@ARTICLE{Weissman2004-ov,
  title    = "Calcium waves propagate through radial glial cells and modulate
              proliferation in the developing neocortex",
  author   = "Weissman, Tamily A and Riquelme, Patricio A and Ivic, Lidija and
              Flint, Alexander C and Kriegstein, Arnold R",
  abstract = "The majority of neurons in the adult neocortex are produced
              embryonically during a brief but intense period of neuronal
              proliferation. The radial glial cell, a transient embryonic cell
              type known for its crucial role in neuronal migration, has
              recently been shown to function as a neuronal progenitor cell and
              appears to produce most cortical pyramidal neurons. Radial glial
              cell modulation could thus affect neuron production, neuronal
              migration, and overall cortical architecture; however, signaling
              mechanisms among radial glia have not been studied directly. We
              demonstrate here that calcium waves propagate through radial
              glial cells in the proliferative cortical ventricular zone (VZ).
              Radial glial calcium waves occur spontaneously and require
              connexin hemichannels, P2Y1 ATP receptors, and intracellular
              IP3-mediated calcium release. Furthermore, we show that wave
              disruption decreases VZ proliferation during the peak of
              embryonic neurogenesis. Taken together, these results demonstrate
              a radial glial signaling mechanism that may regulate cortical
              neuronal production.",
  journal  = "Neuron",
  volume   =  43,
  number   =  5,
  pages    = "647--661",
  month    =  sep,
  year     =  2004,
  address  = "United States",
  language = "en"
}

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