@article{RN234,
   author = {Wong, S. M. and Backes, W. H. and Drenthen, G. S. and Zhang, C. E. and Voorter, P. H. M. and Staals, J. and van Oostenbrugge, R. J. and Jansen, J. F. A.},
   title = {Spectral Diffusion Analysis of Intravoxel Incoherent Motion MRI in Cerebral Small Vessel Disease},
   journal = {J Magn Reson Imaging},
   volume = {51},
   number = {4},
   pages = {1170-1180},
   note = {Wong, Sau May
Backes, Walter H
Drenthen, Gerhard S
Zhang, C Eleana
Voorter, Paulien H M
Staals, Julie
van Oostenbrugge, Robert J
Jansen, Jacobus F A
eng
NO 666881/European Unions Horizon 2020 research and innovation programme
SVDs@target
2013(1)-195/Hersenstichting
017.009.048/Netherlands Organization for Scientific Research
Stichting de Weijerhorst
2019/09/06 06:00
J Magn Reson Imaging. 2020 Apr;51(4):1170-1180. doi: 10.1002/jmri.26920. Epub 2019 Sep 4.},
   abstract = {BACKGROUND: Cerebral intravoxel incoherent motion (IVIM) imaging assumes two components. However, more compartments are likely present in pathologic tissue. We hypothesized that spectral analysis using a nonnegative least-squares (NNLS) approach can detect an additional, intermediate diffusion component, distinct from the parenchymal and microvascular components, in lesion-prone regions. PURPOSE: To investigate the presence of this intermediate diffusion component and its relation with cerebral small vessel disease (cSVD)-related lesions. STUDY TYPE: Prospective cross-sectional study. POPULATION: Patients with cSVD (n = 69, median age 69.8) and controls (n = 39, median age 68.9). FIELD STRENGTH/SEQUENCE: Whole-brain inversion recovery IVIM acquisition at 3.0T. ASSESSMENT: Enlarged perivascular spaces (PVS) were rated by three raters. White matter hyperintensities (WMH) were identified on a fluid attenuated inversion recovery (FLAIR) image using a semiautomated algorithm. STATISTICAL TESTS: Relations between IVIM measures and cSVD-related lesions were studied using the Spearman's rank order correlation. RESULTS: NNLS yielded diffusion spectra from which the intermediate volume fraction fint was apparent between parenchymal diffusion and microvasular pseudodiffusion. WMH volume and the extent of MRI-visible enlarged PVS in the basal ganglia (BG) and centrum semiovale (CSO) were correlated with fint in the WMHs, BG, and CSO, respectively. fint was 4.2 +/- 1.7%, 7.0 +/- 4.1% and 13.6 +/- 7.7% in BG and 3.9 +/- 1.3%, 4.4 +/- 1.4% and 4.5 +/- 1.2% in CSO for the groups with low, moderate, and high number of enlarged PVS, respectively, and increased with the extent of enlarged PVS (BG: r = 0.49, P < 0.01; CSO: r = 0.23, P = 0.02). fint in the WMHs was 27.1 +/- 13.1%, and increased with the WMH volume (r = 0.57, P < 0.01). DATA CONCLUSION: We revealed the presence of an intermediate diffusion component in lesion-prone regions of cSVD and demonstrated its relation with enlarged PVS and WMHs. In tissue with these lesions, tissue degeneration or perivascular edema can lead to more freely diffusing interstitial fluid contributing to fint . LEVEL OF EVIDENCE: 2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2020;51:1170-1180.},
   keywords = {Mri
cerebral small vessel disease
diffusion magnetic resonance imaging
glymphatic system},
   ISSN = {1522-2586 (Electronic)
1053-1807 (Linking)},
   DOI = {10.1002/jmri.26920},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/31486211
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078988/pdf/JMRI-51-1170.pdf},
   year = {2020},
   type = {Journal Article}
}

{"_id":"27QqefAXZ7usuKdwH","bibbaseid":"wong-backes-drenthen-zhang-voorter-staals-vanoostenbrugge-jansen-spectraldiffusionanalysisofintravoxelincoherentmotionmriincerebralsmallvesseldisease-2020","authorIDs":["4Tm3oPxNFFsEkR6pe","7YnznfJEbNoLRQfCK","9uYiZAT4SGYEdwuhG","CHX5tw5dNmS7tFMt9","DB2BA5PJJ7o8mgnGD","DoNKbgB55xkR6SehT","FEbMpouv9cRyJBZv3","GtL5d4iFpEuoJacN7","HLzbcixmNhduwmTFt","Jeci2sNzJiMSDeJvc","NAFTFJTb9GJgC2h6i","QqoDaykDZWJd9YuAu","SMWTZ3jeKpHtbuWdG","TEAWLnKpXtQE8hs6C","X6hbvpsSihwFQpXSk","dGQk363jLcfCvKxGW","dR2ye6bifAsonnNMz","eJ9fizm2KNxBgiNfF","hGdeHv63Gb3m6CybW","hShritfXo7Lzr2RkJ","jDvmx9aE5aohaf7P7","mgkaKGSdieQZcsntZ","rQrciQZhPyL9ovwM8","txfqjmhcnxmvnAv2m","zTR82AHQxLXLWt4wi"],"author_short":["Wong, S. M.","Backes, W. H.","Drenthen, G. S.","Zhang, C. E.","Voorter, P. H. M.","Staals, J.","van Oostenbrugge, R. J.","Jansen, J. F. A."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Wong"],"firstnames":["S.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Drenthen"],"firstnames":["G.","S."],"suffixes":[]},{"propositions":[],"lastnames":["Zhang"],"firstnames":["C.","E."],"suffixes":[]},{"propositions":[],"lastnames":["Voorter"],"firstnames":["P.","H.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Staals"],"firstnames":["J."],"suffixes":[]},{"propositions":["van"],"lastnames":["Oostenbrugge"],"firstnames":["R.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F.","A."],"suffixes":[]}],"title":"Spectral Diffusion Analysis of Intravoxel Incoherent Motion MRI in Cerebral Small Vessel Disease","journal":"J Magn Reson Imaging","volume":"51","number":"4","pages":"1170-1180","note":"Wong, Sau May Backes, Walter H Drenthen, Gerhard S Zhang, C Eleana Voorter, Paulien H M Staals, Julie van Oostenbrugge, Robert J Jansen, Jacobus F A eng NO 666881/European Unions Horizon 2020 research and innovation programme SVDs@target 2013(1)-195/Hersenstichting 017.009.048/Netherlands Organization for Scientific Research Stichting de Weijerhorst 2019/09/06 06:00 J Magn Reson Imaging. 2020 Apr;51(4):1170-1180. doi: 10.1002/jmri.26920. Epub 2019 Sep 4.","abstract":"BACKGROUND: Cerebral intravoxel incoherent motion (IVIM) imaging assumes two components. However, more compartments are likely present in pathologic tissue. We hypothesized that spectral analysis using a nonnegative least-squares (NNLS) approach can detect an additional, intermediate diffusion component, distinct from the parenchymal and microvascular components, in lesion-prone regions. PURPOSE: To investigate the presence of this intermediate diffusion component and its relation with cerebral small vessel disease (cSVD)-related lesions. STUDY TYPE: Prospective cross-sectional study. POPULATION: Patients with cSVD (n = 69, median age 69.8) and controls (n = 39, median age 68.9). FIELD STRENGTH/SEQUENCE: Whole-brain inversion recovery IVIM acquisition at 3.0T. ASSESSMENT: Enlarged perivascular spaces (PVS) were rated by three raters. White matter hyperintensities (WMH) were identified on a fluid attenuated inversion recovery (FLAIR) image using a semiautomated algorithm. STATISTICAL TESTS: Relations between IVIM measures and cSVD-related lesions were studied using the Spearman's rank order correlation. RESULTS: NNLS yielded diffusion spectra from which the intermediate volume fraction fint was apparent between parenchymal diffusion and microvasular pseudodiffusion. WMH volume and the extent of MRI-visible enlarged PVS in the basal ganglia (BG) and centrum semiovale (CSO) were correlated with fint in the WMHs, BG, and CSO, respectively. fint was 4.2 +/- 1.7%, 7.0 +/- 4.1% and 13.6 +/- 7.7% in BG and 3.9 +/- 1.3%, 4.4 +/- 1.4% and 4.5 +/- 1.2% in CSO for the groups with low, moderate, and high number of enlarged PVS, respectively, and increased with the extent of enlarged PVS (BG: r = 0.49, P < 0.01; CSO: r = 0.23, P = 0.02). fint in the WMHs was 27.1 +/- 13.1%, and increased with the WMH volume (r = 0.57, P < 0.01). DATA CONCLUSION: We revealed the presence of an intermediate diffusion component in lesion-prone regions of cSVD and demonstrated its relation with enlarged PVS and WMHs. In tissue with these lesions, tissue degeneration or perivascular edema can lead to more freely diffusing interstitial fluid contributing to fint . LEVEL OF EVIDENCE: 2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2020;51:1170-1180.","keywords":"Mri cerebral small vessel disease diffusion magnetic resonance imaging glymphatic system","issn":"1522-2586 (Electronic) 1053-1807 (Linking)","doi":"10.1002/jmri.26920","url":"http://www.ncbi.nlm.nih.gov/pubmed/31486211 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078988/pdf/JMRI-51-1170.pdf","year":"2020","bibtex":"@article{RN234,\n author = {Wong, S. M. and Backes, W. H. and Drenthen, G. S. and Zhang, C. E. and Voorter, P. H. M. and Staals, J. and van Oostenbrugge, R. J. and Jansen, J. F. A.},\n title = {Spectral Diffusion Analysis of Intravoxel Incoherent Motion MRI in Cerebral Small Vessel Disease},\n journal = {J Magn Reson Imaging},\n volume = {51},\n number = {4},\n pages = {1170-1180},\n note = {Wong, Sau May\nBackes, Walter H\nDrenthen, Gerhard S\nZhang, C Eleana\nVoorter, Paulien H M\nStaals, Julie\nvan Oostenbrugge, Robert J\nJansen, Jacobus F A\neng\nNO 666881/European Unions Horizon 2020 research and innovation programme\nSVDs@target\n2013(1)-195/Hersenstichting\n017.009.048/Netherlands Organization for Scientific Research\nStichting de Weijerhorst\n2019/09/06 06:00\nJ Magn Reson Imaging. 2020 Apr;51(4):1170-1180. doi: 10.1002/jmri.26920. Epub 2019 Sep 4.},\n abstract = {BACKGROUND: Cerebral intravoxel incoherent motion (IVIM) imaging assumes two components. However, more compartments are likely present in pathologic tissue. We hypothesized that spectral analysis using a nonnegative least-squares (NNLS) approach can detect an additional, intermediate diffusion component, distinct from the parenchymal and microvascular components, in lesion-prone regions. PURPOSE: To investigate the presence of this intermediate diffusion component and its relation with cerebral small vessel disease (cSVD)-related lesions. STUDY TYPE: Prospective cross-sectional study. POPULATION: Patients with cSVD (n = 69, median age 69.8) and controls (n = 39, median age 68.9). FIELD STRENGTH/SEQUENCE: Whole-brain inversion recovery IVIM acquisition at 3.0T. ASSESSMENT: Enlarged perivascular spaces (PVS) were rated by three raters. White matter hyperintensities (WMH) were identified on a fluid attenuated inversion recovery (FLAIR) image using a semiautomated algorithm. STATISTICAL TESTS: Relations between IVIM measures and cSVD-related lesions were studied using the Spearman's rank order correlation. RESULTS: NNLS yielded diffusion spectra from which the intermediate volume fraction fint was apparent between parenchymal diffusion and microvasular pseudodiffusion. WMH volume and the extent of MRI-visible enlarged PVS in the basal ganglia (BG) and centrum semiovale (CSO) were correlated with fint in the WMHs, BG, and CSO, respectively. fint was 4.2 +/- 1.7%, 7.0 +/- 4.1% and 13.6 +/- 7.7% in BG and 3.9 +/- 1.3%, 4.4 +/- 1.4% and 4.5 +/- 1.2% in CSO for the groups with low, moderate, and high number of enlarged PVS, respectively, and increased with the extent of enlarged PVS (BG: r = 0.49, P < 0.01; CSO: r = 0.23, P = 0.02). fint in the WMHs was 27.1 +/- 13.1%, and increased with the WMH volume (r = 0.57, P < 0.01). DATA CONCLUSION: We revealed the presence of an intermediate diffusion component in lesion-prone regions of cSVD and demonstrated its relation with enlarged PVS and WMHs. In tissue with these lesions, tissue degeneration or perivascular edema can lead to more freely diffusing interstitial fluid contributing to fint . LEVEL OF EVIDENCE: 2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2020;51:1170-1180.},\n keywords = {Mri\ncerebral small vessel disease\ndiffusion magnetic resonance imaging\nglymphatic system},\n ISSN = {1522-2586 (Electronic)\n1053-1807 (Linking)},\n DOI = {10.1002/jmri.26920},\n url = {http://www.ncbi.nlm.nih.gov/pubmed/31486211\nhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078988/pdf/JMRI-51-1170.pdf},\n year = {2020},\n type = {Journal Article}\n}\n\n","author_short":["Wong, S. M.","Backes, W. H.","Drenthen, G. S.","Zhang, C. E.","Voorter, P. H. M.","Staals, J.","van Oostenbrugge, R. J.","Jansen, J. F. A."],"key":"RN234","id":"RN234","bibbaseid":"wong-backes-drenthen-zhang-voorter-staals-vanoostenbrugge-jansen-spectraldiffusionanalysisofintravoxelincoherentmotionmriincerebralsmallvesseldisease-2020","role":"author","urls":{"Paper":"http://www.ncbi.nlm.nih.gov/pubmed/31486211 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078988/pdf/JMRI-51-1170.pdf"},"keyword":["Mri cerebral small vessel disease diffusion magnetic resonance imaging glymphatic system"],"metadata":{"authorlinks":{"jansen, j":"https://www.jansenjfa.com/publications/","drenthen, g":"http://www.geralddrenthen.nl/research/"}},"downloads":0,"html":""},"bibtype":"article","biburl":"https://raw.githubusercontent.com/jansenjfa1/bibbase.github.io/master/jansenjfa.bib","creationDate":"2020-04-26T18:07:10.368Z","downloads":0,"keywords":["mri cerebral small vessel disease diffusion magnetic resonance imaging glymphatic system"],"search_terms":["spectral","diffusion","analysis","intravoxel","incoherent","motion","mri","cerebral","small","vessel","disease","wong","backes","drenthen","zhang","voorter","staals","van oostenbrugge","jansen"],"title":"Spectral Diffusion Analysis of Intravoxel Incoherent Motion MRI in Cerebral Small Vessel Disease","year":2020,"dataSources":["NcYBKGxxHQiyceke2","TCkfRWJAZvbLAZi29","ya2CyA73rpZseyrZ8","2252seNhipfTmjEBQ"]}