (64 patients) of the ipsilateral carotid artery, cerebral blood how was measured by the stable xenon/computed tomography technique both at baseline and after vasodilatory challenge with intravenous acetazolamide. Patients were stratified into group 1, 43 patients with no more than a 5% decrease in flow in any vascular territory, and group 2, 52 patients with greater than a 5% decrease in one or more vascular territories after an acetazolamide challenge. Results: In group 2, 15 (28.9%) of 52 patients had a new stroke, but only one (2.3%) of 43 patients in group 1 did (p = 0.0005). Of patients with total carotid occlusion 10 (26%) of 38 in group 2 and none (0%) of 26 in group 1 had a new stroke (p = 0.003). Of patients with greater than or equal to 70% stenosis, five (36%) of 14 in group 2 and only one (6%) of 17 in group 1 had a stroke (p = 0.067). Conclusion: The loss of cerebral reactivity in patients with symptoms who had greater than or equal to 70% carotid stenosis or occlusion is an important predictor of impending cerebral infarction.
@article{webster_compromised_1995,
title = {Compromised cerebral blood-flow reactivity is a predictor of stroke in patients with symptomatic carotid-artery occlusive disease},
volume = {21},
issn = {0741-5214},
abstract = {Purpose: The purpose of this study was to determine whether the hemodynamic consequences of extracranial carotid disease correlate with the risk of subsequent cerebral infarction.
Methods: In 95 patients with symptoms who had greater than or equal to 70\% stenosis (31 patients) or who had occlusion (64 patients) of the ipsilateral carotid artery, cerebral blood how was measured by the stable xenon/computed tomography technique both at baseline and after vasodilatory challenge with intravenous acetazolamide. Patients were stratified into group 1, 43 patients with no more than a 5\% decrease in flow in any vascular territory, and group 2, 52 patients with greater than a 5\% decrease in one or more vascular territories after an acetazolamide challenge.
Results: In group 2, 15 (28.9\%) of 52 patients had a new stroke, but only one (2.3\%) of 43 patients in group 1 did (p = 0.0005). Of patients with total carotid occlusion 10 (26\%) of 38 in group 2 and none (0\%) of 26 in group 1 had a new stroke (p = 0.003). Of patients with greater than or equal to 70\% stenosis, five (36\%) of 14 in group 2 and only one (6\%) of 17 in group 1 had a stroke (p = 0.067).
Conclusion: The loss of cerebral reactivity in patients with symptoms who had greater than or equal to 70\% carotid stenosis or occlusion is an important predictor of impending cerebral infarction.},
number = {2},
journal = {JOURNAL OF VASCULAR SURGERY},
author = {Webster, MW and Makaroun, MS and Steed, DL and Smith, HA and Johnson, DW and Yonas, H},
month = feb,
year = {1995},
keywords = {CVR, stenosis, acetazolamide, stroke},
pages = {338--345},
file = {ISI Web of Knowledge [v.4.4] - Web of Science:/Users/nickb/Zotero/storage/MR83WTTF/CitedFullRecord.html:text/html;webster1995.pdf:/Users/nickb/Zotero/storage/4XSXXZMZ/webster1995.pdf:application/pdf}
}
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{"_id":"4ehLnY8wjwSTHLYCa","bibbaseid":"webster-makaroun-steed-smith-johnson-yonas-compromisedcerebralbloodflowreactivityisapredictorofstrokeinpatientswithsymptomaticcarotidarteryocclusivedisease-1995","downloads":0,"creationDate":"2017-07-20T09:27:29.457Z","title":"Compromised cerebral blood-flow reactivity is a predictor of stroke in patients with symptomatic carotid-artery occlusive disease","author_short":["Webster, M.","Makaroun, M.","Steed, D.","Smith, H.","Johnson, D.","Yonas, H"],"year":1995,"bibtype":"article","biburl":"https://users.fmrib.ox.ac.uk/~nickb/ExportedItemsLge.bib","bibdata":{"bibtype":"article","type":"article","title":"Compromised cerebral blood-flow reactivity is a predictor of stroke in patients with symptomatic carotid-artery occlusive disease","volume":"21","issn":"0741-5214","abstract":"Purpose: The purpose of this study was to determine whether the hemodynamic consequences of extracranial carotid disease correlate with the risk of subsequent cerebral infarction. Methods: In 95 patients with symptoms who had greater than or equal to 70% stenosis (31 patients) or who had occlusion (64 patients) of the ipsilateral carotid artery, cerebral blood how was measured by the stable xenon/computed tomography technique both at baseline and after vasodilatory challenge with intravenous acetazolamide. Patients were stratified into group 1, 43 patients with no more than a 5% decrease in flow in any vascular territory, and group 2, 52 patients with greater than a 5% decrease in one or more vascular territories after an acetazolamide challenge. Results: In group 2, 15 (28.9%) of 52 patients had a new stroke, but only one (2.3%) of 43 patients in group 1 did (p = 0.0005). Of patients with total carotid occlusion 10 (26%) of 38 in group 2 and none (0%) of 26 in group 1 had a new stroke (p = 0.003). Of patients with greater than or equal to 70% stenosis, five (36%) of 14 in group 2 and only one (6%) of 17 in group 1 had a stroke (p = 0.067). Conclusion: The loss of cerebral reactivity in patients with symptoms who had greater than or equal to 70% carotid stenosis or occlusion is an important predictor of impending cerebral infarction.","number":"2","journal":"JOURNAL OF VASCULAR SURGERY","author":[{"propositions":[],"lastnames":["Webster"],"firstnames":["MW"],"suffixes":[]},{"propositions":[],"lastnames":["Makaroun"],"firstnames":["MS"],"suffixes":[]},{"propositions":[],"lastnames":["Steed"],"firstnames":["DL"],"suffixes":[]},{"propositions":[],"lastnames":["Smith"],"firstnames":["HA"],"suffixes":[]},{"propositions":[],"lastnames":["Johnson"],"firstnames":["DW"],"suffixes":[]},{"propositions":[],"lastnames":["Yonas"],"firstnames":["H"],"suffixes":[]}],"month":"February","year":"1995","keywords":"CVR, stenosis, acetazolamide, stroke","pages":"338--345","file":"ISI Web of Knowledge [v.4.4] - Web of Science:/Users/nickb/Zotero/storage/MR83WTTF/CitedFullRecord.html:text/html;webster1995.pdf:/Users/nickb/Zotero/storage/4XSXXZMZ/webster1995.pdf:application/pdf","bibtex":"@article{webster_compromised_1995,\n\ttitle = {Compromised cerebral blood-flow reactivity is a predictor of stroke in patients with symptomatic carotid-artery occlusive disease},\n\tvolume = {21},\n\tissn = {0741-5214},\n\tabstract = {Purpose: The purpose of this study was to determine whether the hemodynamic consequences of extracranial carotid disease correlate with the risk of subsequent cerebral infarction.\n\nMethods: In 95 patients with symptoms who had greater than or equal to 70\\% stenosis (31 patients) or who had occlusion (64 patients) of the ipsilateral carotid artery, cerebral blood how was measured by the stable xenon/computed tomography technique both at baseline and after vasodilatory challenge with intravenous acetazolamide. Patients were stratified into group 1, 43 patients with no more than a 5\\% decrease in flow in any vascular territory, and group 2, 52 patients with greater than a 5\\% decrease in one or more vascular territories after an acetazolamide challenge.\n\nResults: In group 2, 15 (28.9\\%) of 52 patients had a new stroke, but only one (2.3\\%) of 43 patients in group 1 did (p = 0.0005). Of patients with total carotid occlusion 10 (26\\%) of 38 in group 2 and none (0\\%) of 26 in group 1 had a new stroke (p = 0.003). Of patients with greater than or equal to 70\\% stenosis, five (36\\%) of 14 in group 2 and only one (6\\%) of 17 in group 1 had a stroke (p = 0.067).\n\nConclusion: The loss of cerebral reactivity in patients with symptoms who had greater than or equal to 70\\% carotid stenosis or occlusion is an important predictor of impending cerebral infarction.},\n\tnumber = {2},\n\tjournal = {JOURNAL OF VASCULAR SURGERY},\n\tauthor = {Webster, MW and Makaroun, MS and Steed, DL and Smith, HA and Johnson, DW and Yonas, H},\n\tmonth = feb,\n\tyear = {1995},\n\tkeywords = {CVR, stenosis, acetazolamide, stroke},\n\tpages = {338--345},\n\tfile = {ISI Web of Knowledge [v.4.4] - Web of Science:/Users/nickb/Zotero/storage/MR83WTTF/CitedFullRecord.html:text/html;webster1995.pdf:/Users/nickb/Zotero/storage/4XSXXZMZ/webster1995.pdf:application/pdf}\n}\n\n","author_short":["Webster, M.","Makaroun, M.","Steed, D.","Smith, H.","Johnson, D.","Yonas, H"],"key":"webster_compromised_1995","id":"webster_compromised_1995","bibbaseid":"webster-makaroun-steed-smith-johnson-yonas-compromisedcerebralbloodflowreactivityisapredictorofstrokeinpatientswithsymptomaticcarotidarteryocclusivedisease-1995","role":"author","urls":{},"keyword":["CVR","stenosis","acetazolamide","stroke"],"downloads":0,"html":""},"search_terms":["compromised","cerebral","blood","flow","reactivity","predictor","stroke","patients","symptomatic","carotid","artery","occlusive","disease","webster","makaroun","steed","smith","johnson","yonas"],"keywords":["cvr","stenosis","acetazolamide","stroke"],"authorIDs":[],"dataSources":["ZnSCiZ543imjXQzRu"]}