@article{yaguchi_evolution_2019,
	title = {Evolution of nitric oxide regulation of gut function},
	volume = {116},
	issn = {0027-8424, 1091-6490},
	url = {http://www.pnas.org/lookup/doi/10.1073/pnas.1816973116},
	doi = {10.1073/pnas.1816973116},
	abstract = {Although morphologies are diverse, the common pattern in bilaterians is for passage of food in the gut to be controlled by nerves and endodermally derived neuron-like cells. In vertebrates, nitric oxide (NO) derived from enteric nerves controls relaxation of the pyloric sphincter. Here, we show that in the larvae of sea urchins, there are endoderm-derived neuronal nitric oxide synthase (nNOS)-positive cells expressing pan-neural marker, Synaptotagmin-B (SynB), in sphincters and that NO regulates the relaxation of the pyloric sphincter. Our results indicate that NO-dependent pylorus regulation is a shared feature within the deuterostomes, and we speculate that it was a characteristic of stem deuterostomes.},
	language = {en},
	number = {12},
	urldate = {2021-07-27},
	journal = {Proceedings of the National Academy of Sciences},
	author = {Yaguchi, Junko and Yaguchi, Shunsuke},
	month = mar,
	year = {2019},
	pages = {5607--5612},
}

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