@article{RN204,
   author = {Wong, S. M. and Zhang, C. E. and van Bussel, F. C. and Staals, J. and Jeukens, C. R. and Hofman, P. A. and van Oostenbrugge, R. J. and Backes, W. H. and Jansen, J. F.},
   title = {Simultaneous investigation of microvasculature and parenchyma in cerebral small vessel disease using intravoxel incoherent motion imaging},
   journal = {Neuroimage Clin},
   volume = {14},
   pages = {216-221},
   note = {Wong, Sau May
Zhang, C Eleana
van Bussel, Frank C G
Staals, Julie
Jeukens, Cecile R L P N
Hofman, Paul A M
van Oostenbrugge, Robert J
Backes, Walter H
Jansen, Jacobus F A
eng
Research Support, Non-U.S. Gov't
Netherlands
2017/02/10 06:00
Neuroimage Clin. 2017 Jan 17;14:216-221. doi: 10.1016/j.nicl.2017.01.017. eCollection 2017.},
   abstract = {INTRODUCTION: Cerebral small vessel disease (cSVD) is associated with microvascular and parenchymal alterations. Intravoxel incoherent motion (IVIM) MRI has been proposed to simultaneously measure both the microvascular perfusion and parenchymal diffusivity. This study aimed to evaluate the application of IVIM in cSVD to assess the microvasculature and parenchymal microstructure. METHODS: Seventy-three patients with cSVD (age 70 +/- 11 y) and thirty-nine controls (age 69 +/- 12 y) underwent IVIM imaging (3T). Group differences of the perfusion volume fraction f and the parenchymal diffusivity D were investigated using multivariable linear regression accounted for age, sex and cardiovascular factors. To examine the relation between the IVIM measures and the disease severity on structural MRI, white matter hyperintensity (WMH) load served as surrogate measure of the disease severity. RESULTS: Patients had a larger f (p < 0.024) in the normal appearing white matter (NAWM) than controls. Higher D (p < 0.031) was also observed for patients compared with controls in the NAWM and grey matter. Both f (p < 0.024) and D (p < 0.001) in the NAWM and grey matter increased with WMH load. CONCLUSIONS: The increased diffusivity reflects the predicted microstructural tissue impairment in cSVD. Unexpectedly, an increased perfusion volume fraction was observed in patients. Future studies are needed to reveal the precise nature of the increased perfusion volume fraction. IVIM imaging showed that the increases of f and D in cSVD were both related to disease severity, which suggests the potential of IVIM imaging to provide a surrogate marker for the progression of cSVD.},
   keywords = {Aged
Aged, 80 and over
Cerebral Small Vessel Diseases/*diagnostic imaging
Diffusion Magnetic Resonance Imaging
Female
Humans
Magnetic Resonance Imaging
Male
Microvessels/*diagnostic imaging
Middle Aged
Motion
Parenchymal Tissue/*diagnostic imaging
Perfusion
Retrospective Studies
White Matter/diagnostic imaging
*BMI, body mass index
*Brain parenchyma
*Cerebral small vessel disease
*DGM, deep grey matter
*DW, diffusion weighted
*Diffusion weighted imaging
*FLAIR, fluid attenuated inversion recovery
*FOV, field of view
*IVIM, intravoxel incoherent motion imaging
*Intravoxel incoherent motion imaging
*LS, lacunar stroke
*Microvasculature
*NAWM, normal appearing white matter
*PVS, perivascular spaces
*Perfusion MR imaging
*ROI, region of interest
*SNR, signal-to-noise ratio
*WMH, white matter hyperintensity
*cSVD, cerebral small vessel disease
*mVCI, mild vascular cognitive impairment},
   ISSN = {2213-1582 (Electronic)
2213-1582 (Linking)},
   DOI = {10.1016/j.nicl.2017.01.017},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/28180080
https://pdf.sciencedirectassets.com/282794/1-s2.0-S2213158217X00028/1-s2.0-S2213158217300177/main.pdf?X-Amz-Security-Token=IQoJb3JpZ2luX2VjEF8aCXVzLWVhc3QtMSJGMEQCIAQmfuy0YpnpzA06IvgaJRer3eGZ8rdXKqrGEPxuY4hwAiAhNsNkOr54wVYDjzIe0TIfoTD8kqLEdfRU41qZmLh6kCq0Awh3EAMaDDA1OTAwMzU0Njg2NSIMlXt1Xqb4dxeUi0MRKpEDXZ4M8CPLoGf8msYDwMgDx56imvY2%2FFHUoxS4CM1EMFuLroTNFelQ8BygJLg0staUoEQIEuTGuBDtUAQPbMOjVKqWdzRFnutlpydeHADe9ctTnbSGJXr4jSWpCWI0Duez%2FERsZRAaT8I395CSeZdqhuTwMrfUCd%2B7gwzJj96AHbB5fZ8enuunohOKyF7ql70gTR2W3460U%2BWxhZywqWQhFzLA2JJJZ07JW31%2FHar%2BD4%2FVtKv%2FLtjHEtsrlHBskyQBrqNOjfsJnJAe%2BDzBFjAx62YeRgWzLmTDWDmlDwKrA96XIIAyiNC8LnSeAJlceAEskuRq7YUH5qxBzYKSw7%2F0%2BAaEPMCsQuWiNr2z4g1xkoQ4YkjUZxalogFs2QfDb63vIH%2F%2B2LIrjqaQymu2xseB8aF3zv4tidEMVBJ3hHRfFZLjY9CjMh505CngDts7usguzw4eomFgqlKV52LeKNQO7qFU4DFoQdlKFZ54NvOnf7hVL5144mmkNQCW%2F53Svlew0g1IHq42Uuc%2BVgeEyLda%2BDswkInX9AU67AHXqmV3YcX925%2FL2M98Efr6Z7jaJ%2BFFd1gO%2BGYlG0cJjezJf7sRrPxU4Y%2FwvNtOcBeUcAldo59O10%2BwhCR0K3Upg3ixzWDuHbOpUc%2BPjnaafCBynkkSRsPrk1%2FwADyaY4BjhGowdmeKpjFu148kOPFtlZZ%2FSVE7zcLwT%2BVOWP2KC7tV2%2B%2FpcEETSLVqUFth2dBSrQiUWF07yKQ2bznZc%2B9Am0A0s1on1DZ9AhWfpxgv9CjbRV0rOrAkgTwcSP7Pa9rMIZXuoD%2BYaZsyzKPI9gh4Upkl50Ch8Ys%2FKE8s9hH1Tk2XFO1D9KSSB9dCUQ%3D%3D&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20200414T144241Z&X-Amz-SignedHeaders=host&X-Amz-Expires=300&X-Amz-Credential=ASIAQ3PHCVTY3VVVZMTI%2F20200414%2Fus-east-1%2Fs3%2Faws4_request&X-Amz-Signature=1adc126f45ff32033684db857e838a28818773dfcb266fede34dcf113d19f88a&hash=de06df4841d2a25b20cbf419324ee5604566d5fcd21619a514dbb34abcf808d9&host=68042c943591013ac2b2430a89b270f6af2c76d8dfd086a07176afe7c76c2c61&pii=S2213158217300177&tid=spdf-4ebad36b-3287-4200-8188-4ab110f05e7b&sid=011858f4477d9942d7581a16e4804d44a9c6gxrqb&type=client
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288390/pdf/main.pdf},
   year = {2017},
   type = {Journal Article}
}

{"_id":"jQrShEs4StkohafFx","bibbaseid":"wong-zhang-vanbussel-staals-jeukens-hofman-vanoostenbrugge-backes-etal-simultaneousinvestigationofmicrovasculatureandparenchymaincerebralsmallvesseldiseaseusingintravoxelincoherentmotionimaging-2017","downloads":0,"creationDate":"2017-09-02T16:45:18.626Z","title":"Simultaneous investigation of microvasculature and parenchyma in cerebral small vessel disease using intravoxel incoherent motion imaging","author_short":["Wong, S. M.","Zhang, C. E.","van Bussel, F. C.","Staals, J.","Jeukens, C. R.","Hofman, P. A.","van Oostenbrugge, R. J.","Backes, W. H.","Jansen, J. F."],"year":2017,"bibtype":"article","biburl":"https://raw.githubusercontent.com/jansenjfa1/bibbase.github.io/master/jansenjfa.bib","bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Wong"],"firstnames":["S.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Zhang"],"firstnames":["C.","E."],"suffixes":[]},{"propositions":["van"],"lastnames":["Bussel"],"firstnames":["F.","C."],"suffixes":[]},{"propositions":[],"lastnames":["Staals"],"firstnames":["J."],"suffixes":[]},{"propositions":[],"lastnames":["Jeukens"],"firstnames":["C.","R."],"suffixes":[]},{"propositions":[],"lastnames":["Hofman"],"firstnames":["P.","A."],"suffixes":[]},{"propositions":["van"],"lastnames":["Oostenbrugge"],"firstnames":["R.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F."],"suffixes":[]}],"title":"Simultaneous investigation of microvasculature and parenchyma in cerebral small vessel disease using intravoxel incoherent motion imaging","journal":"Neuroimage Clin","volume":"14","pages":"216-221","note":"Wong, Sau May Zhang, C Eleana van Bussel, Frank C G Staals, Julie Jeukens, Cecile R L P N Hofman, Paul A M van Oostenbrugge, Robert J Backes, Walter H Jansen, Jacobus F A eng Research Support, Non-U.S. Gov't Netherlands 2017/02/10 06:00 Neuroimage Clin. 2017 Jan 17;14:216-221. doi: 10.1016/j.nicl.2017.01.017. eCollection 2017.","abstract":"INTRODUCTION: Cerebral small vessel disease (cSVD) is associated with microvascular and parenchymal alterations. Intravoxel incoherent motion (IVIM) MRI has been proposed to simultaneously measure both the microvascular perfusion and parenchymal diffusivity. This study aimed to evaluate the application of IVIM in cSVD to assess the microvasculature and parenchymal microstructure. METHODS: Seventy-three patients with cSVD (age 70 +/- 11 y) and thirty-nine controls (age 69 +/- 12 y) underwent IVIM imaging (3T). Group differences of the perfusion volume fraction f and the parenchymal diffusivity D were investigated using multivariable linear regression accounted for age, sex and cardiovascular factors. To examine the relation between the IVIM measures and the disease severity on structural MRI, white matter hyperintensity (WMH) load served as surrogate measure of the disease severity. RESULTS: Patients had a larger f (p < 0.024) in the normal appearing white matter (NAWM) than controls. Higher D (p < 0.031) was also observed for patients compared with controls in the NAWM and grey matter. Both f (p < 0.024) and D (p < 0.001) in the NAWM and grey matter increased with WMH load. CONCLUSIONS: The increased diffusivity reflects the predicted microstructural tissue impairment in cSVD. Unexpectedly, an increased perfusion volume fraction was observed in patients. Future studies are needed to reveal the precise nature of the increased perfusion volume fraction. IVIM imaging showed that the increases of f and D in cSVD were both related to disease severity, which suggests the potential of IVIM imaging to provide a surrogate marker for the progression of cSVD.","keywords":"Aged Aged, 80 and over Cerebral Small Vessel Diseases/*diagnostic imaging Diffusion Magnetic Resonance Imaging Female Humans Magnetic Resonance Imaging Male Microvessels/*diagnostic imaging Middle Aged Motion Parenchymal Tissue/*diagnostic imaging Perfusion Retrospective Studies White Matter/diagnostic imaging *BMI, body mass index *Brain parenchyma *Cerebral small vessel disease *DGM, deep grey matter *DW, diffusion weighted *Diffusion weighted imaging *FLAIR, fluid attenuated inversion recovery *FOV, field of view *IVIM, intravoxel incoherent motion imaging *Intravoxel incoherent motion imaging *LS, lacunar stroke *Microvasculature *NAWM, normal appearing white matter *PVS, perivascular spaces *Perfusion MR imaging *ROI, region of interest *SNR, signal-to-noise ratio *WMH, white matter hyperintensity *cSVD, cerebral small vessel disease *mVCI, mild vascular cognitive impairment","issn":"2213-1582 (Electronic) 2213-1582 (Linking)","doi":"10.1016/j.nicl.2017.01.017","url":"http://www.ncbi.nlm.nih.gov/pubmed/28180080 https://pdf.sciencedirectassets.com/282794/1-s2.0-S2213158217X00028/1-s2.0-S2213158217300177/main.pdf?X-Amz-Security-Token=IQoJb3JpZ2luX2VjEF8aCXVzLWVhc3QtMSJGMEQCIAQmfuy0YpnpzA06IvgaJRer3eGZ8rdXKqrGEPxuY4hwAiAhNsNkOr54wVYDjzIe0TIfoTD8kqLEdfRU41qZmLh6kCq0Awh3EAMaDDA1OTAwMzU0Njg2NSIMlXt1Xqb4dxeUi0MRKpEDXZ4M8CPLoGf8msYDwMgDx56imvY2%2FFHUoxS4CM1EMFuLroTNFelQ8BygJLg0staUoEQIEuTGuBDtUAQPbMOjVKqWdzRFnutlpydeHADe9ctTnbSGJXr4jSWpCWI0Duez%2FERsZRAaT8I395CSeZdqhuTwMrfUCd%2B7gwzJj96AHbB5fZ8enuunohOKyF7ql70gTR2W3460U%2BWxhZywqWQhFzLA2JJJZ07JW31%2FHar%2BD4%2FVtKv%2FLtjHEtsrlHBskyQBrqNOjfsJnJAe%2BDzBFjAx62YeRgWzLmTDWDmlDwKrA96XIIAyiNC8LnSeAJlceAEskuRq7YUH5qxBzYKSw7%2F0%2BAaEPMCsQuWiNr2z4g1xkoQ4YkjUZxalogFs2QfDb63vIH%2F%2B2LIrjqaQymu2xseB8aF3zv4tidEMVBJ3hHRfFZLjY9CjMh505CngDts7usguzw4eomFgqlKV52LeKNQO7qFU4DFoQdlKFZ54NvOnf7hVL5144mmkNQCW%2F53Svlew0g1IHq42Uuc%2BVgeEyLda%2BDswkInX9AU67AHXqmV3YcX925%2FL2M98Efr6Z7jaJ%2BFFd1gO%2BGYlG0cJjezJf7sRrPxU4Y%2FwvNtOcBeUcAldo59O10%2BwhCR0K3Upg3ixzWDuHbOpUc%2BPjnaafCBynkkSRsPrk1%2FwADyaY4BjhGowdmeKpjFu148kOPFtlZZ%2FSVE7zcLwT%2BVOWP2KC7tV2%2B%2FpcEETSLVqUFth2dBSrQiUWF07yKQ2bznZc%2B9Am0A0s1on1DZ9AhWfpxgv9CjbRV0rOrAkgTwcSP7Pa9rMIZXuoD%2BYaZsyzKPI9gh4Upkl50Ch8Ys%2FKE8s9hH1Tk2XFO1D9KSSB9dCUQ%3D%3D&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20200414T144241Z&X-Amz-SignedHeaders=host&X-Amz-Expires=300&X-Amz-Credential=ASIAQ3PHCVTY3VVVZMTI%2F20200414%2Fus-east-1%2Fs3%2Faws4_request&X-Amz-Signature=1adc126f45ff32033684db857e838a28818773dfcb266fede34dcf113d19f88a&hash=de06df4841d2a25b20cbf419324ee5604566d5fcd21619a514dbb34abcf808d9&host=68042c943591013ac2b2430a89b270f6af2c76d8dfd086a07176afe7c76c2c61&pii=S2213158217300177&tid=spdf-4ebad36b-3287-4200-8188-4ab110f05e7b&sid=011858f4477d9942d7581a16e4804d44a9c6gxrqb&type=client https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288390/pdf/main.pdf","year":"2017","bibtex":"@article{RN204,\n author = {Wong, S. M. and Zhang, C. E. and van Bussel, F. C. and Staals, J. and Jeukens, C. R. and Hofman, P. A. and van Oostenbrugge, R. J. and Backes, W. H. and Jansen, J. F.},\n title = {Simultaneous investigation of microvasculature and parenchyma in cerebral small vessel disease using intravoxel incoherent motion imaging},\n journal = {Neuroimage Clin},\n volume = {14},\n pages = {216-221},\n note = {Wong, Sau May\nZhang, C Eleana\nvan Bussel, Frank C G\nStaals, Julie\nJeukens, Cecile R L P N\nHofman, Paul A M\nvan Oostenbrugge, Robert J\nBackes, Walter H\nJansen, Jacobus F A\neng\nResearch Support, Non-U.S. Gov't\nNetherlands\n2017/02/10 06:00\nNeuroimage Clin. 2017 Jan 17;14:216-221. doi: 10.1016/j.nicl.2017.01.017. eCollection 2017.},\n abstract = {INTRODUCTION: Cerebral small vessel disease (cSVD) is associated with microvascular and parenchymal alterations. Intravoxel incoherent motion (IVIM) MRI has been proposed to simultaneously measure both the microvascular perfusion and parenchymal diffusivity. This study aimed to evaluate the application of IVIM in cSVD to assess the microvasculature and parenchymal microstructure. METHODS: Seventy-three patients with cSVD (age 70 +/- 11 y) and thirty-nine controls (age 69 +/- 12 y) underwent IVIM imaging (3T). Group differences of the perfusion volume fraction f and the parenchymal diffusivity D were investigated using multivariable linear regression accounted for age, sex and cardiovascular factors. To examine the relation between the IVIM measures and the disease severity on structural MRI, white matter hyperintensity (WMH) load served as surrogate measure of the disease severity. RESULTS: Patients had a larger f (p < 0.024) in the normal appearing white matter (NAWM) than controls. Higher D (p < 0.031) was also observed for patients compared with controls in the NAWM and grey matter. Both f (p < 0.024) and D (p < 0.001) in the NAWM and grey matter increased with WMH load. CONCLUSIONS: The increased diffusivity reflects the predicted microstructural tissue impairment in cSVD. Unexpectedly, an increased perfusion volume fraction was observed in patients. Future studies are needed to reveal the precise nature of the increased perfusion volume fraction. IVIM imaging showed that the increases of f and D in cSVD were both related to disease severity, which suggests the potential of IVIM imaging to provide a surrogate marker for the progression of cSVD.},\n keywords = {Aged\nAged, 80 and over\nCerebral Small Vessel Diseases/*diagnostic imaging\nDiffusion Magnetic Resonance Imaging\nFemale\nHumans\nMagnetic Resonance Imaging\nMale\nMicrovessels/*diagnostic imaging\nMiddle Aged\nMotion\nParenchymal Tissue/*diagnostic imaging\nPerfusion\nRetrospective Studies\nWhite Matter/diagnostic imaging\n*BMI, body mass index\n*Brain parenchyma\n*Cerebral small vessel disease\n*DGM, deep grey matter\n*DW, diffusion weighted\n*Diffusion weighted imaging\n*FLAIR, fluid attenuated inversion recovery\n*FOV, field of view\n*IVIM, intravoxel incoherent motion imaging\n*Intravoxel incoherent motion imaging\n*LS, lacunar stroke\n*Microvasculature\n*NAWM, normal appearing white matter\n*PVS, perivascular spaces\n*Perfusion MR imaging\n*ROI, region of interest\n*SNR, signal-to-noise ratio\n*WMH, white matter hyperintensity\n*cSVD, cerebral small vessel disease\n*mVCI, mild vascular cognitive impairment},\n ISSN = {2213-1582 (Electronic)\n2213-1582 (Linking)},\n DOI = {10.1016/j.nicl.2017.01.017},\n url = {http://www.ncbi.nlm.nih.gov/pubmed/28180080\nhttps://pdf.sciencedirectassets.com/282794/1-s2.0-S2213158217X00028/1-s2.0-S2213158217300177/main.pdf?X-Amz-Security-Token=IQoJb3JpZ2luX2VjEF8aCXVzLWVhc3QtMSJGMEQCIAQmfuy0YpnpzA06IvgaJRer3eGZ8rdXKqrGEPxuY4hwAiAhNsNkOr54wVYDjzIe0TIfoTD8kqLEdfRU41qZmLh6kCq0Awh3EAMaDDA1OTAwMzU0Njg2NSIMlXt1Xqb4dxeUi0MRKpEDXZ4M8CPLoGf8msYDwMgDx56imvY2%2FFHUoxS4CM1EMFuLroTNFelQ8BygJLg0staUoEQIEuTGuBDtUAQPbMOjVKqWdzRFnutlpydeHADe9ctTnbSGJXr4jSWpCWI0Duez%2FERsZRAaT8I395CSeZdqhuTwMrfUCd%2B7gwzJj96AHbB5fZ8enuunohOKyF7ql70gTR2W3460U%2BWxhZywqWQhFzLA2JJJZ07JW31%2FHar%2BD4%2FVtKv%2FLtjHEtsrlHBskyQBrqNOjfsJnJAe%2BDzBFjAx62YeRgWzLmTDWDmlDwKrA96XIIAyiNC8LnSeAJlceAEskuRq7YUH5qxBzYKSw7%2F0%2BAaEPMCsQuWiNr2z4g1xkoQ4YkjUZxalogFs2QfDb63vIH%2F%2B2LIrjqaQymu2xseB8aF3zv4tidEMVBJ3hHRfFZLjY9CjMh505CngDts7usguzw4eomFgqlKV52LeKNQO7qFU4DFoQdlKFZ54NvOnf7hVL5144mmkNQCW%2F53Svlew0g1IHq42Uuc%2BVgeEyLda%2BDswkInX9AU67AHXqmV3YcX925%2FL2M98Efr6Z7jaJ%2BFFd1gO%2BGYlG0cJjezJf7sRrPxU4Y%2FwvNtOcBeUcAldo59O10%2BwhCR0K3Upg3ixzWDuHbOpUc%2BPjnaafCBynkkSRsPrk1%2FwADyaY4BjhGowdmeKpjFu148kOPFtlZZ%2FSVE7zcLwT%2BVOWP2KC7tV2%2B%2FpcEETSLVqUFth2dBSrQiUWF07yKQ2bznZc%2B9Am0A0s1on1DZ9AhWfpxgv9CjbRV0rOrAkgTwcSP7Pa9rMIZXuoD%2BYaZsyzKPI9gh4Upkl50Ch8Ys%2FKE8s9hH1Tk2XFO1D9KSSB9dCUQ%3D%3D&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20200414T144241Z&X-Amz-SignedHeaders=host&X-Amz-Expires=300&X-Amz-Credential=ASIAQ3PHCVTY3VVVZMTI%2F20200414%2Fus-east-1%2Fs3%2Faws4_request&X-Amz-Signature=1adc126f45ff32033684db857e838a28818773dfcb266fede34dcf113d19f88a&hash=de06df4841d2a25b20cbf419324ee5604566d5fcd21619a514dbb34abcf808d9&host=68042c943591013ac2b2430a89b270f6af2c76d8dfd086a07176afe7c76c2c61&pii=S2213158217300177&tid=spdf-4ebad36b-3287-4200-8188-4ab110f05e7b&sid=011858f4477d9942d7581a16e4804d44a9c6gxrqb&type=client\nhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288390/pdf/main.pdf},\n year = {2017},\n type = {Journal Article}\n}\n\n","author_short":["Wong, S. M.","Zhang, C. E.","van Bussel, F. C.","Staals, J.","Jeukens, C. R.","Hofman, P. A.","van Oostenbrugge, R. J.","Backes, W. H.","Jansen, J. 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