@article{RN203,
   author = {Wong, S. M. and Jansen, J. F. A. and Zhang, C. E. and Staals, J. and Hofman, P. A. M. and van Oostenbrugge, R. J. and Jeukens, Crlpn and Backes, W. H.},
   title = {Measuring subtle leakage of the blood-brain barrier in cerebrovascular disease with DCE-MRI: Test-retest reproducibility and its influencing factors},
   journal = {J Magn Reson Imaging},
   volume = {46},
   number = {1},
   pages = {159-166},
   note = {Wong, Sau May
Jansen, Jacobus F A
Zhang, C Eleana
Staals, Julie
Hofman, Paul A M
van Oostenbrugge, Robert J
Jeukens, Cecile R L P N
Backes, Walter H
eng
Evaluation Study
2017/02/06 06:00
J Magn Reson Imaging. 2017 Jul;46(1):159-166. doi: 10.1002/jmri.25540. Epub 2017 Feb 3.},
   abstract = {PURPOSE: Increased blood-brain barrier (BBB) permeability has been shown to play a significant role in the pathophysiology of cerebrovascular disease and it may provide an early functional marker of progression or treatment effects. The aim of the study was to investigate the test-retest reproducibility and influencing factors of dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) in measuring subtle leakage in patients with cerebrovascular disease. MATERIAL AND METHODS: DCE-MRI (3T) was performed on two separate days in 16 patients (age 66 +/- 9 years) with cerebrovascular disease, prospectively. The leakage rate was quantified for white matter (WM) and gray matter (GM) using the Patlak graphical approach with individual vascular input functions (VIFs). Furthermore, the influence of session-averaged VIFs, the average of the VIFs obtained on two days, and shorter scan times (range 5-25 minutes) on the reproducibility were evaluated in WM and GM. RESULTS: Coefficients of variation (CV) </=14.4% (WM and GM), intraclass correlation coefficients (ICCs) of 0.77 (WM) and 0.49 (GM), were observed for the leakage rate. Session-averaged VIFs hardly affected these results (CV </=13.4%). The repeatability coefficients (RCs) of the leakage rate decreased from 2.7.10(-3) to 0.4.10(-3) min(-1) in WM (P < 0.01) and 4.4.10(-3) to 0.9.10(-3) min(-1) in GM (P < 0.01) with increasing scan time (range 5-25 minutes). CONCLUSION: Based on the moderate CVs and moderate-to-excellent ICCs, we demonstrate that measuring subtle BBB leakage using DCE-MRI is moderate-to-excellent reproducible. Longer scan times improve the reproducibility. The provided RCs at various scan times may assist future clinical studies investigating BBB leakage using DCE-MRI. LEVEL OF EVIDENCE: 2 Technical Efficacy: Stage 2 J. MAGN. RESON. IMAGING 2017;46:159-166.},
   keywords = {Aged
Blood-Brain Barrier/*diagnostic imaging
Capillary Permeability
Cerebral Hemorrhage/*diagnostic imaging/etiology
Cerebrovascular Disorders/complications/*diagnostic imaging
Contrast Media
Female
Humans
Image Interpretation, Computer-Assisted/*methods
Magnetic Resonance Angiography/*methods
Male
Reproducibility of Results
Sensitivity and Specificity
*blood-brain barrier
*cerebrovascular disease
*dynamic contrast-enhanced magnetic resonance imaging
*permeability
*reproducibility},
   ISSN = {1522-2586 (Electronic)
1053-1807 (Linking)},
   DOI = {10.1002/jmri.25540},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/28160347
https://onlinelibrary.wiley.com/doi/abs/10.1002/jmri.25540},
   year = {2017},
   type = {Journal Article}
}

{"_id":"67F4Af8txotBNxopC","bibbaseid":"wong-jansen-zhang-staals-hofman-vanoostenbrugge-jeukens-backes-measuringsubtleleakageofthebloodbrainbarrierincerebrovasculardiseasewithdcemritestretestreproducibilityanditsinfluencingfactors-2017","downloads":0,"creationDate":"2017-09-02T16:45:18.648Z","title":"Measuring subtle leakage of the blood-brain barrier in cerebrovascular disease with DCE-MRI: Test-retest reproducibility and its influencing factors","author_short":["Wong, S. M.","Jansen, J. F. A.","Zhang, C. E.","Staals, J.","Hofman, P. A. M.","van Oostenbrugge, R. J.","Jeukens, C.","Backes, W. H."],"year":2017,"bibtype":"article","biburl":"https://raw.githubusercontent.com/jansenjfa1/bibbase.github.io/master/jansenjfa.bib","bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Wong"],"firstnames":["S.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Zhang"],"firstnames":["C.","E."],"suffixes":[]},{"propositions":[],"lastnames":["Staals"],"firstnames":["J."],"suffixes":[]},{"propositions":[],"lastnames":["Hofman"],"firstnames":["P.","A.","M."],"suffixes":[]},{"propositions":["van"],"lastnames":["Oostenbrugge"],"firstnames":["R.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Jeukens"],"firstnames":["Crlpn"],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W.","H."],"suffixes":[]}],"title":"Measuring subtle leakage of the blood-brain barrier in cerebrovascular disease with DCE-MRI: Test-retest reproducibility and its influencing factors","journal":"J Magn Reson Imaging","volume":"46","number":"1","pages":"159-166","note":"Wong, Sau May Jansen, Jacobus F A Zhang, C Eleana Staals, Julie Hofman, Paul A M van Oostenbrugge, Robert J Jeukens, Cecile R L P N Backes, Walter H eng Evaluation Study 2017/02/06 06:00 J Magn Reson Imaging. 2017 Jul;46(1):159-166. doi: 10.1002/jmri.25540. Epub 2017 Feb 3.","abstract":"PURPOSE: Increased blood-brain barrier (BBB) permeability has been shown to play a significant role in the pathophysiology of cerebrovascular disease and it may provide an early functional marker of progression or treatment effects. The aim of the study was to investigate the test-retest reproducibility and influencing factors of dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) in measuring subtle leakage in patients with cerebrovascular disease. MATERIAL AND METHODS: DCE-MRI (3T) was performed on two separate days in 16 patients (age 66 +/- 9 years) with cerebrovascular disease, prospectively. The leakage rate was quantified for white matter (WM) and gray matter (GM) using the Patlak graphical approach with individual vascular input functions (VIFs). Furthermore, the influence of session-averaged VIFs, the average of the VIFs obtained on two days, and shorter scan times (range 5-25 minutes) on the reproducibility were evaluated in WM and GM. RESULTS: Coefficients of variation (CV) </=14.4% (WM and GM), intraclass correlation coefficients (ICCs) of 0.77 (WM) and 0.49 (GM), were observed for the leakage rate. Session-averaged VIFs hardly affected these results (CV </=13.4%). The repeatability coefficients (RCs) of the leakage rate decreased from 2.7.10(-3) to 0.4.10(-3) min(-1) in WM (P < 0.01) and 4.4.10(-3) to 0.9.10(-3) min(-1) in GM (P < 0.01) with increasing scan time (range 5-25 minutes). CONCLUSION: Based on the moderate CVs and moderate-to-excellent ICCs, we demonstrate that measuring subtle BBB leakage using DCE-MRI is moderate-to-excellent reproducible. Longer scan times improve the reproducibility. The provided RCs at various scan times may assist future clinical studies investigating BBB leakage using DCE-MRI. LEVEL OF EVIDENCE: 2 Technical Efficacy: Stage 2 J. MAGN. RESON. IMAGING 2017;46:159-166.","keywords":"Aged Blood-Brain Barrier/*diagnostic imaging Capillary Permeability Cerebral Hemorrhage/*diagnostic imaging/etiology Cerebrovascular Disorders/complications/*diagnostic imaging Contrast Media Female Humans Image Interpretation, Computer-Assisted/*methods Magnetic Resonance Angiography/*methods Male Reproducibility of Results Sensitivity and Specificity *blood-brain barrier *cerebrovascular disease *dynamic contrast-enhanced magnetic resonance imaging *permeability *reproducibility","issn":"1522-2586 (Electronic) 1053-1807 (Linking)","doi":"10.1002/jmri.25540","url":"http://www.ncbi.nlm.nih.gov/pubmed/28160347 https://onlinelibrary.wiley.com/doi/abs/10.1002/jmri.25540","year":"2017","bibtex":"@article{RN203,\n author = {Wong, S. M. and Jansen, J. F. A. and Zhang, C. E. and Staals, J. and Hofman, P. A. M. and van Oostenbrugge, R. J. and Jeukens, Crlpn and Backes, W. H.},\n title = {Measuring subtle leakage of the blood-brain barrier in cerebrovascular disease with DCE-MRI: Test-retest reproducibility and its influencing factors},\n journal = {J Magn Reson Imaging},\n volume = {46},\n number = {1},\n pages = {159-166},\n note = {Wong, Sau May\nJansen, Jacobus F A\nZhang, C Eleana\nStaals, Julie\nHofman, Paul A M\nvan Oostenbrugge, Robert J\nJeukens, Cecile R L P N\nBackes, Walter H\neng\nEvaluation Study\n2017/02/06 06:00\nJ Magn Reson Imaging. 2017 Jul;46(1):159-166. doi: 10.1002/jmri.25540. Epub 2017 Feb 3.},\n abstract = {PURPOSE: Increased blood-brain barrier (BBB) permeability has been shown to play a significant role in the pathophysiology of cerebrovascular disease and it may provide an early functional marker of progression or treatment effects. The aim of the study was to investigate the test-retest reproducibility and influencing factors of dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) in measuring subtle leakage in patients with cerebrovascular disease. MATERIAL AND METHODS: DCE-MRI (3T) was performed on two separate days in 16 patients (age 66 +/- 9 years) with cerebrovascular disease, prospectively. The leakage rate was quantified for white matter (WM) and gray matter (GM) using the Patlak graphical approach with individual vascular input functions (VIFs). Furthermore, the influence of session-averaged VIFs, the average of the VIFs obtained on two days, and shorter scan times (range 5-25 minutes) on the reproducibility were evaluated in WM and GM. RESULTS: Coefficients of variation (CV) </=14.4% (WM and GM), intraclass correlation coefficients (ICCs) of 0.77 (WM) and 0.49 (GM), were observed for the leakage rate. Session-averaged VIFs hardly affected these results (CV </=13.4%). The repeatability coefficients (RCs) of the leakage rate decreased from 2.7.10(-3) to 0.4.10(-3) min(-1) in WM (P < 0.01) and 4.4.10(-3) to 0.9.10(-3) min(-1) in GM (P < 0.01) with increasing scan time (range 5-25 minutes). CONCLUSION: Based on the moderate CVs and moderate-to-excellent ICCs, we demonstrate that measuring subtle BBB leakage using DCE-MRI is moderate-to-excellent reproducible. Longer scan times improve the reproducibility. The provided RCs at various scan times may assist future clinical studies investigating BBB leakage using DCE-MRI. LEVEL OF EVIDENCE: 2 Technical Efficacy: Stage 2 J. MAGN. RESON. IMAGING 2017;46:159-166.},\n keywords = {Aged\nBlood-Brain Barrier/*diagnostic imaging\nCapillary Permeability\nCerebral Hemorrhage/*diagnostic imaging/etiology\nCerebrovascular Disorders/complications/*diagnostic imaging\nContrast Media\nFemale\nHumans\nImage Interpretation, Computer-Assisted/*methods\nMagnetic Resonance Angiography/*methods\nMale\nReproducibility of Results\nSensitivity and Specificity\n*blood-brain barrier\n*cerebrovascular disease\n*dynamic contrast-enhanced magnetic resonance imaging\n*permeability\n*reproducibility},\n ISSN = {1522-2586 (Electronic)\n1053-1807 (Linking)},\n DOI = {10.1002/jmri.25540},\n url = {http://www.ncbi.nlm.nih.gov/pubmed/28160347\nhttps://onlinelibrary.wiley.com/doi/abs/10.1002/jmri.25540},\n year = {2017},\n type = {Journal Article}\n}\n\n","author_short":["Wong, S. M.","Jansen, J. F. A.","Zhang, C. E.","Staals, J.","Hofman, P. A. M.","van Oostenbrugge, R. J.","Jeukens, C.","Backes, W. 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