The B-Box-Containing MicroProtein miP1a/BBX31 Regulates Photomorphogenesis and UV-B Protection. Yadav, A., Bakshi, S., Yadukrishnan, P., Lingwan, M., Dolde, U., Wenkel, S., Masakapalli, S. K., & Datta, S. Plant Physiology, 179(4):1876–1892, April, 2019. ![The B-Box-Containing MicroProtein miP1a/BBX31 Regulates Photomorphogenesis and UV-B Protection [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex The bZIP transcription factor ELONGATED HYPOCOTYL5 (HY5) represents a major hub in the light-signaling cascade both under visible and UV-B light. The mode of transcriptional regulation of HY5, especially under UV-B light, is not well characterized. B-BOX (BBX) transcription factors regulate HY5 transcription and also posttranscriptionally modulate HY5 to control photomorphogenesis under white light. Here, we identify BBX31 as a key signaling intermediate in visible and UV-B light signal transduction in Arabidopsis (Arabidopsis thaliana). BBX31 expression is induced by UV-B radiation in a fluence-dependent manner. HY5 directly binds to the promoter of BBX31 and regulates its transcript levels. Loss- and gain-of-function mutants of BBX31 indicate that it acts as a negative regulator of photomorphogenesis under white light but is a positive regulator of UV-B signaling. Genetic interaction studies suggest that BBX31 regulates photomorphogenesis independent of HY5. We found no evidence for a direct BBX31-HY5 interaction, and they primarily regulate different sets of genes in white light. Under high doses of UV-B radiation, BBX31 promotes the accumulation of UV-protective flavonoids and phenolic compounds. It enhances tolerance to UV-B radiation by regulating genes involved in photoprotection and DNA repair in a HY5-dependent manner. Under UV-B radiation, overexpression of BBX31 enhances HY5 transcriptional levels in a UV RESISTANCE LOCUS8-dependent manner, suggesting that BBX31 might regulate HY5 transcription.
@article{yadav_b-box-containing_2019,
title = {The {B}-{Box}-{Containing} {MicroProtein} {miP1a}/{BBX31} {Regulates} {Photomorphogenesis} and {UV}-{B} {Protection}},
volume = {179},
issn = {0032-0889},
url = {https://doi.org/10.1104/pp.18.01258},
doi = {10.1104/pp.18.01258},
abstract = {The bZIP transcription factor ELONGATED HYPOCOTYL5 (HY5) represents a major hub in the light-signaling cascade both under visible and UV-B light. The mode of transcriptional regulation of HY5, especially under UV-B light, is not well characterized. B-BOX (BBX) transcription factors regulate HY5 transcription and also posttranscriptionally modulate HY5 to control photomorphogenesis under white light. Here, we identify BBX31 as a key signaling intermediate in visible and UV-B light signal transduction in Arabidopsis (Arabidopsis thaliana). BBX31 expression is induced by UV-B radiation in a fluence-dependent manner. HY5 directly binds to the promoter of BBX31 and regulates its transcript levels. Loss- and gain-of-function mutants of BBX31 indicate that it acts as a negative regulator of photomorphogenesis under white light but is a positive regulator of UV-B signaling. Genetic interaction studies suggest that BBX31 regulates photomorphogenesis independent of HY5. We found no evidence for a direct BBX31-HY5 interaction, and they primarily regulate different sets of genes in white light. Under high doses of UV-B radiation, BBX31 promotes the accumulation of UV-protective flavonoids and phenolic compounds. It enhances tolerance to UV-B radiation by regulating genes involved in photoprotection and DNA repair in a HY5-dependent manner. Under UV-B radiation, overexpression of BBX31 enhances HY5 transcriptional levels in a UV RESISTANCE LOCUS8-dependent manner, suggesting that BBX31 might regulate HY5 transcription.},
number = {4},
urldate = {2022-11-30},
journal = {Plant Physiology},
author = {Yadav, Arpita and Bakshi, Souvika and Yadukrishnan, Premachandran and Lingwan, Maneesh and Dolde, Ulla and Wenkel, Stephan and Masakapalli, Shyam Kumar and Datta, Sourav},
month = apr,
year = {2019},
pages = {1876--1892},
}
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B-BOX (BBX) transcription factors regulate HY5 transcription and also posttranscriptionally modulate HY5 to control photomorphogenesis under white light. Here, we identify BBX31 as a key signaling intermediate in visible and UV-B light signal transduction in Arabidopsis (Arabidopsis thaliana). BBX31 expression is induced by UV-B radiation in a fluence-dependent manner. HY5 directly binds to the promoter of BBX31 and regulates its transcript levels. Loss- and gain-of-function mutants of BBX31 indicate that it acts as a negative regulator of photomorphogenesis under white light but is a positive regulator of UV-B signaling. Genetic interaction studies suggest that BBX31 regulates photomorphogenesis independent of HY5. We found no evidence for a direct BBX31-HY5 interaction, and they primarily regulate different sets of genes in white light. Under high doses of UV-B radiation, BBX31 promotes the accumulation of UV-protective flavonoids and phenolic compounds. It enhances tolerance to UV-B radiation by regulating genes involved in photoprotection and DNA repair in a HY5-dependent manner. Under UV-B radiation, overexpression of BBX31 enhances HY5 transcriptional levels in a UV RESISTANCE LOCUS8-dependent manner, suggesting that BBX31 might regulate HY5 transcription.","number":"4","urldate":"2022-11-30","journal":"Plant Physiology","author":[{"propositions":[],"lastnames":["Yadav"],"firstnames":["Arpita"],"suffixes":[]},{"propositions":[],"lastnames":["Bakshi"],"firstnames":["Souvika"],"suffixes":[]},{"propositions":[],"lastnames":["Yadukrishnan"],"firstnames":["Premachandran"],"suffixes":[]},{"propositions":[],"lastnames":["Lingwan"],"firstnames":["Maneesh"],"suffixes":[]},{"propositions":[],"lastnames":["Dolde"],"firstnames":["Ulla"],"suffixes":[]},{"propositions":[],"lastnames":["Wenkel"],"firstnames":["Stephan"],"suffixes":[]},{"propositions":[],"lastnames":["Masakapalli"],"firstnames":["Shyam","Kumar"],"suffixes":[]},{"propositions":[],"lastnames":["Datta"],"firstnames":["Sourav"],"suffixes":[]}],"month":"April","year":"2019","pages":"1876–1892","bibtex":"@article{yadav_b-box-containing_2019,\n\ttitle = {The {B}-{Box}-{Containing} {MicroProtein} {miP1a}/{BBX31} {Regulates} {Photomorphogenesis} and {UV}-{B} {Protection}},\n\tvolume = {179},\n\tissn = {0032-0889},\n\turl = {https://doi.org/10.1104/pp.18.01258},\n\tdoi = {10.1104/pp.18.01258},\n\tabstract = {The bZIP transcription factor ELONGATED HYPOCOTYL5 (HY5) represents a major hub in the light-signaling cascade both under visible and UV-B light. 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