Falsely high HbA1c value due to a novel α1-globin gene mutation: Hb shantou [α127(H10)Lys \textgreater Glu; HBA1: c.382 A \textgreater G]. Xu, A., Lei, J., Li, J., Chen, W., Zhou, Y., Zheng, R., & Ji, L. Scandinavian Journal of Clinical & Laboratory Investigation, 78:621–625, October, 2018. MAG ID: 2899413315
doi  abstract   bibtex   
AbstractHemoglobin A1c (HbA1c) is a widely utilized biomarker for the diagnosis and management of diabetes mellitus. Here, we describe an α1-globin chain hemoglobin variant and investigate its effect on HbA1c measurement. A 26-year-old pregnant woman was suspected to harbor a hemoglobin variant following HbA1c measurement during a routine prenatal examination using D10 (Bio-Rad). An oral glucose tolerance test (OGTT) was performed using an AU5800 clinical chemistry system (Beckman Coulter). HbA1c was reanalyzed using VII-T 2.0 (Bio-Rad), Capillarys 2 Flex Piercing (C2FP, HbA1c program, Sebia), Premier Hb9210 (Trinity Biotech), and Cobas c501 (Cobas Tina-quant Hemoglobin A1c Gen.3). Glycated albumin (GA) level was also quantified using an enzymic method GA Kit (Lucica GA-L, Japan). Hemoglobin analysis was performed using high performance liquid chromatography on the Bio-Rad Variant II (β-thalassemia short program) and capillary electrophoresis (Capillarys 2 Flex Piercing, Hb program). Sanger sequencing of ...
@article{xu_falsely_2018,
	title = {Falsely high {HbA1c} value due to a novel α1-globin gene mutation: {Hb} shantou [α127({H10}){Lys} {\textgreater} {Glu}; {HBA1}: c.382 {A} {\textgreater} {G}].},
	volume = {78},
	doi = {10.1080/00365513.2018.1531298},
	abstract = {AbstractHemoglobin A1c (HbA1c) is a widely utilized biomarker for the diagnosis and management of diabetes mellitus. Here, we describe an α1-globin chain hemoglobin variant and investigate its effect on HbA1c measurement. A 26-year-old pregnant woman was suspected to harbor a hemoglobin variant following HbA1c measurement during a routine prenatal examination using D10 (Bio-Rad). An oral glucose tolerance test (OGTT) was performed using an AU5800 clinical chemistry system (Beckman Coulter). HbA1c was reanalyzed using VII-T 2.0 (Bio-Rad), Capillarys 2 Flex Piercing (C2FP, HbA1c program, Sebia), Premier Hb9210 (Trinity Biotech), and Cobas c501 (Cobas Tina-quant Hemoglobin A1c Gen.3). Glycated albumin (GA) level was also quantified using an enzymic method GA Kit (Lucica GA-L, Japan). Hemoglobin analysis was performed using high performance liquid chromatography on the Bio-Rad Variant II (β-thalassemia short program) and capillary electrophoresis (Capillarys 2 Flex Piercing, Hb program). Sanger sequencing of ...},
	journal = {Scandinavian Journal of Clinical \& Laboratory Investigation},
	author = {Xu, Anping and Lei, Jie and Li, Jie and Chen, Weidong and Zhou, Yu and Zheng, Ruoyang and Ji, Ling},
	month = oct,
	year = {2018},
	doi = {10.1080/00365513.2018.1531298},
	note = {MAG ID: 2899413315},
	pages = {621--625},
}

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