@Article{Xu2013,
  author          = {Xu, Han and Jeong, Hyo-Young and Tremblay, Robin and Rudy, Bernardo},
  journal         = {Neuron},
  title           = {Neocortical somatostatin-expressing GABAergic interneurons disinhibit the thalamorecipient layer 4.},
  year            = {2013},
  issn            = {1097-4199},
  pages           = {155--167},
  volume          = {77},
  abstract        = {Subtypes of GABAergic interneurons (INs) are crucial for cortical function, yet their specific roles are largely unknown. In contrast to supra- and infragranular layers, where most somatostatin-expressing (SOM) INs are layer 1-targeting Martinotti cells, the axons of SOM INs in layer 4 of somatosensory cortex largely remain within layer 4. Moreover, we found that whereas layers 2/3 SOM INs target mainly pyramidal cells (PCs), layer 4 SOM INs target mainly fast-spiking (FS) INs. Accordingly, optogenetic inhibition of SOM INs in an active cortical network increases the firing of layers 2/3 PCs whereas it decreases the firing of layer 4 principal neurons (PNs). This unexpected effect of SOM INs on layer 4 PNs occurs via their inhibition of local FS INs. These results reveal a disinhibitory microcircuit in the thalamorecipient layer through interactions among subtypes of INs and suggest that the SOM IN-mediated disinhibition represents an important circuit mechanism for cortical information processing.},
  chemicals       = {Somatostatin},
  citation-subset = {IM},
  completed       = {2013-03-05},
  country         = {United States},
  created         = {2013-01-14},
  doi             = {10.1016/j.neuron.2012.11.004},
  issn-linking    = {0896-6273},
  issue           = {1},
  keywords        = {Action Potentials, physiology; Animals; Animals, Newborn; GABAergic Neurons, physiology; Gene Expression Regulation; Interneurons, metabolism; Mice; Mice, Transgenic; Neocortex, cytology, metabolism; Neural Inhibition, genetics; Somatostatin, biosynthesis, genetics; Thalamus, metabolism},
  mid             = {NIHMS431792},
  nlm             = {PMC3556168},
  nlm-id          = {8809320},
  pmc             = {PMC3556168},
  pmid            = {23312523},
  pubmodel        = {Print},
  revised         = {2016-10-19},
}

{"_id":"gkvkETJLTNxwFNMXp","bibbaseid":"xu-jeong-tremblay-rudy-neocorticalsomatostatinexpressinggabaergicinterneuronsdisinhibitthethalamorecipientlayer4-2013","author_short":["Xu, H.","Jeong, H.","Tremblay, R.","Rudy, B."],"bibdata":{"bibtype":"article","type":"article","author":[{"propositions":[],"lastnames":["Xu"],"firstnames":["Han"],"suffixes":[]},{"propositions":[],"lastnames":["Jeong"],"firstnames":["Hyo-Young"],"suffixes":[]},{"propositions":[],"lastnames":["Tremblay"],"firstnames":["Robin"],"suffixes":[]},{"propositions":[],"lastnames":["Rudy"],"firstnames":["Bernardo"],"suffixes":[]}],"journal":"Neuron","title":"Neocortical somatostatin-expressing GABAergic interneurons disinhibit the thalamorecipient layer 4.","year":"2013","issn":"1097-4199","pages":"155–167","volume":"77","abstract":"Subtypes of GABAergic interneurons (INs) are crucial for cortical function, yet their specific roles are largely unknown. In contrast to supra- and infragranular layers, where most somatostatin-expressing (SOM) INs are layer 1-targeting Martinotti cells, the axons of SOM INs in layer 4 of somatosensory cortex largely remain within layer 4. Moreover, we found that whereas layers 2/3 SOM INs target mainly pyramidal cells (PCs), layer 4 SOM INs target mainly fast-spiking (FS) INs. Accordingly, optogenetic inhibition of SOM INs in an active cortical network increases the firing of layers 2/3 PCs whereas it decreases the firing of layer 4 principal neurons (PNs). This unexpected effect of SOM INs on layer 4 PNs occurs via their inhibition of local FS INs. These results reveal a disinhibitory microcircuit in the thalamorecipient layer through interactions among subtypes of INs and suggest that the SOM IN-mediated disinhibition represents an important circuit mechanism for cortical information processing.","chemicals":"Somatostatin","citation-subset":"IM","completed":"2013-03-05","country":"United States","created":"2013-01-14","doi":"10.1016/j.neuron.2012.11.004","issn-linking":"0896-6273","issue":"1","keywords":"Action Potentials, physiology; Animals; Animals, Newborn; GABAergic Neurons, physiology; Gene Expression Regulation; Interneurons, metabolism; Mice; Mice, Transgenic; Neocortex, cytology, metabolism; Neural Inhibition, genetics; Somatostatin, biosynthesis, genetics; Thalamus, metabolism","mid":"NIHMS431792","nlm":"PMC3556168","nlm-id":"8809320","pmc":"PMC3556168","pmid":"23312523","pubmodel":"Print","revised":"2016-10-19","bibtex":"@Article{Xu2013,\n author = {Xu, Han and Jeong, Hyo-Young and Tremblay, Robin and Rudy, Bernardo},\n journal = {Neuron},\n title = {Neocortical somatostatin-expressing GABAergic interneurons disinhibit the thalamorecipient layer 4.},\n year = {2013},\n issn = {1097-4199},\n pages = {155--167},\n volume = {77},\n abstract = {Subtypes of GABAergic interneurons (INs) are crucial for cortical function, yet their specific roles are largely unknown. In contrast to supra- and infragranular layers, where most somatostatin-expressing (SOM) INs are layer 1-targeting Martinotti cells, the axons of SOM INs in layer 4 of somatosensory cortex largely remain within layer 4. Moreover, we found that whereas layers 2/3 SOM INs target mainly pyramidal cells (PCs), layer 4 SOM INs target mainly fast-spiking (FS) INs. Accordingly, optogenetic inhibition of SOM INs in an active cortical network increases the firing of layers 2/3 PCs whereas it decreases the firing of layer 4 principal neurons (PNs). This unexpected effect of SOM INs on layer 4 PNs occurs via their inhibition of local FS INs. These results reveal a disinhibitory microcircuit in the thalamorecipient layer through interactions among subtypes of INs and suggest that the SOM IN-mediated disinhibition represents an important circuit mechanism for cortical information processing.},\n chemicals = {Somatostatin},\n citation-subset = {IM},\n completed = {2013-03-05},\n country = {United States},\n created = {2013-01-14},\n doi = {10.1016/j.neuron.2012.11.004},\n issn-linking = {0896-6273},\n issue = {1},\n keywords = {Action Potentials, physiology; Animals; Animals, Newborn; GABAergic Neurons, physiology; Gene Expression Regulation; Interneurons, metabolism; Mice; Mice, Transgenic; Neocortex, cytology, metabolism; Neural Inhibition, genetics; Somatostatin, biosynthesis, genetics; Thalamus, metabolism},\n mid = {NIHMS431792},\n nlm = {PMC3556168},\n nlm-id = {8809320},\n pmc = {PMC3556168},\n pmid = {23312523},\n pubmodel = {Print},\n revised = {2016-10-19},\n}\n\n","author_short":["Xu, H.","Jeong, H.","Tremblay, R.","Rudy, B."],"key":"Xu2013","id":"Xu2013","bibbaseid":"xu-jeong-tremblay-rudy-neocorticalsomatostatinexpressinggabaergicinterneuronsdisinhibitthethalamorecipientlayer4-2013","role":"author","urls":{},"keyword":["Action Potentials","physiology; Animals; Animals","Newborn; GABAergic Neurons","physiology; Gene Expression Regulation; Interneurons","metabolism; Mice; Mice","Transgenic; Neocortex","cytology","metabolism; Neural Inhibition","genetics; Somatostatin","biosynthesis","genetics; Thalamus","metabolism"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://endress.org/publications/ansgar.bib","dataSources":["xPGxHAeh3vZpx4yyE","TXa55dQbNoWnaGmMq"],"keywords":["action potentials","physiology; animals; animals","newborn; gabaergic neurons","physiology; gene expression regulation; interneurons","metabolism; mice; mice","transgenic; neocortex","cytology","metabolism; neural inhibition","genetics; somatostatin","biosynthesis","genetics; thalamus","metabolism"],"search_terms":["neocortical","somatostatin","expressing","gabaergic","interneurons","disinhibit","thalamorecipient","layer","xu","jeong","tremblay","rudy"],"title":"Neocortical somatostatin-expressing GABAergic interneurons disinhibit the thalamorecipient layer 4.","year":2013}