Risk factors for early miscarriage among Chinese: a hospital-based case-control study. Xu, G., Wu, Y., Yang, L., Yuan, L., Guo, H., Zhang, F., Guan, Y., & Yao, W. Fertility and Sterility, 101(6):1663–1670, June, 2014.
doi  abstract   bibtex   
OBJECTIVE: To investigate the risk factors for early miscarriage among Chinese women. DESIGN: Hospital-based matched case-control study. SETTING: Academic medical center and maternal health hospital. PATIENT(S): 620 women with early miscarriage (less than 13 weeks of gestation) and 1,240 normal pregnant women. INTERVENTION(S): Face-to-face questionnaire. MAIN OUTCOME MEASURE(S): Multivariable conditional odds ratio (OR) and 95% confidence interval (CI) to measure risk factors. RESULT(S): After adjustment for confounding factors, the following were independently associated with increased risk: history of miscarriage, repeated induced abortion, working night shifts, and frequent staying up late. Vitamin supplementation and regular physical activity reduced the risk of miscarriage. We did not find paternal age, alcohol consumption, or smoking status to be linked with early miscarriage. CONCLUSION(S): Our findings suggest that a healthy diet, regular physical activity, and planned pregnancy may be advantageous for women in pre-pregnancy or early pregnancy. Induced abortion, working night shifts, and frequent staying up late were associated with an increased risk of miscarriage. Further work in larger populations is warranted.
@article{xu_risk_2014,
	title = {Risk factors for early miscarriage among {Chinese}: a hospital-based case-control study},
	volume = {101},
	issn = {1556-5653},
	shorttitle = {Risk factors for early miscarriage among {Chinese}},
	doi = {10.1016/j.fertnstert.2014.02.013},
	abstract = {OBJECTIVE: To investigate the risk factors for early miscarriage among Chinese women.
DESIGN: Hospital-based matched case-control study.
SETTING: Academic medical center and maternal health hospital.
PATIENT(S): 620 women with early miscarriage (less than 13 weeks of gestation) and 1,240 normal pregnant women.
INTERVENTION(S): Face-to-face questionnaire.
MAIN OUTCOME MEASURE(S): Multivariable conditional odds ratio (OR) and 95\% confidence interval (CI) to measure risk factors.
RESULT(S): After adjustment for confounding factors, the following were independently associated with increased risk: history of miscarriage, repeated induced abortion, working night shifts, and frequent staying up late. Vitamin supplementation and regular physical activity reduced the risk of miscarriage. We did not find paternal age, alcohol consumption, or smoking status to be linked with early miscarriage.
CONCLUSION(S): Our findings suggest that a healthy diet, regular physical activity, and planned pregnancy may be advantageous for women in pre-pregnancy or early pregnancy. Induced abortion, working night shifts, and frequent staying up late were associated with an increased risk of miscarriage. Further work in larger populations is warranted.},
	language = {eng},
	number = {6},
	journal = {Fertility and Sterility},
	author = {Xu, Guangli and Wu, Yiming and Yang, Liming and Yuan, Lu and Guo, Huafeng and Zhang, Fuqing and Guan, Yichun and Yao, Wu},
	month = jun,
	year = {2014},
	pmid = {24666755},
	keywords = {Abortion, Induced, Abortion, Spontaneous, Academic Medical Centers, Adolescent, Adult, Asian Continental Ancestry Group, Case-Control Studies, Case-control study, China, Diet, Female, Gestational Age, Hospitals, Maternity, Humans, Job Description, Life Style, Logistic Models, Motor Activity, Multivariate Analysis, Odds Ratio, Personnel Staffing and Scheduling, Pregnancy, Risk Factors, Sleep, Surveys and Questionnaires, Time Factors, Young Adult, induced abortion, miscarriage, staying up late},
	pages = {1663--1670},
}

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