Should diabetic ketosis without acidosis be included in ketosis-prone type 2 diabetes mellitus?. Xie, X., Hu, Y., Cheng, C., Feng, T., He, K., & Mao, X. Diabetes/Metabolism Research and Reviews, 30(1):54–59, 2014. 00000![Should diabetic ketosis without acidosis be included in ketosis-prone type 2 diabetes mellitus? [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Background The incidence of ketosis-prone type 2 diabetes is very low except for people of sub-Saharan African origin and African Americans. However, there also are some type 2 diabetes patients with diabetic ketosis without acidosis (DKWA). We question whether DKWA should be included as a subtype of ketosis-prone type 2 diabetes mellitus and compared the clinical characteristics of DKWA and diabetic ketoacidosis (DKA) patients. Methods The study population consisted of 594 consecutive unrelated Chinese inpatients with newly diagnosed type 2 diabetes. Demographic and clinical characteristics (age, gender, family history of diabetes, body mass index, blood pressure and plasma lipid parameters) were recorded. The patients were divided into ketosis-resistant diabetes (KRD), DKWA and DKA groups on the basis of urinary ketones, blood pH and bicarbonate levels. The blood glucose and c-peptide levels of the patients were also evaluated. Results The prevalence of KRD, DKWA and DKA were 78.33%, 19.72% and 1.95%, respectively, in the study population. The clinical characteristics of patients with DKWA group patients were similar to those with DKA, except that DKA patients had higher blood glucose and deteriorated β cell function. Conclusions Diabetic ketosis without acidosis and DKA patients share similar clinical characteristics; DKWA should be considered ketosis-prone type 2 diabetes. Therefore, the prevalence of ketosis-prone type 2 diabetes might be underestimated. Copyright © 2013 John Wiley & Sons, Ltd.
@article{xie_should_2014,
title = {Should diabetic ketosis without acidosis be included in ketosis-prone type 2 diabetes mellitus?},
volume = {30},
issn = {1520-7560},
url = {http://onlinelibrary.wiley.com/doi/abs/10.1002/dmrr.2448},
doi = {10.1002/dmrr.2448},
abstract = {Background The incidence of ketosis-prone type 2 diabetes is very low except for people of sub-Saharan African origin and African Americans. However, there also are some type 2 diabetes patients with diabetic ketosis without acidosis (DKWA). We question whether DKWA should be included as a subtype of ketosis-prone type 2 diabetes mellitus and compared the clinical characteristics of DKWA and diabetic ketoacidosis (DKA) patients. Methods The study population consisted of 594 consecutive unrelated Chinese inpatients with newly diagnosed type 2 diabetes. Demographic and clinical characteristics (age, gender, family history of diabetes, body mass index, blood pressure and plasma lipid parameters) were recorded. The patients were divided into ketosis-resistant diabetes (KRD), DKWA and DKA groups on the basis of urinary ketones, blood pH and bicarbonate levels. The blood glucose and c-peptide levels of the patients were also evaluated. Results The prevalence of KRD, DKWA and DKA were 78.33\%, 19.72\% and 1.95\%, respectively, in the study population. The clinical characteristics of patients with DKWA group patients were similar to those with DKA, except that DKA patients had higher blood glucose and deteriorated β cell function. Conclusions Diabetic ketosis without acidosis and DKA patients share similar clinical characteristics; DKWA should be considered ketosis-prone type 2 diabetes. Therefore, the prevalence of ketosis-prone type 2 diabetes might be underestimated. Copyright © 2013 John Wiley \& Sons, Ltd.},
language = {en},
number = {1},
urldate = {2019-06-02},
journal = {Diabetes/Metabolism Research and Reviews},
author = {Xie, Xiao-Jing and Hu, Yun and Cheng, Cheng and Feng, Tian-Tian and He, Ke and Mao, Xiao-Ming},
year = {2014},
note = {00000},
keywords = {clinical characteristics, diabetic ketosis without acidosis, ketosis-prone type 2 diabetes, prevalence},
pages = {54--59}
}
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Methods The study population consisted of 594 consecutive unrelated Chinese inpatients with newly diagnosed type 2 diabetes. Demographic and clinical characteristics (age, gender, family history of diabetes, body mass index, blood pressure and plasma lipid parameters) were recorded. The patients were divided into ketosis-resistant diabetes (KRD), DKWA and DKA groups on the basis of urinary ketones, blood pH and bicarbonate levels. The blood glucose and c-peptide levels of the patients were also evaluated. Results The prevalence of KRD, DKWA and DKA were 78.33%, 19.72% and 1.95%, respectively, in the study population. The clinical characteristics of patients with DKWA group patients were similar to those with DKA, except that DKA patients had higher blood glucose and deteriorated β cell function. Conclusions Diabetic ketosis without acidosis and DKA patients share similar clinical characteristics; DKWA should be considered ketosis-prone type 2 diabetes. Therefore, the prevalence of ketosis-prone type 2 diabetes might be underestimated. Copyright © 2013 John Wiley & Sons, Ltd.","language":"en","number":"1","urldate":"2019-06-02","journal":"Diabetes/Metabolism Research and Reviews","author":[{"propositions":[],"lastnames":["Xie"],"firstnames":["Xiao-Jing"],"suffixes":[]},{"propositions":[],"lastnames":["Hu"],"firstnames":["Yun"],"suffixes":[]},{"propositions":[],"lastnames":["Cheng"],"firstnames":["Cheng"],"suffixes":[]},{"propositions":[],"lastnames":["Feng"],"firstnames":["Tian-Tian"],"suffixes":[]},{"propositions":[],"lastnames":["He"],"firstnames":["Ke"],"suffixes":[]},{"propositions":[],"lastnames":["Mao"],"firstnames":["Xiao-Ming"],"suffixes":[]}],"year":"2014","note":"00000","keywords":"clinical characteristics, diabetic ketosis without acidosis, ketosis-prone type 2 diabetes, prevalence","pages":"54–59","bibtex":"@article{xie_should_2014,\n\ttitle = {Should diabetic ketosis without acidosis be included in ketosis-prone type 2 diabetes mellitus?},\n\tvolume = {30},\n\tissn = {1520-7560},\n\turl = {http://onlinelibrary.wiley.com/doi/abs/10.1002/dmrr.2448},\n\tdoi = {10.1002/dmrr.2448},\n\tabstract = {Background The incidence of ketosis-prone type 2 diabetes is very low except for people of sub-Saharan African origin and African Americans. However, there also are some type 2 diabetes patients with diabetic ketosis without acidosis (DKWA). We question whether DKWA should be included as a subtype of ketosis-prone type 2 diabetes mellitus and compared the clinical characteristics of DKWA and diabetic ketoacidosis (DKA) patients. Methods The study population consisted of 594 consecutive unrelated Chinese inpatients with newly diagnosed type 2 diabetes. Demographic and clinical characteristics (age, gender, family history of diabetes, body mass index, blood pressure and plasma lipid parameters) were recorded. The patients were divided into ketosis-resistant diabetes (KRD), DKWA and DKA groups on the basis of urinary ketones, blood pH and bicarbonate levels. The blood glucose and c-peptide levels of the patients were also evaluated. Results The prevalence of KRD, DKWA and DKA were 78.33\\%, 19.72\\% and 1.95\\%, respectively, in the study population. The clinical characteristics of patients with DKWA group patients were similar to those with DKA, except that DKA patients had higher blood glucose and deteriorated β cell function. Conclusions Diabetic ketosis without acidosis and DKA patients share similar clinical characteristics; DKWA should be considered ketosis-prone type 2 diabetes. Therefore, the prevalence of ketosis-prone type 2 diabetes might be underestimated. 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