Neurogenic radial glial cells in reptile, rodent and human: from mitosis to migration. Weissman, T., Noctor, S. C, Clinton, B. K, Honig, L. S, & Kriegstein, A. R Cereb Cortex, 13(6):550–559, United States, June, 2003.
abstract   bibtex   
Radial glial cells play at least two crucial roles in cortical development: neuronal production in the ventricular zone (VZ) and the subsequent guidance of neuronal migration. There is evidence that radial glia-like cells are present not only during development but in the adult mammalian brain as well. In addition, radial glial cells appear to be neurogenic in the central nervous system of a number of vertebrate species. We demonstrate here that most dividing progenitor cells in the embryonic human VZ express radial glial proteins. Furthermore, we provide evidence that radial glial cells maintain a vimentin-positive radial fiber throughout each stage of cell division. Asymmetric inheritance of this fiber may be an important factor in determining how neuronal progeny will migrate into the developing cortical plate. Although radial glial cells have traditionally been characterized by their role in guiding migration, their role as neuronal progenitors may represent their defining characteristic throughout the vertebrate CNS.
@ARTICLE{Weissman2003-hg,
  title    = "Neurogenic radial glial cells in reptile, rodent and human: from
              mitosis to migration",
  author   = "Weissman, Tamily and Noctor, Stephen C and Clinton, Brian K and
              Honig, Lawrence S and Kriegstein, Arnold R",
  abstract = "Radial glial cells play at least two crucial roles in cortical
              development: neuronal production in the ventricular zone (VZ) and
              the subsequent guidance of neuronal migration. There is evidence
              that radial glia-like cells are present not only during
              development but in the adult mammalian brain as well. In
              addition, radial glial cells appear to be neurogenic in the
              central nervous system of a number of vertebrate species. We
              demonstrate here that most dividing progenitor cells in the
              embryonic human VZ express radial glial proteins. Furthermore, we
              provide evidence that radial glial cells maintain a
              vimentin-positive radial fiber throughout each stage of cell
              division. Asymmetric inheritance of this fiber may be an
              important factor in determining how neuronal progeny will migrate
              into the developing cortical plate. Although radial glial cells
              have traditionally been characterized by their role in guiding
              migration, their role as neuronal progenitors may represent their
              defining characteristic throughout the vertebrate CNS.",
  journal  = "Cereb Cortex",
  volume   =  13,
  number   =  6,
  pages    = "550--559",
  month    =  jun,
  year     =  2003,
  address  = "United States",
  language = "en"
}

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