Neocortical somatostatin-expressing GABAergic interneurons disinhibit the thalamorecipient layer 4. Xu, H., Jeong, H., Tremblay, R., & Rudy, B. Neuron, 77:155–167, 2013. doi abstract bibtex Subtypes of GABAergic interneurons (INs) are crucial for cortical function, yet their specific roles are largely unknown. In contrast to supra- and infragranular layers, where most somatostatin-expressing (SOM) INs are layer 1-targeting Martinotti cells, the axons of SOM INs in layer 4 of somatosensory cortex largely remain within layer 4. Moreover, we found that whereas layers 2/3 SOM INs target mainly pyramidal cells (PCs), layer 4 SOM INs target mainly fast-spiking (FS) INs. Accordingly, optogenetic inhibition of SOM INs in an active cortical network increases the firing of layers 2/3 PCs whereas it decreases the firing of layer 4 principal neurons (PNs). This unexpected effect of SOM INs on layer 4 PNs occurs via their inhibition of local FS INs. These results reveal a disinhibitory microcircuit in the thalamorecipient layer through interactions among subtypes of INs and suggest that the SOM IN-mediated disinhibition represents an important circuit mechanism for cortical information processing.
@Article{Xu2013,
author = {Xu, Han and Jeong, Hyo-Young and Tremblay, Robin and Rudy, Bernardo},
journal = {Neuron},
title = {Neocortical somatostatin-expressing GABAergic interneurons disinhibit the thalamorecipient layer 4.},
year = {2013},
issn = {1097-4199},
pages = {155--167},
volume = {77},
abstract = {Subtypes of GABAergic interneurons (INs) are crucial for cortical function, yet their specific roles are largely unknown. In contrast to supra- and infragranular layers, where most somatostatin-expressing (SOM) INs are layer 1-targeting Martinotti cells, the axons of SOM INs in layer 4 of somatosensory cortex largely remain within layer 4. Moreover, we found that whereas layers 2/3 SOM INs target mainly pyramidal cells (PCs), layer 4 SOM INs target mainly fast-spiking (FS) INs. Accordingly, optogenetic inhibition of SOM INs in an active cortical network increases the firing of layers 2/3 PCs whereas it decreases the firing of layer 4 principal neurons (PNs). This unexpected effect of SOM INs on layer 4 PNs occurs via their inhibition of local FS INs. These results reveal a disinhibitory microcircuit in the thalamorecipient layer through interactions among subtypes of INs and suggest that the SOM IN-mediated disinhibition represents an important circuit mechanism for cortical information processing.},
chemicals = {Somatostatin},
citation-subset = {IM},
completed = {2013-03-05},
country = {United States},
created = {2013-01-14},
doi = {10.1016/j.neuron.2012.11.004},
issn-linking = {0896-6273},
issue = {1},
keywords = {Action Potentials, physiology; Animals; Animals, Newborn; GABAergic Neurons, physiology; Gene Expression Regulation; Interneurons, metabolism; Mice; Mice, Transgenic; Neocortex, cytology, metabolism; Neural Inhibition, genetics; Somatostatin, biosynthesis, genetics; Thalamus, metabolism},
mid = {NIHMS431792},
nlm = {PMC3556168},
nlm-id = {8809320},
pmc = {PMC3556168},
pmid = {23312523},
pubmodel = {Print},
revised = {2016-10-19},
}
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