@article{
 title = {Potent and selective α1Aadrenoceptor partial agonists-Novel imidazole frameworks},
 type = {article},
 year = {2009},
 keywords = {Partial agonist,α1AAdrenergic receptor},
 pages = {3118-3121},
 volume = {19},
 websites = {http://ac.els-cdn.com/S0960894X09004867/1-s2.0-S0960894X09004867-main.pdf?_tid=7573847fd1f20ad30107dbf97af3b63d&acdnat=1345645678_e85a25ffff5518bbf16209a42114f2ac},
 publisher = {Elsevier B.V.},
 id = {c1632b4e-b510-3e68-adce-aa840632cf00},
 created = {2015-10-01T17:18:09.000Z},
 file_attached = {true},
 profile_id = {64f7fb50-d000-335d-a02d-06c5f340a97a},
 last_modified = {2018-09-03T10:20:46.233Z},
 read = {false},
 starred = {false},
 authored = {true},
 confirmed = {true},
 hidden = {false},
 citation_key = {Whitlock2009},
 source_type = {Journal Article},
 notes = {CAPLUS AN 2009:603827(Journal)},
 private_publication = {false},
 abstract = {Novel imidazole frameworks have been identified as potent partial agonists of the α1Aadrenergic receptor, with good selectivity over the α1B, α1Dand α2Areceptor sub-types. Nitrile 28 possessed attractive CNS drug-like properties with good membrane permeability and no P-pg mediated efflux. 28 also possessed excellent solubility, metabolic stability and wide ligand selectivity. © 2009 Elsevier Ltd. All rights reserved.},
 bibtype = {article},
 author = {Whitlock, Gavin A. and Brennan, Paul E. and Roberts, Lee R. and Stobie, Alan},
 doi = {10.1016/j.bmcl.2009.03.162},
 journal = {Bioorganic and Medicinal Chemistry Letters},
 number = {11}
}

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