@article{ yalcin_effects_2008,
  title = {Effects of 5,7-dihydroxytryptamine lesion of the dorsal raphe nucleus on the antidepressant-like action of tramadol in the unpredictable chronic mild stress in mice},
  volume = {200},
  issn = {0033-3158},
  doi = {10.1007/s00213-008-1227-3},
  abstract = {{RATIONALE}: Tramadol is a centrally acting clinically effective analgesic, with a weak opioid receptor affinity. It shows antidepressant-like effects in animal models such as forced swimming test, learned helplessness, and unpredictable chronic mild stress ({UCMS}) and enhances the concentrations of noradrenaline ({NA}) and serotonin (5-{HT}) by interfering with their reuptake and release mechanisms, like some antidepressants.
{OBJECTIVES}: The aim of this study was to explore whether the antidepressant-like effects of tramadol is affected by the serotonergic system. For this purpose, the effects of a lesion of the dorsal raphe nucleus ({DRN}) by 5,7-dihydroxytryptamine (5,7-{DHT}) on the action of tramadol (20 mg/kg, i.p.) on depression-related behavior and neurochemical correlates were investigated in mice. From the third week onward, we administered tramadol chronically during 4 weeks.
{RESULTS}: Tramadol reversed the physical and behavioral abnormalities induced by the {UCMS}. Furthermore, the lesion of the {DRN} by 5,7-{DHT} antagonized the antidepressant-like effects of tramadol on the coat state, in the splash test but not in the resident-intruder test. The results obtained by high-pressure liquid chromatography showed that the level of 5-{HT} was reduced by the lesion in some brain regions without affecting the level of {NA}. Moreover, while the {UCMS} regimen diminished the level of 5-{HT}, tramadol increased the level of this neurotransmitter in certain regions.
{CONCLUSIONS}: These results seem to indicate that the serotonergic system is critically involved in the antidepressant-like effects of tramadol in the {UCMS} in mice.},
  language = {eng},
  number = {4},
  journal = {Psychopharmacology},
  author = {Yalcin, Ipek and Coubard, Stéphanie and Bodard, Sylvie and Chalon, Sylvie and Belzung, Catherine},
  month = {November},
  year = {2008},
  pmid = {18581097},
  keywords = {5,7-Dihydroxytryptamine, Animals, Antidepressive Agents, Behavior, Animal, Brain, Chromatography, High Pressure Liquid, Depression, Disease Models, Animal, Male, Mice, Mice, Inbred {BALB} C, Raphe Nuclei, Serotonin, Stress, Psychological, Tramadol},
  pages = {497--507}
}

{"_id":"wtErxjHfnwhMsFGQt","authorIDs":[],"author_short":["Yalcin, I.","Coubard, S.","Bodard, S.","Chalon, S.","Belzung, C."],"bibbaseid":"yalcin-coubard-bodard-chalon-belzung-effectsof57dihydroxytryptaminelesionofthedorsalraphenucleusontheantidepressantlikeactionoftramadolintheunpredictablechronicmildstressinmice-2008","bibdata":{"abstract":"RATIONALE: Tramadol is a centrally acting clinically effective analgesic, with a weak opioid receptor affinity. It shows antidepressant-like effects in animal models such as forced swimming test, learned helplessness, and unpredictable chronic mild stress (UCMS) and enhances the concentrations of noradrenaline (NA) and serotonin (5-HT) by interfering with their reuptake and release mechanisms, like some antidepressants. OBJECTIVES: The aim of this study was to explore whether the antidepressant-like effects of tramadol is affected by the serotonergic system. For this purpose, the effects of a lesion of the dorsal raphe nucleus (DRN) by 5,7-dihydroxytryptamine (5,7-DHT) on the action of tramadol (20 mg/kg, i.p.) on depression-related behavior and neurochemical correlates were investigated in mice. From the third week onward, we administered tramadol chronically during 4 weeks. RESULTS: Tramadol reversed the physical and behavioral abnormalities induced by the UCMS. Furthermore, the lesion of the DRN by 5,7-DHT antagonized the antidepressant-like effects of tramadol on the coat state, in the splash test but not in the resident-intruder test. The results obtained by high-pressure liquid chromatography showed that the level of 5-HT was reduced by the lesion in some brain regions without affecting the level of NA. Moreover, while the UCMS regimen diminished the level of 5-HT, tramadol increased the level of this neurotransmitter in certain regions. CONCLUSIONS: These results seem to indicate that the serotonergic system is critically involved in the antidepressant-like effects of tramadol in the UCMS in mice.","author":["Yalcin, Ipek","Coubard, Stéphanie","Bodard, Sylvie","Chalon, Sylvie","Belzung, Catherine"],"author_short":["Yalcin, I.","Coubard, S.","Bodard, S.","Chalon, S.","Belzung, C."],"bibtex":"@article{ yalcin_effects_2008,\n title = {Effects of 5,7-dihydroxytryptamine lesion of the dorsal raphe nucleus on the antidepressant-like action of tramadol in the unpredictable chronic mild stress in mice},\n volume = {200},\n issn = {0033-3158},\n doi = {10.1007/s00213-008-1227-3},\n abstract = {{RATIONALE}: Tramadol is a centrally acting clinically effective analgesic, with a weak opioid receptor affinity. It shows antidepressant-like effects in animal models such as forced swimming test, learned helplessness, and unpredictable chronic mild stress ({UCMS}) and enhances the concentrations of noradrenaline ({NA}) and serotonin (5-{HT}) by interfering with their reuptake and release mechanisms, like some antidepressants.\n{OBJECTIVES}: The aim of this study was to explore whether the antidepressant-like effects of tramadol is affected by the serotonergic system. For this purpose, the effects of a lesion of the dorsal raphe nucleus ({DRN}) by 5,7-dihydroxytryptamine (5,7-{DHT}) on the action of tramadol (20 mg/kg, i.p.) on depression-related behavior and neurochemical correlates were investigated in mice. From the third week onward, we administered tramadol chronically during 4 weeks.\n{RESULTS}: Tramadol reversed the physical and behavioral abnormalities induced by the {UCMS}. Furthermore, the lesion of the {DRN} by 5,7-{DHT} antagonized the antidepressant-like effects of tramadol on the coat state, in the splash test but not in the resident-intruder test. The results obtained by high-pressure liquid chromatography showed that the level of 5-{HT} was reduced by the lesion in some brain regions without affecting the level of {NA}. Moreover, while the {UCMS} regimen diminished the level of 5-{HT}, tramadol increased the level of this neurotransmitter in certain regions.\n{CONCLUSIONS}: These results seem to indicate that the serotonergic system is critically involved in the antidepressant-like effects of tramadol in the {UCMS} in mice.},\n language = {eng},\n number = {4},\n journal = {Psychopharmacology},\n author = {Yalcin, Ipek and Coubard, Stéphanie and Bodard, Sylvie and Chalon, Sylvie and Belzung, Catherine},\n month = {November},\n year = {2008},\n pmid = {18581097},\n keywords = {5,7-Dihydroxytryptamine, Animals, Antidepressive Agents, Behavior, Animal, Brain, Chromatography, High Pressure Liquid, Depression, Disease Models, Animal, Male, Mice, Mice, Inbred {BALB} C, Raphe Nuclei, Serotonin, Stress, Psychological, Tramadol},\n pages = {497--507}\n}","bibtype":"article","doi":"10.1007/s00213-008-1227-3","id":"yalcin_effects_2008","issn":"0033-3158","journal":"Psychopharmacology","key":"yalcin_effects_2008","keywords":"5,7-Dihydroxytryptamine, Animals, Antidepressive Agents, Behavior, Animal, Brain, Chromatography, High Pressure Liquid, Depression, Disease Models, Animal, Male, Mice, Mice, Inbred BALB C, Raphe Nuclei, Serotonin, Stress, Psychological, Tramadol","language":"eng","month":"November","number":"4","pages":"497--507","pmid":"18581097","title":"Effects of 5,7-dihydroxytryptamine lesion of the dorsal raphe nucleus on the antidepressant-like action of tramadol in the unpredictable chronic mild stress in mice","type":"article","volume":"200","year":"2008","bibbaseid":"yalcin-coubard-bodard-chalon-belzung-effectsof57dihydroxytryptaminelesionofthedorsalraphenucleusontheantidepressantlikeactionoftramadolintheunpredictablechronicmildstressinmice-2008","role":"author","urls":{},"keyword":["5","7-Dihydroxytryptamine","Animals","Antidepressive Agents","Behavior","Animal","Brain","Chromatography","High Pressure Liquid","Depression","Disease Models","Animal","Male","Mice","Mice","Inbred BALB C","Raphe Nuclei","Serotonin","Stress","Psychological","Tramadol"],"downloads":0},"bibtype":"article","biburl":"https://api.zotero.org/users/1159944/collections/M6TABHZN/items?key=1pvuA2LY3hAaGNWuGNZF2QkP&format=bibtex&limit=100","creationDate":"2015-02-11T08:49:19.891Z","downloads":0,"keywords":["5","7-dihydroxytryptamine","animals","antidepressive agents","behavior","animal","brain","chromatography","high pressure liquid","depression","disease models","animal","male","mice","mice","inbred balb c","raphe nuclei","serotonin","stress","psychological","tramadol"],"search_terms":["effects","dihydroxytryptamine","lesion","dorsal","raphe","nucleus","antidepressant","action","tramadol","unpredictable","chronic","mild","stress","mice","yalcin","coubard","bodard","chalon","belzung"],"title":"Effects of 5,7-dihydroxytryptamine lesion of the dorsal raphe nucleus on the antidepressant-like action of tramadol in the unpredictable chronic mild stress in mice","year":2008,"dataSources":["Jekqva3EtgNgLZ4ic"]}