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@article{yaguchi_meis_2018,
	title = {Meis transcription factor maintains the neurogenic ectoderm and regulates the anterior-posterior patterning in embryos of a sea urchin, {Hemicentrotus} pulcherrimus},
	volume = {444},
	issn = {0012-1606},
	url = {http://www.sciencedirect.com/science/article/pii/S0012160618304287},
	doi = {10.1016/j.ydbio.2018.09.018},
	abstract = {Precise body axis formation is an essential step in the development of multicellular organisms, for most of which the molecular gradient and/or specifically biased localization of cell-fate determinants in eggs play important roles. In sea urchins, however, any biased proteins and mRNAs have not yet been identified in the egg except for vegetal cortex molecules, suggesting that sea urchin development is mostly regulated by uniformly distributed maternal molecules with contributions to axis formation that are not well characterized. Here, we describe that the maternal Meis transcription factor regulates anterior-posterior axis formation through maintenance of the most anterior territory in embryos of a sea urchin, Hemicentrotus pulcherrimus. Loss-of-function experiments revealed that Meis is intrinsically required for maintenance of the anterior neuroectoderm specifier foxQ2 after hatching and, consequently, the morphant lost anterior neuroectoderm characteristics. In addition, the expression patterns of univin and VEGF, the lateral ectoderm markers, and the mesenchyme-cell pattern shifted toward the anterior side in Meis morphants more than they did in control embryos, indicating that Meis contributes to the precise anteroposterior patterning by regulating the anterior neuroectodermal fate.},
	number = {1},
	journal = {Developmental Biology},
	author = {Yaguchi, Junko and Yamazaki, Atsuko and Yaguchi, Shunsuke},
	month = dec,
	year = {2018},
	keywords = {Yaguchi S},
	pages = {1--8}
}