A prospective, randomized, controlled trial of noninvasive ventilation in pediatric acute respiratory failure. Yañez, L. J, Yunge, M., Emilfork, M., Lapadula, M., Alcántara, A., Fernández, C., Lozano, J., Contreras, M., Conto, L., Arevalo, C., Gayan, A., Hernández, F., Pedraza, M., Feddersen, M., Bejares, M., Morales, M., Mallea, F., Glasinovic, M., & Cavada, G. Pediatric Critical Care Medicine, 9(5):484–489, September, 2008. ![A prospective, randomized, controlled trial of noninvasive ventilation in pediatric acute respiratory failure [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex OUTCOMES:To compare the benefits of noninvasive ventilation (NIV) plus standard therapy vs. standard therapy alone in children with acute respiratory failure; assess method effectiveness in improving gas exchange and vital signs; and assess method safety. DESIGN:Prospective, randomized, controlled study. SITE: Two pediatric intensive care units in Santiago, Chile, at Clínica Santa María and Clínica Dávila, respectively. PATIENTS AND METHODS:Fifty patients with acute respiratory failure admitted to pediatric intensive care units were recruited; 25 patients were randomly allocated to noninvasive inspiratory positive airway pressure and expiratory positive airway pressure plus standard therapy (study group); the remaining 25 were given standard therapy (control group). Both groups were comparable in demographic terms. INTERVENTIONS AND MEASUREMENTS:The study group received NIV under inspiratory positive airway pressure ranging between 12 cm and 18 cm H2O and expiratory positive airway pressure between 6 cm and 12 cm H2O. Vital signs (cardiac and respiratory frequency), Po2, Pco2, pH, and Po2/Fio2 were recorded at the start and 1, 6, 12, 24, and 48 hrs into the study. RESULTS:Heart rate and respiratory rate improved significantly with NIV. Heart rate and respiratory rate were significantly lower after 1 hr of treatment compared with admission (p = 0.0009 and p = 0.004, respectively). The trend continued over time, heart rate being significantly lower than control after the first hour and heart rate after 6 hrs. With NIV, Po2/Fio2 improved significantly from the first hour. The endotracheal intubation was significantly lower (28%) in the NIV group than in the control group (60%; p = 0.045). CONCLUSIONS:NIV improves hypoxemia and the signs and symptoms of acute respiratory failure. NIV seems to afford these patients protection from endotracheal intubation.
@article{yanez_prospective_2008,
title = {A prospective, randomized, controlled trial of noninvasive ventilation in pediatric acute respiratory failure},
volume = {9},
url = {http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=18679148&retmode=ref&cmd=prlinks},
doi = {10.1097/pcc.0b013e318184989f},
abstract = {OUTCOMES:To compare the benefits of noninvasive ventilation (NIV) plus standard therapy vs. standard therapy alone in children with acute respiratory failure; assess method effectiveness in improving gas exchange and vital signs; and assess method safety. DESIGN:Prospective, randomized, controlled study. SITE: Two pediatric intensive care units in Santiago, Chile, at Clínica Santa María and Clínica Dávila, respectively. PATIENTS AND METHODS:Fifty patients with acute respiratory failure admitted to pediatric intensive care units were recruited; 25 patients were randomly allocated to noninvasive inspiratory positive airway pressure and expiratory positive airway pressure plus standard therapy (study group); the remaining 25 were given standard therapy (control group). Both groups were comparable in demographic terms. INTERVENTIONS AND MEASUREMENTS:The study group received NIV under inspiratory positive airway pressure ranging between 12 cm and 18 cm H2O and expiratory positive airway pressure between 6 cm and 12 cm H2O. Vital signs (cardiac and respiratory frequency), Po2, Pco2, pH, and Po2/Fio2 were recorded at the start and 1, 6, 12, 24, and 48 hrs into the study. RESULTS:Heart rate and respiratory rate improved significantly with NIV. Heart rate and respiratory rate were significantly lower after 1 hr of treatment compared with admission (p = 0.0009 and p = 0.004, respectively). The trend continued over time, heart rate being significantly lower than control after the first hour and heart rate after 6 hrs. With NIV, Po2/Fio2 improved significantly from the first hour. The endotracheal intubation was significantly lower (28\%) in the NIV group than in the control group (60\%; p = 0.045). CONCLUSIONS:NIV improves hypoxemia and the signs and symptoms of acute respiratory failure. NIV seems to afford these patients protection from endotracheal intubation.},
number = {5},
journal = {Pediatric Critical Care Medicine},
author = {Yañez, Leticia J and Yunge, Mauricio and Emilfork, Marcos and Lapadula, Michelangelo and Alcántara, Alex and Fernández, Carlos and Lozano, Jaime and Contreras, Mariana and Conto, Luis and Arevalo, Carlos and Gayan, Alejandro and Hernández, Flora and Pedraza, Mariela and Feddersen, Marion and Bejares, Marcela and Morales, Marta and Mallea, Fernando and Glasinovic, Maritza and Cavada, Gabriel},
month = sep,
year = {2008},
pages = {484--489},
}
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J","Yunge, M.","Emilfork, M.","Lapadula, M.","Alcántara, A.","Fernández, C.","Lozano, J.","Contreras, M.","Conto, L.","Arevalo, C.","Gayan, A.","Hernández, F.","Pedraza, M.","Feddersen, M.","Bejares, M.","Morales, M.","Mallea, F.","Glasinovic, M.","Cavada, G."],"year":2008,"bibtype":"article","biburl":"http://bibbase.org/zotero-group/gxu917/1345589","bibdata":{"bibtype":"article","type":"article","title":"A prospective, randomized, controlled trial of noninvasive ventilation in pediatric acute respiratory failure","volume":"9","url":"http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=18679148&retmode=ref&cmd=prlinks","doi":"10.1097/pcc.0b013e318184989f","abstract":"OUTCOMES:To compare the benefits of noninvasive ventilation (NIV) plus standard therapy vs. standard therapy alone in children with acute respiratory failure; assess method effectiveness in improving gas exchange and vital signs; and assess method safety. DESIGN:Prospective, randomized, controlled study. SITE: Two pediatric intensive care units in Santiago, Chile, at Clínica Santa María and Clínica Dávila, respectively. PATIENTS AND METHODS:Fifty patients with acute respiratory failure admitted to pediatric intensive care units were recruited; 25 patients were randomly allocated to noninvasive inspiratory positive airway pressure and expiratory positive airway pressure plus standard therapy (study group); the remaining 25 were given standard therapy (control group). Both groups were comparable in demographic terms. INTERVENTIONS AND MEASUREMENTS:The study group received NIV under inspiratory positive airway pressure ranging between 12 cm and 18 cm H2O and expiratory positive airway pressure between 6 cm and 12 cm H2O. Vital signs (cardiac and respiratory frequency), Po2, Pco2, pH, and Po2/Fio2 were recorded at the start and 1, 6, 12, 24, and 48 hrs into the study. RESULTS:Heart rate and respiratory rate improved significantly with NIV. Heart rate and respiratory rate were significantly lower after 1 hr of treatment compared with admission (p = 0.0009 and p = 0.004, respectively). The trend continued over time, heart rate being significantly lower than control after the first hour and heart rate after 6 hrs. With NIV, Po2/Fio2 improved significantly from the first hour. The endotracheal intubation was significantly lower (28%) in the NIV group than in the control group (60%; p = 0.045). CONCLUSIONS:NIV improves hypoxemia and the signs and symptoms of acute respiratory failure. NIV seems to afford these patients protection from endotracheal intubation.","number":"5","journal":"Pediatric Critical Care Medicine","author":[{"propositions":[],"lastnames":["Yañez"],"firstnames":["Leticia","J"],"suffixes":[]},{"propositions":[],"lastnames":["Yunge"],"firstnames":["Mauricio"],"suffixes":[]},{"propositions":[],"lastnames":["Emilfork"],"firstnames":["Marcos"],"suffixes":[]},{"propositions":[],"lastnames":["Lapadula"],"firstnames":["Michelangelo"],"suffixes":[]},{"propositions":[],"lastnames":["Alcántara"],"firstnames":["Alex"],"suffixes":[]},{"propositions":[],"lastnames":["Fernández"],"firstnames":["Carlos"],"suffixes":[]},{"propositions":[],"lastnames":["Lozano"],"firstnames":["Jaime"],"suffixes":[]},{"propositions":[],"lastnames":["Contreras"],"firstnames":["Mariana"],"suffixes":[]},{"propositions":[],"lastnames":["Conto"],"firstnames":["Luis"],"suffixes":[]},{"propositions":[],"lastnames":["Arevalo"],"firstnames":["Carlos"],"suffixes":[]},{"propositions":[],"lastnames":["Gayan"],"firstnames":["Alejandro"],"suffixes":[]},{"propositions":[],"lastnames":["Hernández"],"firstnames":["Flora"],"suffixes":[]},{"propositions":[],"lastnames":["Pedraza"],"firstnames":["Mariela"],"suffixes":[]},{"propositions":[],"lastnames":["Feddersen"],"firstnames":["Marion"],"suffixes":[]},{"propositions":[],"lastnames":["Bejares"],"firstnames":["Marcela"],"suffixes":[]},{"propositions":[],"lastnames":["Morales"],"firstnames":["Marta"],"suffixes":[]},{"propositions":[],"lastnames":["Mallea"],"firstnames":["Fernando"],"suffixes":[]},{"propositions":[],"lastnames":["Glasinovic"],"firstnames":["Maritza"],"suffixes":[]},{"propositions":[],"lastnames":["Cavada"],"firstnames":["Gabriel"],"suffixes":[]}],"month":"September","year":"2008","pages":"484–489","bibtex":"@article{yanez_prospective_2008,\n\ttitle = {A prospective, randomized, controlled trial of noninvasive ventilation in pediatric acute respiratory failure},\n\tvolume = {9},\n\turl = {http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=18679148&retmode=ref&cmd=prlinks},\n\tdoi = {10.1097/pcc.0b013e318184989f},\n\tabstract = {OUTCOMES:To compare the benefits of noninvasive ventilation (NIV) plus standard therapy vs. standard therapy alone in children with acute respiratory failure; assess method effectiveness in improving gas exchange and vital signs; and assess method safety. DESIGN:Prospective, randomized, controlled study. SITE: Two pediatric intensive care units in Santiago, Chile, at Clínica Santa María and Clínica Dávila, respectively. PATIENTS AND METHODS:Fifty patients with acute respiratory failure admitted to pediatric intensive care units were recruited; 25 patients were randomly allocated to noninvasive inspiratory positive airway pressure and expiratory positive airway pressure plus standard therapy (study group); the remaining 25 were given standard therapy (control group). Both groups were comparable in demographic terms. INTERVENTIONS AND MEASUREMENTS:The study group received NIV under inspiratory positive airway pressure ranging between 12 cm and 18 cm H2O and expiratory positive airway pressure between 6 cm and 12 cm H2O. Vital signs (cardiac and respiratory frequency), Po2, Pco2, pH, and Po2/Fio2 were recorded at the start and 1, 6, 12, 24, and 48 hrs into the study. RESULTS:Heart rate and respiratory rate improved significantly with NIV. Heart rate and respiratory rate were significantly lower after 1 hr of treatment compared with admission (p = 0.0009 and p = 0.004, respectively). The trend continued over time, heart rate being significantly lower than control after the first hour and heart rate after 6 hrs. With NIV, Po2/Fio2 improved significantly from the first hour. The endotracheal intubation was significantly lower (28\\%) in the NIV group than in the control group (60\\%; p = 0.045). CONCLUSIONS:NIV improves hypoxemia and the signs and symptoms of acute respiratory failure. 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