High heritability for a composite index of children's activity level measures. Wood, A. C, Rijsdijk, F., Saudino, K. J, Asherson, P., & Kuntsi, J. Behavior genetics, 38(3):266–76, May, 2008. ![High heritability for a composite index of children's activity level measures. [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Despite the high heritability of children's activity level, which forms part of the core symptom domain of hyperactivity-impulsivity within attention deficit hyperactivity disorder (ADHD), there has only been a limited success with identifying candidate genes involved in its etiology. This may reflect a lack of understanding about the different measures used to define activity level across studies. We aimed to study the genetic and environmental etiology across three measures of activity level: parent and teacher ratings of hyperactivity-impulsivity and actigraph measurements, within a population-based sample of 463 7-9 year old twin pairs. We further examined ways in which the three measures could be combined for future molecular studies. Phenotypic correlations across measures were modest, but a common underlying phenotypic factor was highly heritable (92%); as was a simple aggregation of all three measurements (77%). This suggests that distilling what is common to all three measures may be a good method for generating a quantitative trait suitable for molecular studies of activity level in children. The high heritabilities found are encouraging in this respect.
@article{wood_high_2008,
title = {High heritability for a composite index of children's activity level measures.},
volume = {38},
issn = {0001-8244},
url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2493057&tool=pmcentrez&rendertype=abstract},
doi = {10.1007/s10519-008-9196-1},
abstract = {Despite the high heritability of children's activity level, which forms part of the core symptom domain of hyperactivity-impulsivity within attention deficit hyperactivity disorder (ADHD), there has only been a limited success with identifying candidate genes involved in its etiology. This may reflect a lack of understanding about the different measures used to define activity level across studies. We aimed to study the genetic and environmental etiology across three measures of activity level: parent and teacher ratings of hyperactivity-impulsivity and actigraph measurements, within a population-based sample of 463 7-9 year old twin pairs. We further examined ways in which the three measures could be combined for future molecular studies. Phenotypic correlations across measures were modest, but a common underlying phenotypic factor was highly heritable (92\%); as was a simple aggregation of all three measurements (77\%). This suggests that distilling what is common to all three measures may be a good method for generating a quantitative trait suitable for molecular studies of activity level in children. The high heritabilities found are encouraging in this respect.},
number = {3},
urldate = {2015-05-12},
journal = {Behavior genetics},
author = {Wood, Alexis C and Rijsdijk, Frühling and Saudino, Kimberly J and Asherson, Philip and Kuntsi, Jonna},
month = may,
year = {2008},
pmid = {18297388},
keywords = {Attention Deficit and Disruptive Behavior Disorder, Child, Family Health, Female, Genetic Predisposition to Disease, Humans, Impulsive Behavior, Impulsive Behavior: genetics, Male, Models, Genetic, Models, Statistical, Motor Activity, Multivariate Analysis, Parents, Phenotype},
pages = {266--76},
}
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