Preparation method of 4-amino-3-quinoline formonitrile derivative. Xu, X. 2013. ![Preparation method of 4-amino-3-quinoline formonitrile derivative [link]](https://bibbase.org/img/filetypes/link.svg "link")
Website abstract bibtex The invention discloses a preparation method of 4-amino-3-quinoline formonitrile derivative. The preparation method comprises the following steps of: condensing and cyclizing 3,4-disubstituted aniline (IIa) and 3,3- dimethoxy-2-formyl propionitrile (IIb) to generate 6,7-disubstituted-3-quinoline formonitrile (III), oxidizing and nitrifying an intermediate (III) to generate 6,7-disubstituted-4-nitryl-3-quinoline formonitrile-N-oxide (IV), and the intermediate (IV) is reduced to generate the 4-amino-3-quinoline formonitrile derivative (I). The 4-amino-3-quinoline formonitrile derivative is an important intermediate for preparation of an anti-tumor medicine with 3-nitrile quinoline parent nucleus structure, and for the preparation method of the 4-amino-3-quinoline formonitrile derivative, raw materials are easy to get, the technology is compact, and the method is economical and environmental-friendly, and is suitable for industrial production.
@misc{
title = {Preparation method of 4-amino-3-quinoline formonitrile derivative},
type = {misc},
year = {2013},
websites = {http://worldwide.espacenet.com/publicationDetails/biblio?DB=EPODOC&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20130828&CC=CN&NR=103265481A&KC=A},
revision = {CN 103265481},
id = {cd13c130-0672-3414-98bd-53444067561e},
created = {2015-12-17T08:57:44.000Z},
file_attached = {false},
profile_id = {a9aa69be-c8c7-3ba9-882f-cb8bc4feafda},
group_id = {e535be7f-8bb5-3cb5-8d9a-aa1013ed86bf},
last_modified = {2015-12-17T08:57:44.000Z},
tags = {acetals_review,beta_acetals},
read = {true},
starred = {false},
authored = {false},
confirmed = {true},
hidden = {false},
citation_key = {Xu2013},
country = {CN},
patent_owner = {Uzhou Mingyue Medical Technology Co., Ltd; Xu, Xuenong},
abstract = {The invention discloses a preparation method of 4-amino-3-quinoline formonitrile derivative. The preparation method comprises the following steps of: condensing and cyclizing 3,4-disubstituted aniline (IIa) and 3,3- dimethoxy-2-formyl propionitrile (IIb) to generate 6,7-disubstituted-3-quinoline formonitrile (III), oxidizing and nitrifying an intermediate (III) to generate 6,7-disubstituted-4-nitryl-3-quinoline formonitrile-N-oxide (IV), and the intermediate (IV) is reduced to generate the 4-amino-3-quinoline formonitrile derivative (I). The 4-amino-3-quinoline formonitrile derivative is an important intermediate for preparation of an anti-tumor medicine with 3-nitrile quinoline parent nucleus structure, and for the preparation method of the 4-amino-3-quinoline formonitrile derivative, raw materials are easy to get, the technology is compact, and the method is economical and environmental-friendly, and is suitable for industrial production.},
bibtype = {misc},
author = {Xu, Xuenong}
}
Downloads: 0
{"_id":"EQcEPGtHx3zgziahg","bibbaseid":"xu-preparationmethodof4amino3quinolineformonitrilederivative-2013","downloads":0,"creationDate":"2015-12-17T09:02:59.952Z","title":"Preparation method of 4-amino-3-quinoline formonitrile derivative","author_short":["Xu, X."],"year":2013,"bibtype":"misc","biburl":null,"bibdata":{"title":"Preparation method of 4-amino-3-quinoline formonitrile derivative","type":"misc","year":"2013","websites":"http://worldwide.espacenet.com/publicationDetails/biblio?DB=EPODOC&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20130828&CC=CN&NR=103265481A&KC=A","revision":"CN 103265481","id":"cd13c130-0672-3414-98bd-53444067561e","created":"2015-12-17T08:57:44.000Z","file_attached":false,"profile_id":"a9aa69be-c8c7-3ba9-882f-cb8bc4feafda","group_id":"e535be7f-8bb5-3cb5-8d9a-aa1013ed86bf","last_modified":"2015-12-17T08:57:44.000Z","tags":"acetals_review,beta_acetals","read":"true","starred":false,"authored":false,"confirmed":"true","hidden":false,"citation_key":"Xu2013","country":"CN","patent_owner":"Uzhou Mingyue Medical Technology Co., Ltd; Xu, Xuenong","abstract":"The invention discloses a preparation method of 4-amino-3-quinoline formonitrile derivative. The preparation method comprises the following steps of: condensing and cyclizing 3,4-disubstituted aniline (IIa) and 3,3- dimethoxy-2-formyl propionitrile (IIb) to generate 6,7-disubstituted-3-quinoline formonitrile (III), oxidizing and nitrifying an intermediate (III) to generate 6,7-disubstituted-4-nitryl-3-quinoline formonitrile-N-oxide (IV), and the intermediate (IV) is reduced to generate the 4-amino-3-quinoline formonitrile derivative (I). The 4-amino-3-quinoline formonitrile derivative is an important intermediate for preparation of an anti-tumor medicine with 3-nitrile quinoline parent nucleus structure, and for the preparation method of the 4-amino-3-quinoline formonitrile derivative, raw materials are easy to get, the technology is compact, and the method is economical and environmental-friendly, and is suitable for industrial production.","bibtype":"misc","author":"Xu, Xuenong","bibtex":"@misc{\n title = {Preparation method of 4-amino-3-quinoline formonitrile derivative},\n type = {misc},\n year = {2013},\n websites = {http://worldwide.espacenet.com/publicationDetails/biblio?DB=EPODOC&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20130828&CC=CN&NR=103265481A&KC=A},\n revision = {CN 103265481},\n id = {cd13c130-0672-3414-98bd-53444067561e},\n created = {2015-12-17T08:57:44.000Z},\n file_attached = {false},\n profile_id = {a9aa69be-c8c7-3ba9-882f-cb8bc4feafda},\n group_id = {e535be7f-8bb5-3cb5-8d9a-aa1013ed86bf},\n last_modified = {2015-12-17T08:57:44.000Z},\n tags = {acetals_review,beta_acetals},\n read = {true},\n starred = {false},\n authored = {false},\n confirmed = {true},\n hidden = {false},\n citation_key = {Xu2013},\n country = {CN},\n patent_owner = {Uzhou Mingyue Medical Technology Co., Ltd; Xu, Xuenong},\n abstract = {The invention discloses a preparation method of 4-amino-3-quinoline formonitrile derivative. The preparation method comprises the following steps of: condensing and cyclizing 3,4-disubstituted aniline (IIa) and 3,3- dimethoxy-2-formyl propionitrile (IIb) to generate 6,7-disubstituted-3-quinoline formonitrile (III), oxidizing and nitrifying an intermediate (III) to generate 6,7-disubstituted-4-nitryl-3-quinoline formonitrile-N-oxide (IV), and the intermediate (IV) is reduced to generate the 4-amino-3-quinoline formonitrile derivative (I). The 4-amino-3-quinoline formonitrile derivative is an important intermediate for preparation of an anti-tumor medicine with 3-nitrile quinoline parent nucleus structure, and for the preparation method of the 4-amino-3-quinoline formonitrile derivative, raw materials are easy to get, the technology is compact, and the method is economical and environmental-friendly, and is suitable for industrial production.},\n bibtype = {misc},\n author = {Xu, Xuenong}\n}","author_short":["Xu, X."],"urls":{"Website":"http://worldwide.espacenet.com/publicationDetails/biblio?DB=EPODOC&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20130828&CC=CN&NR=103265481A&KC=A"},"bibbaseid":"xu-preparationmethodof4amino3quinolineformonitrilederivative-2013","role":"author","downloads":0},"search_terms":["preparation","method","amino","quinoline","formonitrile","derivative","xu"],"keywords":[],"authorIDs":[]}