@article{wu_carotenoid_2020,
	title = {Carotenoid {Intake} and {Circulating} {Carotenoids} {Are} {Inversely} {Associated} with the {Risk} of {Bladder} {Cancer}: {A} {Dose}-{Response} {Meta}-analysis},
	volume = {11},
	issn = {2156-5376},
	shorttitle = {Carotenoid {Intake} and {Circulating} {Carotenoids} {Are} {Inversely} {Associated} with the {Risk} of {Bladder} {Cancer}},
	doi = {10.1093/advances/nmz120},
	abstract = {Some evidence indicates that carotenoids may reduce the risk of bladder cancer (BC), but the association is unclear. We conducted a systematic review and meta-analysis of case-control and cohort studies investigating the relation between carotenoid intake or circulating carotenoid concentrations and BC risk in men and women. All relevant epidemiologic studies were identified by a search of PubMed and Scopus databases, and the Cochrane Library from inception to April 2019 with no restrictions. A random-effects model was used to calculate pooled RRs and their 95\% CIs across studies for high compared with low categories of intake or circulating concentrations. We also performed a dose-response meta-analysis using the Greenland and Longnecker method and random-effects models. A total of 22 studies involving 516,740 adults were included in the meta-analysis. The pooled RRs of BC for the highest compared with the lowest category of carotenoid intake and circulating carotenoid concentrations were 0.88 (95\% CI: 0.76, 1.03) and 0.36 (95\% CI: 0.12, 1.07), respectively. The pooled RR of BC for the highest compared with lowest circulating lutein and zeaxanthin concentrations was 0.53 (95\% CI: 0.33, 0.84). Dose-response analysis showed that BC risk decreased by 42\% for every 1 mg increase in daily dietary β-cryptoxanthin intake (RR: 0.58; 95\% CI: 0.36, 0.94); by 76\% for every 1 μmol/L increase in circulating concentration of α-carotene (RR: 0.24; 95\% CI: 0.08, 0.67); by 27\% for every 1 μmol/L increase in circulating concentration of β-carotene (RR: 0.73; 95\% CI: 0.57, 0.94); and by 56\% for every 1 μmol/L increase in circulating concentrations of lutein and zeaxanthin (RR: 0.44; 95\% CI: 0.28, 0.67). Dietary β-cryptoxanthin intake and circulating concentrations of α-carotene, β-carotene, and lutein and zeaxanthin were inversely associated with BC risk. The protocol was registered at PROSPERO as CRD42019133240.},
	language = {eng},
	number = {3},
	journal = {Advances in Nutrition (Bethesda, Md.)},
	author = {Wu, Shenghui and Liu, Yanning and Michalek, Joel E. and Mesa, Ruben A. and Parma, Dorothy Long and Rodriguez, Ronald and Mansour, Ahmed M. and Svatek, Robert and Tucker, Thomas C. and Ramirez, Amelie G.},
	month = may,
	year = {2020},
	pmid = {31800007},
	pmcid = {PMC7231589},
	keywords = {Adult, Carotenoids, Female, Humans, Lutein, Male, Urinary Bladder Neoplasms, Zeaxanthins, beta Carotene, bladder cancer, blood, carotenoids, diet, lutein, lycopene, zeaxanthin, α-carotene, β-carotene, β-cryptoxanthin},
	pages = {630--643},
}

{"_id":"2daxBm69cEnpBn2aM","bibbaseid":"wu-liu-michalek-mesa-parma-rodriguez-mansour-svatek-etal-carotenoidintakeandcirculatingcarotenoidsareinverselyassociatedwiththeriskofbladdercanceradoseresponsemetaanalysis-2020","author_short":["Wu, S.","Liu, Y.","Michalek, J. E.","Mesa, R. A.","Parma, D. L.","Rodriguez, R.","Mansour, A. M.","Svatek, R.","Tucker, T. C.","Ramirez, A. G."],"bibdata":{"bibtype":"article","type":"article","title":"Carotenoid Intake and Circulating Carotenoids Are Inversely Associated with the Risk of Bladder Cancer: A Dose-Response Meta-analysis","volume":"11","issn":"2156-5376","shorttitle":"Carotenoid Intake and Circulating Carotenoids Are Inversely Associated with the Risk of Bladder Cancer","doi":"10.1093/advances/nmz120","abstract":"Some evidence indicates that carotenoids may reduce the risk of bladder cancer (BC), but the association is unclear. We conducted a systematic review and meta-analysis of case-control and cohort studies investigating the relation between carotenoid intake or circulating carotenoid concentrations and BC risk in men and women. All relevant epidemiologic studies were identified by a search of PubMed and Scopus databases, and the Cochrane Library from inception to April 2019 with no restrictions. A random-effects model was used to calculate pooled RRs and their 95% CIs across studies for high compared with low categories of intake or circulating concentrations. We also performed a dose-response meta-analysis using the Greenland and Longnecker method and random-effects models. A total of 22 studies involving 516,740 adults were included in the meta-analysis. The pooled RRs of BC for the highest compared with the lowest category of carotenoid intake and circulating carotenoid concentrations were 0.88 (95% CI: 0.76, 1.03) and 0.36 (95% CI: 0.12, 1.07), respectively. The pooled RR of BC for the highest compared with lowest circulating lutein and zeaxanthin concentrations was 0.53 (95% CI: 0.33, 0.84). Dose-response analysis showed that BC risk decreased by 42% for every 1 mg increase in daily dietary β-cryptoxanthin intake (RR: 0.58; 95% CI: 0.36, 0.94); by 76% for every 1 μmol/L increase in circulating concentration of α-carotene (RR: 0.24; 95% CI: 0.08, 0.67); by 27% for every 1 μmol/L increase in circulating concentration of β-carotene (RR: 0.73; 95% CI: 0.57, 0.94); and by 56% for every 1 μmol/L increase in circulating concentrations of lutein and zeaxanthin (RR: 0.44; 95% CI: 0.28, 0.67). Dietary β-cryptoxanthin intake and circulating concentrations of α-carotene, β-carotene, and lutein and zeaxanthin were inversely associated with BC risk. The protocol was registered at PROSPERO as CRD42019133240.","language":"eng","number":"3","journal":"Advances in Nutrition (Bethesda, Md.)","author":[{"propositions":[],"lastnames":["Wu"],"firstnames":["Shenghui"],"suffixes":[]},{"propositions":[],"lastnames":["Liu"],"firstnames":["Yanning"],"suffixes":[]},{"propositions":[],"lastnames":["Michalek"],"firstnames":["Joel","E."],"suffixes":[]},{"propositions":[],"lastnames":["Mesa"],"firstnames":["Ruben","A."],"suffixes":[]},{"propositions":[],"lastnames":["Parma"],"firstnames":["Dorothy","Long"],"suffixes":[]},{"propositions":[],"lastnames":["Rodriguez"],"firstnames":["Ronald"],"suffixes":[]},{"propositions":[],"lastnames":["Mansour"],"firstnames":["Ahmed","M."],"suffixes":[]},{"propositions":[],"lastnames":["Svatek"],"firstnames":["Robert"],"suffixes":[]},{"propositions":[],"lastnames":["Tucker"],"firstnames":["Thomas","C."],"suffixes":[]},{"propositions":[],"lastnames":["Ramirez"],"firstnames":["Amelie","G."],"suffixes":[]}],"month":"May","year":"2020","pmid":"31800007","pmcid":"PMC7231589","keywords":"Adult, Carotenoids, Female, Humans, Lutein, Male, Urinary Bladder Neoplasms, Zeaxanthins, beta Carotene, bladder cancer, blood, carotenoids, diet, lutein, lycopene, zeaxanthin, α-carotene, β-carotene, β-cryptoxanthin","pages":"630–643","bibtex":"@article{wu_carotenoid_2020,\n\ttitle = {Carotenoid {Intake} and {Circulating} {Carotenoids} {Are} {Inversely} {Associated} with the {Risk} of {Bladder} {Cancer}: {A} {Dose}-{Response} {Meta}-analysis},\n\tvolume = {11},\n\tissn = {2156-5376},\n\tshorttitle = {Carotenoid {Intake} and {Circulating} {Carotenoids} {Are} {Inversely} {Associated} with the {Risk} of {Bladder} {Cancer}},\n\tdoi = {10.1093/advances/nmz120},\n\tabstract = {Some evidence indicates that carotenoids may reduce the risk of bladder cancer (BC), but the association is unclear. We conducted a systematic review and meta-analysis of case-control and cohort studies investigating the relation between carotenoid intake or circulating carotenoid concentrations and BC risk in men and women. All relevant epidemiologic studies were identified by a search of PubMed and Scopus databases, and the Cochrane Library from inception to April 2019 with no restrictions. A random-effects model was used to calculate pooled RRs and their 95\\% CIs across studies for high compared with low categories of intake or circulating concentrations. We also performed a dose-response meta-analysis using the Greenland and Longnecker method and random-effects models. A total of 22 studies involving 516,740 adults were included in the meta-analysis. The pooled RRs of BC for the highest compared with the lowest category of carotenoid intake and circulating carotenoid concentrations were 0.88 (95\\% CI: 0.76, 1.03) and 0.36 (95\\% CI: 0.12, 1.07), respectively. The pooled RR of BC for the highest compared with lowest circulating lutein and zeaxanthin concentrations was 0.53 (95\\% CI: 0.33, 0.84). Dose-response analysis showed that BC risk decreased by 42\\% for every 1 mg increase in daily dietary β-cryptoxanthin intake (RR: 0.58; 95\\% CI: 0.36, 0.94); by 76\\% for every 1 μmol/L increase in circulating concentration of α-carotene (RR: 0.24; 95\\% CI: 0.08, 0.67); by 27\\% for every 1 μmol/L increase in circulating concentration of β-carotene (RR: 0.73; 95\\% CI: 0.57, 0.94); and by 56\\% for every 1 μmol/L increase in circulating concentrations of lutein and zeaxanthin (RR: 0.44; 95\\% CI: 0.28, 0.67). Dietary β-cryptoxanthin intake and circulating concentrations of α-carotene, β-carotene, and lutein and zeaxanthin were inversely associated with BC risk. The protocol was registered at PROSPERO as CRD42019133240.},\n\tlanguage = {eng},\n\tnumber = {3},\n\tjournal = {Advances in Nutrition (Bethesda, Md.)},\n\tauthor = {Wu, Shenghui and Liu, Yanning and Michalek, Joel E. and Mesa, Ruben A. and Parma, Dorothy Long and Rodriguez, Ronald and Mansour, Ahmed M. and Svatek, Robert and Tucker, Thomas C. and Ramirez, Amelie G.},\n\tmonth = may,\n\tyear = {2020},\n\tpmid = {31800007},\n\tpmcid = {PMC7231589},\n\tkeywords = {Adult, Carotenoids, Female, Humans, Lutein, Male, Urinary Bladder Neoplasms, Zeaxanthins, beta Carotene, bladder cancer, blood, carotenoids, diet, lutein, lycopene, zeaxanthin, α-carotene, β-carotene, β-cryptoxanthin},\n\tpages = {630--643},\n}\n\n","author_short":["Wu, S.","Liu, Y.","Michalek, J. E.","Mesa, R. A.","Parma, D. L.","Rodriguez, R.","Mansour, A. M.","Svatek, R.","Tucker, T. C.","Ramirez, A. G."],"key":"wu_carotenoid_2020","id":"wu_carotenoid_2020","bibbaseid":"wu-liu-michalek-mesa-parma-rodriguez-mansour-svatek-etal-carotenoidintakeandcirculatingcarotenoidsareinverselyassociatedwiththeriskofbladdercanceradoseresponsemetaanalysis-2020","role":"author","urls":{},"keyword":["Adult","Carotenoids","Female","Humans","Lutein","Male","Urinary Bladder Neoplasms","Zeaxanthins","beta Carotene","bladder cancer","blood","carotenoids","diet","lutein","lycopene","zeaxanthin","α-carotene","β-carotene","β-cryptoxanthin"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://api.zotero.org/users/585595/collections/AHTPD767/items?key=KhA4GoMeOvxPn5tlpemkMrP3&format=bibtex&limit=100","dataSources":["DfcenonoS4CcJtLNQ"],"keywords":["adult","carotenoids","female","humans","lutein","male","urinary bladder neoplasms","zeaxanthins","beta carotene","bladder cancer","blood","carotenoids","diet","lutein","lycopene","zeaxanthin","α-carotene","β-carotene","β-cryptoxanthin"],"search_terms":["carotenoid","intake","circulating","carotenoids","inversely","associated","risk","bladder","cancer","dose","response","meta","analysis","wu","liu","michalek","mesa","parma","rodriguez","mansour","svatek","tucker","ramirez"],"title":"Carotenoid Intake and Circulating Carotenoids Are Inversely Associated with the Risk of Bladder Cancer: A Dose-Response Meta-analysis","year":2020}