A movable long-term implantable soft microfibre for dynamic bioelectronics. Xie, R., Han, F., Yu, Q., Li, D., Han, X., Xu, X., Yu, H., Huang, J., Zhou, X., Zhao, H., Deng, X., Tian, Q., Li, Q., Li, H., Zhao, Y., Ma, G., Li, G., Zheng, H., Zhu, M., Yan, W., Xu, T., & Liu, Z. Nature, 645(8081):648–655, September, 2025. Publisher: Nature Publishing Group![A movable long-term implantable soft microfibre for dynamic bioelectronics [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Long-term implantable bioelectronics offer a powerful means to evaluate the function of the nervous system and serve as effective human–machine interfaces1–3. Here, inspired by earthworms, we introduce NeuroWorm—a soft, stretchable and movable fibre sensor designed for bioelectronic interface. Our approach involves rolling to transform 2D bioelectronic devices into 1D NeuroWorm, creating a multifunctional microfibre that houses longitudinally distributed electrode arrays for both bioelectrical and biomechanical monitoring. NeuroWorm effectively records high-quality spatio-temporal signals in situ while steerably advancing within the brain or on the muscle as needed. This allows for the dynamic targeting and shifting of desired monitoring sites. Implanted in muscle through a tiny incision, NeuroWorm provides stable bioelectrical monitoring in rats for more than 43 weeks. Even after 54 weeks of implantation in muscle, fibroblast encapsulation around the fibre remains negligible. Our NeuroWorm represents a platform that promotes a substantial advance in bioelectronics—from an immobile probe fixed in place to active, intelligent and living devices for long-term, minimally invasive and mobile evaluation of the nervous system.
@article{xie_movable_2025,
title = {A movable long-term implantable soft microfibre for dynamic bioelectronics},
volume = {645},
copyright = {2025 The Author(s), under exclusive licence to Springer Nature Limited},
issn = {1476-4687},
url = {https://www.nature.com/articles/s41586-025-09344-w},
doi = {10.1038/s41586-025-09344-w},
abstract = {Long-term implantable bioelectronics offer a powerful means to evaluate the function of the nervous system and serve as effective human–machine interfaces1–3. Here, inspired by earthworms, we introduce NeuroWorm—a soft, stretchable and movable fibre sensor designed for bioelectronic interface. Our approach involves rolling to transform 2D bioelectronic devices into 1D NeuroWorm, creating a multifunctional microfibre that houses longitudinally distributed electrode arrays for both bioelectrical and biomechanical monitoring. NeuroWorm effectively records high-quality spatio-temporal signals in situ while steerably advancing within the brain or on the muscle as needed. This allows for the dynamic targeting and shifting of desired monitoring sites. Implanted in muscle through a tiny incision, NeuroWorm provides stable bioelectrical monitoring in rats for more than 43 weeks. Even after 54 weeks of implantation in muscle, fibroblast encapsulation around the fibre remains negligible. Our NeuroWorm represents a platform that promotes a substantial advance in bioelectronics—from an immobile probe fixed in place to active, intelligent and living devices for long-term, minimally invasive and mobile evaluation of the nervous system.},
language = {en},
number = {8081},
urldate = {2025-11-07},
journal = {Nature},
author = {Xie, Ruijie and Han, Fei and Yu, Qianhengyuan and Li, Dong and Han, Xu and Xu, Xiaolong and Yu, Huan and Huang, Jianping and Zhou, Xiaomeng and Zhao, Hang and Deng, Xinping and Tian, Qiong and Li, Qingsong and Li, Hanfei and Zhao, Yang and Ma, Guoyao and Li, Guanglin and Zheng, Hairong and Zhu, Meifang and Yan, Wei and Xu, Tiantian and Liu, Zhiyuan},
month = sep,
year = {2025},
note = {Publisher: Nature Publishing Group},
keywords = {Biomedical engineering, Sensors and biosensors},
pages = {648--655},
}
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