Population choice in mapping genes for complex diseases. Wright, A., F., Carothers, A., D., & Pirastu, M. Nat Genet, 23(4):397-404., 1999. Paper Website abstract bibtex The difficulty of identifying susceptibility genes for common diseases has polarized geneticists' views on what disease models are appropriate and how best to proceed once high-density genome maps become available. Different disease models have different implications for using linkage or linkage-disequilibrium-based approaches for mapping complex disease genes. We argue that the choice of study population is a critical factor when designing a study, and that genetically simplified isolates are more useful than diverse continental populations under most assumptions.
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pages = {397-404.},
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abstract = {The difficulty of identifying susceptibility genes for common diseases has polarized geneticists' views on what disease models are appropriate and how best to proceed once high-density genome maps become available. Different disease models have different implications for using linkage or linkage-disequilibrium-based approaches for mapping complex disease genes. We argue that the choice of study population is a critical factor when designing a study, and that genetically simplified isolates are more useful than diverse continental populations under most assumptions.},
bibtype = {article},
author = {Wright, A F and Carothers, A D and Pirastu, M},
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