On the Reproducibility of Inversion Recovery Intravoxel Incoherent Motion Imaging in Cerebrovascular Disease. Wong, S. M., Backes, W. H., Zhang, C. E., Staals, J., van Oostenbrugge, R. J., Jeukens, C., & Jansen, J. F. A. AJNR Am J Neuroradiol, 39(2):226-231, 2018. Wong, S M Backes, W H Zhang, C E Staals, J van Oostenbrugge, R J Jeukens, C R L P N Jansen, J F A eng Research Support, Non-U.S. Gov't 2017/12/09 06:00 AJNR Am J Neuroradiol. 2018 Feb;39(2):226-231. doi: 10.3174/ajnr.A5474. Epub 2017 Dec 7.
Paper doi abstract bibtex BACKGROUND AND PURPOSE: Intravoxel incoherent motion imaging can measure both microvascular and parenchymal abnormalities simultaneously. The contamination of CSF signal can be suppressed using inversion recovery preparation. The clinical feasibility of inversion recovery-intravoxel incoherent motion imaging was investigated in patients with cerebrovascular disease by studying its reproducibility. MATERIALS AND METHODS: Sixteen patients with cerebrovascular disease (66 +/- 8 years of age) underwent inversion recovery-intravoxel incoherent motion imaging twice. The reproducibility of the perfusion volume fraction and parenchymal diffusivity was calculated with the coefficient of variation, intraclass correlation coefficient, and the repeatability coefficient. ROIs included the normal-appearing white matter, cortex, deep gray matter, white matter hyperintensities, and vascular lesions. RESULTS: Values for the perfusion volume fraction ranged from 2.42 to 3.97 x10(-2) and for parenchymal diffusivity from 7.20 to 9.11 x 10(-4) mm(2)/s, with higher values found in the white matter hyperintensities and vascular lesions. Coefficients of variation were <3.70% in normal-appearing tissue and <9.15% for lesions. Intraclass correlation coefficients were good to excellent, showing values ranging from 0.82 to 0.99 in all ROIs, except the deep gray matter and cortex, with intraclass correlation coefficients of 0.66 and 0.54, respectively. The repeatability coefficients ranged from 0.15 to 0.96 x 10(-2) and 0.10 to 0.37 x 10(-4) mm(2)/s for perfusion volume fraction and parenchymal diffusivity, respectively. CONCLUSIONS: Good reproducibility of inversion recovery-intravoxel incoherent motion imaging was observed with low coefficients of variation and high intraclass correlation coefficients in normal-appearing tissue and lesion areas in cerebrovascular disease. Good reproducibility of inversion recovery-intravoxel incoherent motion imaging in cerebrovascular disease is feasible in monitoring disease progression or treatment responses in the clinic.
@article{RN218,
author = {Wong, S. M. and Backes, W. H. and Zhang, C. E. and Staals, J. and van Oostenbrugge, R. J. and Jeukens, Crlpn and Jansen, J. F. A.},
title = {On the Reproducibility of Inversion Recovery Intravoxel Incoherent Motion Imaging in Cerebrovascular Disease},
journal = {AJNR Am J Neuroradiol},
volume = {39},
number = {2},
pages = {226-231},
note = {Wong, S M
Backes, W H
Zhang, C E
Staals, J
van Oostenbrugge, R J
Jeukens, C R L P N
Jansen, J F A
eng
Research Support, Non-U.S. Gov't
2017/12/09 06:00
AJNR Am J Neuroradiol. 2018 Feb;39(2):226-231. doi: 10.3174/ajnr.A5474. Epub 2017 Dec 7.},
abstract = {BACKGROUND AND PURPOSE: Intravoxel incoherent motion imaging can measure both microvascular and parenchymal abnormalities simultaneously. The contamination of CSF signal can be suppressed using inversion recovery preparation. The clinical feasibility of inversion recovery-intravoxel incoherent motion imaging was investigated in patients with cerebrovascular disease by studying its reproducibility. MATERIALS AND METHODS: Sixteen patients with cerebrovascular disease (66 +/- 8 years of age) underwent inversion recovery-intravoxel incoherent motion imaging twice. The reproducibility of the perfusion volume fraction and parenchymal diffusivity was calculated with the coefficient of variation, intraclass correlation coefficient, and the repeatability coefficient. ROIs included the normal-appearing white matter, cortex, deep gray matter, white matter hyperintensities, and vascular lesions. RESULTS: Values for the perfusion volume fraction ranged from 2.42 to 3.97 x10(-2) and for parenchymal diffusivity from 7.20 to 9.11 x 10(-4) mm(2)/s, with higher values found in the white matter hyperintensities and vascular lesions. Coefficients of variation were <3.70% in normal-appearing tissue and <9.15% for lesions. Intraclass correlation coefficients were good to excellent, showing values ranging from 0.82 to 0.99 in all ROIs, except the deep gray matter and cortex, with intraclass correlation coefficients of 0.66 and 0.54, respectively. The repeatability coefficients ranged from 0.15 to 0.96 x 10(-2) and 0.10 to 0.37 x 10(-4) mm(2)/s for perfusion volume fraction and parenchymal diffusivity, respectively. CONCLUSIONS: Good reproducibility of inversion recovery-intravoxel incoherent motion imaging was observed with low coefficients of variation and high intraclass correlation coefficients in normal-appearing tissue and lesion areas in cerebrovascular disease. Good reproducibility of inversion recovery-intravoxel incoherent motion imaging in cerebrovascular disease is feasible in monitoring disease progression or treatment responses in the clinic.},
keywords = {Aged
Brain/*diagnostic imaging
Cerebrovascular Disorders/*diagnostic imaging
Diffusion Magnetic Resonance Imaging/*methods
Female
Gray Matter/diagnostic imaging
Humans
Male
Middle Aged
Motion
Perfusion
Reproducibility of Results
White Matter/diagnostic imaging},
ISSN = {1936-959X (Electronic)
0195-6108 (Linking)},
DOI = {10.3174/ajnr.A5474},
url = {http://www.ncbi.nlm.nih.gov/pubmed/29217741
http://www.ajnr.org/content/ajnr/39/2/226.full.pdf},
year = {2018},
type = {Journal Article}
}
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A."],"year":2018,"bibtype":"article","biburl":"https://raw.githubusercontent.com/jansenjfa1/bibbase.github.io/master/jansenjfa.bib","bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Wong"],"firstnames":["S.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Zhang"],"firstnames":["C.","E."],"suffixes":[]},{"propositions":[],"lastnames":["Staals"],"firstnames":["J."],"suffixes":[]},{"propositions":["van"],"lastnames":["Oostenbrugge"],"firstnames":["R.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Jeukens"],"firstnames":["Crlpn"],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F.","A."],"suffixes":[]}],"title":"On the Reproducibility of Inversion Recovery Intravoxel Incoherent Motion Imaging in Cerebrovascular Disease","journal":"AJNR Am J Neuroradiol","volume":"39","number":"2","pages":"226-231","note":"Wong, S M Backes, W H Zhang, C E Staals, J van Oostenbrugge, R J Jeukens, C R L P N Jansen, J F A eng Research Support, Non-U.S. Gov't 2017/12/09 06:00 AJNR Am J Neuroradiol. 2018 Feb;39(2):226-231. doi: 10.3174/ajnr.A5474. Epub 2017 Dec 7.","abstract":"BACKGROUND AND PURPOSE: Intravoxel incoherent motion imaging can measure both microvascular and parenchymal abnormalities simultaneously. The contamination of CSF signal can be suppressed using inversion recovery preparation. The clinical feasibility of inversion recovery-intravoxel incoherent motion imaging was investigated in patients with cerebrovascular disease by studying its reproducibility. MATERIALS AND METHODS: Sixteen patients with cerebrovascular disease (66 +/- 8 years of age) underwent inversion recovery-intravoxel incoherent motion imaging twice. The reproducibility of the perfusion volume fraction and parenchymal diffusivity was calculated with the coefficient of variation, intraclass correlation coefficient, and the repeatability coefficient. ROIs included the normal-appearing white matter, cortex, deep gray matter, white matter hyperintensities, and vascular lesions. RESULTS: Values for the perfusion volume fraction ranged from 2.42 to 3.97 x10(-2) and for parenchymal diffusivity from 7.20 to 9.11 x 10(-4) mm(2)/s, with higher values found in the white matter hyperintensities and vascular lesions. Coefficients of variation were <3.70% in normal-appearing tissue and <9.15% for lesions. Intraclass correlation coefficients were good to excellent, showing values ranging from 0.82 to 0.99 in all ROIs, except the deep gray matter and cortex, with intraclass correlation coefficients of 0.66 and 0.54, respectively. The repeatability coefficients ranged from 0.15 to 0.96 x 10(-2) and 0.10 to 0.37 x 10(-4) mm(2)/s for perfusion volume fraction and parenchymal diffusivity, respectively. CONCLUSIONS: Good reproducibility of inversion recovery-intravoxel incoherent motion imaging was observed with low coefficients of variation and high intraclass correlation coefficients in normal-appearing tissue and lesion areas in cerebrovascular disease. Good reproducibility of inversion recovery-intravoxel incoherent motion imaging in cerebrovascular disease is feasible in monitoring disease progression or treatment responses in the clinic.","keywords":"Aged Brain/*diagnostic imaging Cerebrovascular Disorders/*diagnostic imaging Diffusion Magnetic Resonance Imaging/*methods Female Gray Matter/diagnostic imaging Humans Male Middle Aged Motion Perfusion Reproducibility of Results White Matter/diagnostic imaging","issn":"1936-959X (Electronic) 0195-6108 (Linking)","doi":"10.3174/ajnr.A5474","url":"http://www.ncbi.nlm.nih.gov/pubmed/29217741 http://www.ajnr.org/content/ajnr/39/2/226.full.pdf","year":"2018","bibtex":"@article{RN218,\n author = {Wong, S. M. and Backes, W. H. and Zhang, C. E. and Staals, J. and van Oostenbrugge, R. J. and Jeukens, Crlpn and Jansen, J. F. A.},\n title = {On the Reproducibility of Inversion Recovery Intravoxel Incoherent Motion Imaging in Cerebrovascular Disease},\n journal = {AJNR Am J Neuroradiol},\n volume = {39},\n number = {2},\n pages = {226-231},\n note = {Wong, S M\nBackes, W H\nZhang, C E\nStaals, J\nvan Oostenbrugge, R J\nJeukens, C R L P N\nJansen, J F A\neng\nResearch Support, Non-U.S. Gov't\n2017/12/09 06:00\nAJNR Am J Neuroradiol. 2018 Feb;39(2):226-231. doi: 10.3174/ajnr.A5474. Epub 2017 Dec 7.},\n abstract = {BACKGROUND AND PURPOSE: Intravoxel incoherent motion imaging can measure both microvascular and parenchymal abnormalities simultaneously. The contamination of CSF signal can be suppressed using inversion recovery preparation. The clinical feasibility of inversion recovery-intravoxel incoherent motion imaging was investigated in patients with cerebrovascular disease by studying its reproducibility. MATERIALS AND METHODS: Sixteen patients with cerebrovascular disease (66 +/- 8 years of age) underwent inversion recovery-intravoxel incoherent motion imaging twice. The reproducibility of the perfusion volume fraction and parenchymal diffusivity was calculated with the coefficient of variation, intraclass correlation coefficient, and the repeatability coefficient. ROIs included the normal-appearing white matter, cortex, deep gray matter, white matter hyperintensities, and vascular lesions. RESULTS: Values for the perfusion volume fraction ranged from 2.42 to 3.97 x10(-2) and for parenchymal diffusivity from 7.20 to 9.11 x 10(-4) mm(2)/s, with higher values found in the white matter hyperintensities and vascular lesions. Coefficients of variation were <3.70% in normal-appearing tissue and <9.15% for lesions. Intraclass correlation coefficients were good to excellent, showing values ranging from 0.82 to 0.99 in all ROIs, except the deep gray matter and cortex, with intraclass correlation coefficients of 0.66 and 0.54, respectively. The repeatability coefficients ranged from 0.15 to 0.96 x 10(-2) and 0.10 to 0.37 x 10(-4) mm(2)/s for perfusion volume fraction and parenchymal diffusivity, respectively. CONCLUSIONS: Good reproducibility of inversion recovery-intravoxel incoherent motion imaging was observed with low coefficients of variation and high intraclass correlation coefficients in normal-appearing tissue and lesion areas in cerebrovascular disease. 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