Electrophysiological effects of cetirizine, astemizole and D-sotalol in a canine model of long QT syndrome. Weissenburger, J., Noyer, M., Cheymol, G., & Jaillon, P. Clin Exp Allergy, 29 Suppl 3:190--106, July, 1999. bibtex @Article{RSM:Wei99,
author = "J. Weissenburger and M. Noyer and G. Cheymol and P.
Jaillon",
title = "Electrophysiological effects of cetirizine, astemizole
and {D}-sotalol in a canine model of long {QT}
syndrome.",
journal = "Clin Exp Allergy",
year = "1999",
month = jul,
volume = "29 Suppl 3",
pages = "190--106",
robnote = "We compared cetirizine, another compound of that
class, to D-sotalol and to astemizole in a model of
acquired long QT syndrome. Open-chest surgery was
performed in adult beagle dogs anaesthetized with
halothane and thiopental. Bradycardia was produced with
beta-adrenergic blockade and sinus node crush. Four
left ventricular intramyocardial unipolar monophasic
action potentials (MAP) were recorded during atrial
pacing at basic cycle lengths (BCL) 400-1500 msec,
before and during three successive 1-h drug infusions
(0.14, 0.45 and 1.4 mg/kg/h for astemizole and
cetirizine and 1.1, 2.2 and 4.5 mg/kg/h for D-sotalol).
Dose- and bradycardia-dependent prolongations of MAP
duration (MAPD) were produced by D-sotalol (P < 0.001)
and astemizole (P < 0.001) but not by cetirizine. At
BCL 1500 ms, the three infusions of astemizole
prolonged endocardial MAPD from 323 +/- 8 msec (mean
+/- SE) at baseline to 343 +/- 10, 379 +/- 13 and 468
+/- 26 msec, respectively (n = 9). Sotalol prolonged
that MAPD from 339 +/- 6 msec to 377 +/- 7, 444 +/- 15
and 485 +/- 24 msec (n = 7). In contrast, cetirizine
did not prolong MAPD: 341 +/- 8 msec at baseline Vs 330
+/- 8, 324 +/- 9 and 323 +/- 11 msec (n = 9).
Drug-induced increase in transmural dispersion reached
+79 +/- 19 msec after astemizole, +59 +/- 21 msec after
D-sotalol and only +7 +/- 11 msec after cetirizine.
Runs of ventricular tachycardias and torsades de
pointes occurred during dose three of astemizole (5/9
dogs) and D-sotalol (4/7 dogs) but never during
cetirizine. In the present model, astemizole and
D-sotalol but not cetirizine prolonged MAPD and
transmural dispersions of repolarization and produced
torsades de pointes. terfenadine mentioned but not
studied",
bibdate = "Fri Dec 29 13:43:13 2000",
}
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{"_id":"8WMLLsMPCbwRqcfkb","bibbaseid":"weissenburger-noyer-cheymol-jaillon-electrophysiologicaleffectsofcetirizineastemizoleanddsotalolinacaninemodeloflongqtsyndrome-1999","downloads":0,"creationDate":"2016-07-01T21:38:42.857Z","title":"Electrophysiological effects of cetirizine, astemizole and D-sotalol in a canine model of long QT syndrome.","author_short":["Weissenburger, J.","Noyer, M.","Cheymol, G.","Jaillon, P."],"year":1999,"bibtype":"article","biburl":"http://www.sci.utah.edu/~macleod/Bibtex/biglit.bib","bibdata":{"bibtype":"article","type":"article","author":[{"firstnames":["J."],"propositions":[],"lastnames":["Weissenburger"],"suffixes":[]},{"firstnames":["M."],"propositions":[],"lastnames":["Noyer"],"suffixes":[]},{"firstnames":["G."],"propositions":[],"lastnames":["Cheymol"],"suffixes":[]},{"firstnames":["P."],"propositions":[],"lastnames":["Jaillon"],"suffixes":[]}],"title":"Electrophysiological effects of cetirizine, astemizole and D-sotalol in a canine model of long QT syndrome.","journal":"Clin Exp Allergy","year":"1999","month":"July","volume":"29 Suppl 3","pages":"190--106","robnote":"We compared cetirizine, another compound of that class, to D-sotalol and to astemizole in a model of acquired long QT syndrome. Open-chest surgery was performed in adult beagle dogs anaesthetized with halothane and thiopental. Bradycardia was produced with beta-adrenergic blockade and sinus node crush. Four left ventricular intramyocardial unipolar monophasic action potentials (MAP) were recorded during atrial pacing at basic cycle lengths (BCL) 400-1500 msec, before and during three successive 1-h drug infusions (0.14, 0.45 and 1.4 mg/kg/h for astemizole and cetirizine and 1.1, 2.2 and 4.5 mg/kg/h for D-sotalol). Dose- and bradycardia-dependent prolongations of MAP duration (MAPD) were produced by D-sotalol (P < 0.001) and astemizole (P < 0.001) but not by cetirizine. At BCL 1500 ms, the three infusions of astemizole prolonged endocardial MAPD from 323 +/- 8 msec (mean +/- SE) at baseline to 343 +/- 10, 379 +/- 13 and 468 +/- 26 msec, respectively (n = 9). Sotalol prolonged that MAPD from 339 +/- 6 msec to 377 +/- 7, 444 +/- 15 and 485 +/- 24 msec (n = 7). In contrast, cetirizine did not prolong MAPD: 341 +/- 8 msec at baseline Vs 330 +/- 8, 324 +/- 9 and 323 +/- 11 msec (n = 9). Drug-induced increase in transmural dispersion reached +79 +/- 19 msec after astemizole, +59 +/- 21 msec after D-sotalol and only +7 +/- 11 msec after cetirizine. Runs of ventricular tachycardias and torsades de pointes occurred during dose three of astemizole (5/9 dogs) and D-sotalol (4/7 dogs) but never during cetirizine. In the present model, astemizole and D-sotalol but not cetirizine prolonged MAPD and transmural dispersions of repolarization and produced torsades de pointes. terfenadine mentioned but not studied","bibdate":"Fri Dec 29 13:43:13 2000","bibtex":"@Article{RSM:Wei99,\n author = \"J. Weissenburger and M. Noyer and G. Cheymol and P.\n Jaillon\",\n title = \"Electrophysiological effects of cetirizine, astemizole\n and {D}-sotalol in a canine model of long {QT}\n syndrome.\",\n journal = \"Clin Exp Allergy\",\n year = \"1999\",\n month = jul,\n volume = \"29 Suppl 3\",\n pages = \"190--106\",\n robnote = \"We compared cetirizine, another compound of that\n class, to D-sotalol and to astemizole in a model of\n acquired long QT syndrome. Open-chest surgery was\n performed in adult beagle dogs anaesthetized with\n halothane and thiopental. Bradycardia was produced with\n beta-adrenergic blockade and sinus node crush. Four\n left ventricular intramyocardial unipolar monophasic\n action potentials (MAP) were recorded during atrial\n pacing at basic cycle lengths (BCL) 400-1500 msec,\n before and during three successive 1-h drug infusions\n (0.14, 0.45 and 1.4 mg/kg/h for astemizole and\n cetirizine and 1.1, 2.2 and 4.5 mg/kg/h for D-sotalol).\n Dose- and bradycardia-dependent prolongations of MAP\n duration (MAPD) were produced by D-sotalol (P < 0.001)\n and astemizole (P < 0.001) but not by cetirizine. At\n BCL 1500 ms, the three infusions of astemizole\n prolonged endocardial MAPD from 323 +/- 8 msec (mean\n +/- SE) at baseline to 343 +/- 10, 379 +/- 13 and 468\n +/- 26 msec, respectively (n = 9). Sotalol prolonged\n that MAPD from 339 +/- 6 msec to 377 +/- 7, 444 +/- 15\n and 485 +/- 24 msec (n = 7). In contrast, cetirizine\n did not prolong MAPD: 341 +/- 8 msec at baseline Vs 330\n +/- 8, 324 +/- 9 and 323 +/- 11 msec (n = 9).\n Drug-induced increase in transmural dispersion reached\n +79 +/- 19 msec after astemizole, +59 +/- 21 msec after\n D-sotalol and only +7 +/- 11 msec after cetirizine.\n Runs of ventricular tachycardias and torsades de\n pointes occurred during dose three of astemizole (5/9\n dogs) and D-sotalol (4/7 dogs) but never during\n cetirizine. In the present model, astemizole and\n D-sotalol but not cetirizine prolonged MAPD and\n transmural dispersions of repolarization and produced\n torsades de pointes. terfenadine mentioned but not\n studied\",\n bibdate = \"Fri Dec 29 13:43:13 2000\",\n}\n\n","author_short":["Weissenburger, J.","Noyer, M.","Cheymol, G.","Jaillon, P."],"key":"RSM:Wei99","id":"RSM:Wei99","bibbaseid":"weissenburger-noyer-cheymol-jaillon-electrophysiologicaleffectsofcetirizineastemizoleanddsotalolinacaninemodeloflongqtsyndrome-1999","role":"author","urls":{},"downloads":0,"html":""},"search_terms":["electrophysiological","effects","cetirizine","astemizole","sotalol","canine","model","long","syndrome","weissenburger","noyer","cheymol","jaillon"],"keywords":[],"authorIDs":[],"dataSources":["5HG3Kp8zRwDd7FotB"]}