@article{RN226,
   author = {Wong, S. M. and Jansen, J. F. A. and Zhang, C. E. and Hoff, E. I. and Staals, J. and van Oostenbrugge, R. J. and Backes, W. H.},
   title = {Blood-brain barrier impairment and hypoperfusion are linked in cerebral small vessel disease},
   journal = {Neurology},
   volume = {92},
   number = {15},
   pages = {e1669-e1677},
   note = {Wong, Sau May
Jansen, Jacobus F A
Zhang, C Eleana
Hoff, Erik I
Staals, Julie
van Oostenbrugge, Robert J
Backes, Walter H
eng
Research Support, Non-U.S. Gov't
2019/03/15 06:00
Neurology. 2019 Apr 9;92(15):e1669-e1677. doi: 10.1212/WNL.0000000000007263. Epub 2019 Mar 13.},
   abstract = {OBJECTIVE: To investigate the link between blood-brain-barrier (BBB) permeability and cerebral blood flow (CBF) and the relation with white matter hyperintensities (WMH) in cerebral small vessel disease (cSVD). METHODS: Twenty-seven patients with cSVD received dynamic susceptibility contrast and dynamic contrast-enhanced MRI to determine CBF and BBB permeability (expressed as leakage rate and volume), respectively. Structural MRI were segmented into normal-appearing white matter (NAWM) and WMH, for which a perilesional zone was defined. In these regions, we investigated the BBB permeability, CBF, and their relation using Pearson correlation r. RESULTS: We found a decrease in CBF of 2.2 mL/min/100 g (p < 0.01) and an increase in leakage volume of 0.7% (p < 0.01) per mm closer to the WMH in the perilesional zones. Lower CBF values correlated with higher leakage measures in the NAWM and WMH (-0.53 < r < -0.40, p < 0.05). This relation was also observed in the perilesional zones, which became stronger in the proximity of WMH (p = 0.03). CONCLUSION: BBB impairment and hypoperfusion appear in the WMH and NAWM, which increase in the proximity of the WMH, and are linked. Both BBB and CBF are regulated in the neurovascular unit (NVU) and the observed link might be due to the physiologic regulation mechanism of the NVU. This link may suggest an early overall deterioration of this unit.},
   keywords = {Aged
Blood-Brain Barrier/diagnostic imaging/*pathology
Cerebral Small Vessel Diseases/diagnostic imaging/*pathology
Cerebrospinal Fluid Leak/pathology
Cerebrovascular Circulation
Cerebrovascular Disorders/diagnostic imaging/*pathology
Contrast Media
Female
Gadolinium
Humans
Magnetic Resonance Imaging
Male
Middle Aged
White Matter/diagnostic imaging},
   ISSN = {1526-632X (Electronic)
0028-3878 (Linking)},
   DOI = {10.1212/WNL.0000000000007263},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/30867275
https://n.neurology.org/content/92/15/e1669.long},
   year = {2019},
   type = {Journal Article}
}

{"_id":"aC2MNT2feK788QTv8","bibbaseid":"wong-jansen-zhang-hoff-staals-vanoostenbrugge-backes-bloodbrainbarrierimpairmentandhypoperfusionarelinkedincerebralsmallvesseldisease-2019","downloads":0,"creationDate":"2019-03-20T11:40:23.715Z","title":"Blood-brain barrier impairment and hypoperfusion are linked in cerebral small vessel disease","author_short":["Wong, S. M.","Jansen, J. F. A.","Zhang, C. E.","Hoff, E. I.","Staals, J.","van Oostenbrugge, R. J.","Backes, W. H."],"year":2019,"bibtype":"article","biburl":"https://raw.githubusercontent.com/jansenjfa1/bibbase.github.io/master/jansenjfa.bib","bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Wong"],"firstnames":["S.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Zhang"],"firstnames":["C.","E."],"suffixes":[]},{"propositions":[],"lastnames":["Hoff"],"firstnames":["E.","I."],"suffixes":[]},{"propositions":[],"lastnames":["Staals"],"firstnames":["J."],"suffixes":[]},{"propositions":["van"],"lastnames":["Oostenbrugge"],"firstnames":["R.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W.","H."],"suffixes":[]}],"title":"Blood-brain barrier impairment and hypoperfusion are linked in cerebral small vessel disease","journal":"Neurology","volume":"92","number":"15","pages":"e1669-e1677","note":"Wong, Sau May Jansen, Jacobus F A Zhang, C Eleana Hoff, Erik I Staals, Julie van Oostenbrugge, Robert J Backes, Walter H eng Research Support, Non-U.S. Gov't 2019/03/15 06:00 Neurology. 2019 Apr 9;92(15):e1669-e1677. doi: 10.1212/WNL.0000000000007263. Epub 2019 Mar 13.","abstract":"OBJECTIVE: To investigate the link between blood-brain-barrier (BBB) permeability and cerebral blood flow (CBF) and the relation with white matter hyperintensities (WMH) in cerebral small vessel disease (cSVD). METHODS: Twenty-seven patients with cSVD received dynamic susceptibility contrast and dynamic contrast-enhanced MRI to determine CBF and BBB permeability (expressed as leakage rate and volume), respectively. Structural MRI were segmented into normal-appearing white matter (NAWM) and WMH, for which a perilesional zone was defined. In these regions, we investigated the BBB permeability, CBF, and their relation using Pearson correlation r. RESULTS: We found a decrease in CBF of 2.2 mL/min/100 g (p < 0.01) and an increase in leakage volume of 0.7% (p < 0.01) per mm closer to the WMH in the perilesional zones. Lower CBF values correlated with higher leakage measures in the NAWM and WMH (-0.53 < r < -0.40, p < 0.05). This relation was also observed in the perilesional zones, which became stronger in the proximity of WMH (p = 0.03). CONCLUSION: BBB impairment and hypoperfusion appear in the WMH and NAWM, which increase in the proximity of the WMH, and are linked. Both BBB and CBF are regulated in the neurovascular unit (NVU) and the observed link might be due to the physiologic regulation mechanism of the NVU. This link may suggest an early overall deterioration of this unit.","keywords":"Aged Blood-Brain Barrier/diagnostic imaging/*pathology Cerebral Small Vessel Diseases/diagnostic imaging/*pathology Cerebrospinal Fluid Leak/pathology Cerebrovascular Circulation Cerebrovascular Disorders/diagnostic imaging/*pathology Contrast Media Female Gadolinium Humans Magnetic Resonance Imaging Male Middle Aged White Matter/diagnostic imaging","issn":"1526-632X (Electronic) 0028-3878 (Linking)","doi":"10.1212/WNL.0000000000007263","url":"http://www.ncbi.nlm.nih.gov/pubmed/30867275 https://n.neurology.org/content/92/15/e1669.long","year":"2019","bibtex":"@article{RN226,\n author = {Wong, S. M. and Jansen, J. F. A. and Zhang, C. E. and Hoff, E. I. and Staals, J. and van Oostenbrugge, R. J. and Backes, W. H.},\n title = {Blood-brain barrier impairment and hypoperfusion are linked in cerebral small vessel disease},\n journal = {Neurology},\n volume = {92},\n number = {15},\n pages = {e1669-e1677},\n note = {Wong, Sau May\nJansen, Jacobus F A\nZhang, C Eleana\nHoff, Erik I\nStaals, Julie\nvan Oostenbrugge, Robert J\nBackes, Walter H\neng\nResearch Support, Non-U.S. Gov't\n2019/03/15 06:00\nNeurology. 2019 Apr 9;92(15):e1669-e1677. doi: 10.1212/WNL.0000000000007263. Epub 2019 Mar 13.},\n abstract = {OBJECTIVE: To investigate the link between blood-brain-barrier (BBB) permeability and cerebral blood flow (CBF) and the relation with white matter hyperintensities (WMH) in cerebral small vessel disease (cSVD). METHODS: Twenty-seven patients with cSVD received dynamic susceptibility contrast and dynamic contrast-enhanced MRI to determine CBF and BBB permeability (expressed as leakage rate and volume), respectively. Structural MRI were segmented into normal-appearing white matter (NAWM) and WMH, for which a perilesional zone was defined. In these regions, we investigated the BBB permeability, CBF, and their relation using Pearson correlation r. RESULTS: We found a decrease in CBF of 2.2 mL/min/100 g (p < 0.01) and an increase in leakage volume of 0.7% (p < 0.01) per mm closer to the WMH in the perilesional zones. Lower CBF values correlated with higher leakage measures in the NAWM and WMH (-0.53 < r < -0.40, p < 0.05). This relation was also observed in the perilesional zones, which became stronger in the proximity of WMH (p = 0.03). CONCLUSION: BBB impairment and hypoperfusion appear in the WMH and NAWM, which increase in the proximity of the WMH, and are linked. Both BBB and CBF are regulated in the neurovascular unit (NVU) and the observed link might be due to the physiologic regulation mechanism of the NVU. This link may suggest an early overall deterioration of this unit.},\n keywords = {Aged\nBlood-Brain Barrier/diagnostic imaging/*pathology\nCerebral Small Vessel Diseases/diagnostic imaging/*pathology\nCerebrospinal Fluid Leak/pathology\nCerebrovascular Circulation\nCerebrovascular Disorders/diagnostic imaging/*pathology\nContrast Media\nFemale\nGadolinium\nHumans\nMagnetic Resonance Imaging\nMale\nMiddle Aged\nWhite Matter/diagnostic imaging},\n ISSN = {1526-632X (Electronic)\n0028-3878 (Linking)},\n DOI = {10.1212/WNL.0000000000007263},\n url = {http://www.ncbi.nlm.nih.gov/pubmed/30867275\nhttps://n.neurology.org/content/92/15/e1669.long},\n year = {2019},\n type = {Journal Article}\n}\n\n","author_short":["Wong, S. M.","Jansen, J. F. A.","Zhang, C. E.","Hoff, E. I.","Staals, J.","van Oostenbrugge, R. J.","Backes, W. H."],"key":"RN226","id":"RN226","bibbaseid":"wong-jansen-zhang-hoff-staals-vanoostenbrugge-backes-bloodbrainbarrierimpairmentandhypoperfusionarelinkedincerebralsmallvesseldisease-2019","role":"author","urls":{"Paper":"http://www.ncbi.nlm.nih.gov/pubmed/30867275 https://n.neurology.org/content/92/15/e1669.long"},"keyword":["Aged Blood-Brain Barrier/diagnostic imaging/*pathology Cerebral Small Vessel Diseases/diagnostic imaging/*pathology Cerebrospinal Fluid Leak/pathology Cerebrovascular Circulation Cerebrovascular Disorders/diagnostic imaging/*pathology Contrast Media Female Gadolinium Humans Magnetic Resonance Imaging Male Middle Aged White Matter/diagnostic imaging"],"metadata":{"authorlinks":{"jansen, j":"https://www.jansenjfa.com/publications/"}},"downloads":0,"html":""},"search_terms":["blood","brain","barrier","impairment","hypoperfusion","linked","cerebral","small","vessel","disease","wong","jansen","zhang","hoff","staals","van oostenbrugge","backes"],"keywords":["aged blood-brain barrier/diagnostic imaging/*pathology cerebral small vessel diseases/diagnostic imaging/*pathology cerebrospinal fluid leak/pathology cerebrovascular circulation cerebrovascular disorders/diagnostic imaging/*pathology contrast media female gadolinium humans magnetic resonance imaging male middle aged white matter/diagnostic imaging"],"authorIDs":["23uhM8poXdb926vJG","3Yjj5LyuY4rysZgP4","4Tm3oPxNFFsEkR6pe","59aae01e5ead235c6f00001d","5df0d93396fa76de0100014e","5df1707557cfb4de0100001d","5dfb0b68a8dc13ee01000092","5e024e386ffa15df0100007a","5e384203ca2b4bde010001ff","5e414cd6b7d170df01000174","5e47cbe8af70c7de0100001a","5e4d7a0d08a8e5de0100019e","5e4ea88f64b624de01000110","5e63862c0ddad9de010000b9","5e685fc7149172de01000144","7YnznfJEbNoLRQfCK","9N7zP6DW8bwFjrrji","9uYiZAT4SGYEdwuhG","C8PsDKLjSCW5NR3p7","CHX5tw5dNmS7tFMt9","DB2BA5PJJ7o8mgnGD","DoNKbgB55xkR6SehT","FEbMpouv9cRyJBZv3","GtL5d4iFpEuoJacN7","H6wbK4u5jYRFL8LDs","HLzbcixmNhduwmTFt","Jeci2sNzJiMSDeJvc","NAFTFJTb9GJgC2h6i","QqoDaykDZWJd9YuAu","RLbGKAvkbQAw2q2pz","SEoD5FrxRgf2DKcTT","TCejZCDssndxpTcJg","TEAWLnKpXtQE8hs6C","dGQk363jLcfCvKxGW","dR2ye6bifAsonnNMz","eJ9fizm2KNxBgiNfF","ejNE5EpaKtPzpHp79","gxe8DkJ5qKbznZgZq","hGdeHv63Gb3m6CybW","hShritfXo7Lzr2RkJ","jDvmx9aE5aohaf7P7","rQrciQZhPyL9ovwM8","ryLRyF5HAWnpncbbr","sFGhcvCCManvCwLHz","txfqjmhcnxmvnAv2m","zTR82AHQxLXLWt4wi"],"dataSources":["NcYBKGxxHQiyceke2","TCkfRWJAZvbLAZi29"]}