A centuries-long epidemic of scrapie in British sheep?. Woolhouse, M. E., Coen, P., Matthews, L., Foster, J. D., Elsen, J. M., Lewis, R. M., Haydon, D. T., & Hunter, N. Trends in microbiology, 9(2):67--70, February, 2001. abstract bibtex The apparent persistence of scrapie in British sheep for more than 250 years is difficult to explain. Susceptibility to scrapie is associated with particular alleles at a single locus, the PrP gene. As the only known effect of these alleles is to confer susceptibility to a fatal disease, natural selection is expected to reduce their frequency, as has been observed in practice during scrapie outbreaks in single sheep flocks. Susceptibility alleles, and hence scrapie itself, are therefore expected to become rare, yet the disease remains widespread. We suggest that the paradox of scrapie's persistence can be explained by the exceptionally long time-scales inherent in the epidemiology of the disease. It is proposed that scrapie should be regarded as epidemic in British sheep but, unlike more familiar epidemics, which have time-scales of months or years, the scrapie epidemic has a time-scale of centuries. This interpretation implies that scrapie should eventually disappear from the sheep population.
@article{woolhouse_centuries-long_2001,
title = {A centuries-long epidemic of scrapie in {British} sheep?},
volume = {9},
issn = {0966-842X 0966-842X},
abstract = {The apparent persistence of scrapie in British sheep for more than 250 years is difficult to explain. Susceptibility to scrapie is associated with particular alleles at a single locus, the PrP gene. As the only known effect of these alleles is to confer susceptibility to a fatal disease, natural selection is expected to reduce their frequency, as has been observed in practice during scrapie outbreaks in single sheep flocks. Susceptibility alleles, and hence scrapie itself, are therefore expected to become rare, yet the disease remains widespread. We suggest that the paradox of scrapie's persistence can be explained by the exceptionally long time-scales inherent in the epidemiology of the disease. It is proposed that scrapie should be regarded as epidemic in British sheep but, unlike more familiar epidemics, which have time-scales of months or years, the scrapie epidemic has a time-scale of centuries. This interpretation implies that scrapie should eventually disappear from the sheep population.},
language = {eng},
number = {2},
journal = {Trends in microbiology},
author = {Woolhouse, M. E. and Coen, P. and Matthews, L. and Foster, J. D. and Elsen, J. M. and Lewis, R. M. and Haydon, D. T. and Hunter, N.},
month = feb,
year = {2001},
pmid = {11173245},
keywords = {Animals, Disease Outbreaks/history/*veterinary, Genetic Predisposition to Disease, History, 18th Century, History, 19th Century, History, 20th Century, Scrapie/epidemiology/genetics/*history, Sheep, United Kingdom/epidemiology},
pages = {67--70}
}
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