@ARTICLE{Wilson1991-wi,
  title    = "Turtle cortical neurons survive glutamate exposures that are
              lethal to mammalian neurons",
  author   = "Wilson, A M and Kriegstein, A R",
  abstract = "Glutamate is an excitatory neurotransmitter in turtle and
              mammalian cortex. In high concentrations it is toxic to mammalian
              neurons and is an important mediator in the pathway that leads to
              neuronal death from anoxia. Turtle neurons are remarkably
              resistant to anoxic injury and we sought to determine whether
              part of this resistance could be attributed to the sensitivity of
              turtle neurons to glutamate toxicity. Embryonic turtle cortical
              neurons were grown for 25 days in dissociated cell culture using
              a modification of a method developed for murine cortical cell
              culture. Turtle neurons in dissociated culture were found to
              express glutamate receptors which include both
              N-methyl-D-aspartate (NMDA) and non-NMDA receptor types.
              Remarkably, these neurons survive 5 minute exposures to glutamate
              in concentrations up to 3 mM, doses 30 times the LD50 and 6 times
              the LD100 for mouse cortical neurons. Elucidating the mechanism
              for this resistance may suggest new strategies for brain
              protection.",
  journal  = "Brain Res",
  volume   =  540,
  number   = "1-2",
  pages    = "297--301",
  month    =  feb,
  year     =  1991,
  address  = "Netherlands",
  language = "en"
}

{"_id":"ZFysZC4u9nPKHf8fe","bibbaseid":"wilson-kriegstein-turtlecorticalneuronssurviveglutamateexposuresthatarelethaltomammalianneurons-1991","author_short":["Wilson, A M","Kriegstein, A R"],"bibdata":{"bibtype":"article","type":"article","title":"Turtle cortical neurons survive glutamate exposures that are lethal to mammalian neurons","author":[{"propositions":[],"lastnames":["Wilson"],"firstnames":["A","M"],"suffixes":[]},{"propositions":[],"lastnames":["Kriegstein"],"firstnames":["A","R"],"suffixes":[]}],"abstract":"Glutamate is an excitatory neurotransmitter in turtle and mammalian cortex. In high concentrations it is toxic to mammalian neurons and is an important mediator in the pathway that leads to neuronal death from anoxia. Turtle neurons are remarkably resistant to anoxic injury and we sought to determine whether part of this resistance could be attributed to the sensitivity of turtle neurons to glutamate toxicity. Embryonic turtle cortical neurons were grown for 25 days in dissociated cell culture using a modification of a method developed for murine cortical cell culture. Turtle neurons in dissociated culture were found to express glutamate receptors which include both N-methyl-D-aspartate (NMDA) and non-NMDA receptor types. Remarkably, these neurons survive 5 minute exposures to glutamate in concentrations up to 3 mM, doses 30 times the LD50 and 6 times the LD100 for mouse cortical neurons. Elucidating the mechanism for this resistance may suggest new strategies for brain protection.","journal":"Brain Res","volume":"540","number":"1-2","pages":"297–301","month":"February","year":"1991","address":"Netherlands","language":"en","bibtex":"@ARTICLE{Wilson1991-wi,\n title = \"Turtle cortical neurons survive glutamate exposures that are\n lethal to mammalian neurons\",\n author = \"Wilson, A M and Kriegstein, A R\",\n abstract = \"Glutamate is an excitatory neurotransmitter in turtle and\n mammalian cortex. In high concentrations it is toxic to mammalian\n neurons and is an important mediator in the pathway that leads to\n neuronal death from anoxia. Turtle neurons are remarkably\n resistant to anoxic injury and we sought to determine whether\n part of this resistance could be attributed to the sensitivity of\n turtle neurons to glutamate toxicity. Embryonic turtle cortical\n neurons were grown for 25 days in dissociated cell culture using\n a modification of a method developed for murine cortical cell\n culture. Turtle neurons in dissociated culture were found to\n express glutamate receptors which include both\n N-methyl-D-aspartate (NMDA) and non-NMDA receptor types.\n Remarkably, these neurons survive 5 minute exposures to glutamate\n in concentrations up to 3 mM, doses 30 times the LD50 and 6 times\n the LD100 for mouse cortical neurons. Elucidating the mechanism\n for this resistance may suggest new strategies for brain\n protection.\",\n journal = \"Brain Res\",\n volume = 540,\n number = \"1-2\",\n pages = \"297--301\",\n month = feb,\n year = 1991,\n address = \"Netherlands\",\n language = \"en\"\n}\n\n","author_short":["Wilson, A M","Kriegstein, A R"],"key":"Wilson1991-wi","id":"Wilson1991-wi","bibbaseid":"wilson-kriegstein-turtlecorticalneuronssurviveglutamateexposuresthatarelethaltomammalianneurons-1991","role":"author","urls":{},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/f/EJMp3HRuxirjxpcXh/references.bib","dataSources":["sAFYeB74DpbdXM9NN","4zx9n2tbeLTix3Wxr","k3cdWrThyTh5o59Rm","hq9pebjzmsTuyxGGx","h8Atv2SAy4PmShg5j"],"keywords":[],"search_terms":["turtle","cortical","neurons","survive","glutamate","exposures","lethal","mammalian","neurons","wilson","kriegstein"],"title":"Turtle cortical neurons survive glutamate exposures that are lethal to mammalian neurons","year":1991}