Gyromagnetic Imaging: Dynamic Optical Contrast Using Gold Nanostars with Magnetic Cores. Wei, Q., Song, H., Leonov, A. P., Hale, J. A., Oh, D., Ong, Q. K., Ritchie, K., & Wei, A. Journal of the American Chemical Society, 131(28):9728--9734, July, 2009. ![Gyromagnetic Imaging: Dynamic Optical Contrast Using Gold Nanostars with Magnetic Cores [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Plasmon-resonant nanoparticles with optical scattering in the near-infrared (NIR) are valuable contrast agents for biophotonic imaging and may be detected at the single-particle limit against a dark background, but their contrast is often limited in environments with high noise. Here we consider gyromagnetic imaging as a dynamic mode of optical contrast, using gold nanostars with superparamagnetic cores. The nanostars exhibit polarization-sensitive NIR scattering and can produce a frequency-modulated signal in response to a rotating magnetic field gradient. This periodic ?twinkling? can be converted into Fourier-domain images with a dramatic reduction in background. We demonstrate gyromagnetic imaging of nanostars inside of tumor cells, using broadband excitation: while their time-domain signals are obscured by incoherent scattering, their Fourier-domain signals can be clearly resolved in less than a second. The gyromagnetically active nanostars do not cause a loss in viability, and can even have a mild stimulatory effect on cell growth.
@article{wei_gyromagnetic_2009,
title = {Gyromagnetic {Imaging}: {Dynamic} {Optical} {Contrast} {Using} {Gold} {Nanostars} with {Magnetic} {Cores}},
volume = {131},
issn = {0002-7863},
shorttitle = {Gyromagnetic {Imaging}},
url = {http://dx.doi.org/10.1021/ja901562j},
doi = {10.1021/ja901562j},
abstract = {Plasmon-resonant nanoparticles with optical scattering in the near-infrared (NIR) are valuable contrast agents for biophotonic imaging and may be detected at the single-particle limit against a dark background, but their contrast is often limited in environments with high noise. Here we consider gyromagnetic imaging as a dynamic mode of optical contrast, using gold nanostars with superparamagnetic cores. The nanostars exhibit polarization-sensitive NIR scattering and can produce a frequency-modulated signal in response to a rotating magnetic field gradient. This periodic ?twinkling? can be converted into Fourier-domain images with a dramatic reduction in background. We demonstrate gyromagnetic imaging of nanostars inside of tumor cells, using broadband excitation: while their time-domain signals are obscured by incoherent scattering, their Fourier-domain signals can be clearly resolved in less than a second. The gyromagnetically active nanostars do not cause a loss in viability, and can even have a mild stimulatory effect on cell growth.},
number = {28},
urldate = {2014-11-13TZ},
journal = {Journal of the American Chemical Society},
author = {Wei, Qingshan and Song, Hyon-Min and Leonov, Alexei P. and Hale, Jacob A. and Oh, Dongmyung and Ong, Quy K. and Ritchie, Kenneth and Wei, Alexander},
month = jul,
year = {2009},
pages = {9728--9734}
}
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