Exposure, infection and immune responses to Schistosoma haematobium in young children. Woolhouse, M. E., Mutapi, F., Ndhlovu, P. D., Chandiwana, S. K., & Hagan, P. Parasitology, 120 ( Pt 1):37--44, January, 2000. abstract bibtex Behavioural, parasitological and immunological data were obtained from 48 children up to 6 years old, resident in a Schistosoma haematobium endemic area in Zimbabwe. The children averaged more than 1 contact with infective water bodies every 3 days and all showed immunological evidence of exposure (an anti-cercarial and/or anti-egg antibody response). IgM was the dominant isotype and appeared in the youngest children, followed by IgA, IgE and IgG3. However, only 38 children showed evidence of infection (an anti-egg response or eggs in urine) and only 14 were excreting eggs. The best estimates from these data are that less than 1 in 100 contacts results in infection and less than 1 in 1000 result in egg output. This suggests that there may be substantial attrition of invading cercaria even in naive individuals.
@article{woolhouse_exposure_2000,
title = {Exposure, infection and immune responses to {Schistosoma} haematobium in young children.},
volume = {120 ( Pt 1)},
issn = {0031-1820 0031-1820},
abstract = {Behavioural, parasitological and immunological data were obtained from 48 children up to 6 years old, resident in a Schistosoma haematobium endemic area in Zimbabwe. The children averaged more than 1 contact with infective water bodies every 3 days and all showed immunological evidence of exposure (an anti-cercarial and/or anti-egg antibody response). IgM was the dominant isotype and appeared in the youngest children, followed by IgA, IgE and IgG3. However, only 38 children showed evidence of infection (an anti-egg response or eggs in urine) and only 14 were excreting eggs. The best estimates from these data are that less than 1 in 100 contacts results in infection and less than 1 in 1000 result in egg output. This suggests that there may be substantial attrition of invading cercaria even in naive individuals.},
language = {eng},
journal = {Parasitology},
author = {Woolhouse, M. E. and Mutapi, F. and Ndhlovu, P. D. and Chandiwana, S. K. and Hagan, P.},
month = jan,
year = {2000},
pmid = {10726264},
keywords = {Animals, Anthelmintics/therapeutic use, Antibodies, Helminth/*blood, Antibodies, Monoclonal, Antigens, Helminth/blood, Child, Preschool, Enzyme-Linked Immunosorbent Assay, Feces/parasitology, Humans, Immunoglobulins/blood, Infant, Likelihood Functions, Models, Biological, Parasite Egg Count, Praziquantel/therapeutic use, Prevalence, Schistosoma haematobium/*immunology, Schistosomiasis haematobia/blood/epidemiology/*immunology/urine, Water/*parasitology, Zimbabwe/epidemiology},
pages = {37--44}
}
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