@misc{yancy_jr._w.s._efficacy_2013,
	title = {Efficacy and tolerability of treatments for chronic cough: {A} systematic review and meta-analysis},
	url = {http://journal.publications.chestnet.org/data/Journals/CHEST/928990/chest_144_6_1827.pdf},
	abstract = {Background: Understanding the comparative effectiveness of treatments for patients with unexplained or refractory cough is important to increase awareness of proven therapies and their potential adverse effects in this unique population. Methods: We performed a literature search for English-language studies published up to June 2012 that compared symptomatic therapies for chronic cough. Two investigators screened each abstract and full-text article for inclusion, abstracted data, and rated quality. Meta-analysis with random-effects models was used to summarize effects of treatments. Results: We identified 49 studies (3,067 patients) comprising 68 therapeutic comparisons. Of the studied agents, opioid and certain nonopioid and nonanesthetic antitussives had demonstrated efficacy for chronic cough in adults. Compared with placebo, effect sizes (standardized mean differences for cough severity and rate ratios for cough frequency) for opioids were 0.55 (95\% CI, 0.38-0.72; P {\textless} .0001) and 0.57 (95\% CI, 0.36-0.91; P = .0260), respectively. For dextromethorphan, effect sizes were 0.37 (95\% CI, 0.19-0.56; P = .0008) and 0.40 (95\% CI, 0.18-0.85; P = .0248), respectively. The overall strength of evidence was limited by inconsistency and imprecision of results and by small numbers of direct comparisons. Nonpharmacologic therapies and the management of cough in children were infrequently studied. Conclusions: Although evidence is limited, opioid and certain nonopioid and nonanesthetic antitussives demonstrated efficacy for treating chronic cough in adults. There is a need for further studies in patients with unexplained or refractory cough as well as for more systematic study designs, assessment of patient-centered outcomes, and reporting. © 2013 American College of Chest Physicians.},
	journal = {Chest},
	author = {{Yancy Jr. W.S.} and {McCrory D.C.} and {Coeytaux R.R.} and {Schmit K.M.} and {Kemper A.R.} and {Goode A.} and {Hasselblad V.} and {Heidenfelder B.L.} and {Sanders G.D.}},
	year = {2013},
	keywords = {*chronic cough, *chronic cough/dt [Drug Therapy], *meta analysis, *systematic review, Child, acetylcysteine/dt [Drug Therapy], adult, adverse drug reaction, ambroxol/dt [Drug Therapy], amoxicillin/dt [Drug Therapy], antitussive agent, antitussive agent/cm [Drug Comparison], antitussive agent/dt [Drug Therapy], article, beclometasone/dt [Drug Therapy], benzonatate/cm [Drug Comparison], benzonatate/ct [Clinical Trial], benzonatate/dt [Drug Therapy], bromhexine/dt [Drug Therapy], chronic cough/dt [Drug Therapy], clinical trial (topic), clofedanol/cm [Drug Comparison], clofedanol/dt [Drug Therapy], codeine/ae [Adverse Drug Reaction], codeine/cm [Drug Comparison], codeine/do [Drug Dose], codeine/dt [Drug Therapy], comparative effectiveness, constipation/si [Side Effect], coughing, dextromethorphan, dextromethorphan/ae [Adverse Drug Reaction], dextromethorphan/cm [Drug Comparison], dextromethorphan/dt [Drug Therapy], dihydrocodeine/ae [Adverse Drug Reaction], dihydrocodeine/cm [Drug Comparison], dihydrocodeine/dt [Drug Therapy], disease severity, drowsiness/si [Side Effect], drug efficacy, drug tolerability, drug withdrawal, effect size, erythromycin/dt [Drug Therapy], fluticasone/dt [Drug Therapy], forced expiration, glaucine/cm [Drug Comparison], glaucine/dt [Drug Therapy], glycerol/dt [Drug Therapy], guaifenesin/dt [Drug Therapy], human, ipratropium bromide/dt [Drug Therapy], ipratropium bromide/ih [Inhalational Drug Administration], isoaminile citrate/cm [Drug Comparison], isoaminile citrate/dt [Drug Therapy], ketotifen/dt [Drug Therapy], language, levdropropizine/ae [Adverse Drug Reaction], levdropropizine/cm [Drug Comparison], levdropropizine/dt [Drug Therapy], levocloperastine/cm [Drug Comparison], levocloperastine/dt [Drug Therapy], loratadine/dt [Drug Therapy], mesna/dt [Drug Therapy], meta analysis, model, moguisteine/cm [Drug Comparison], moguisteine/dt [Drug Therapy], morphine/ae [Adverse Drug Reaction], morphine/dt [Drug Therapy], nausea/si [Side Effect], opiate, opiate/cm [Drug Comparison], opiate/dt [Drug Therapy], patient, placebo, placebo effect, population, positive end expiratory pressure, priority journal, quality of life, somnolence/si [Side Effect], study design, systematic review, therapy, unclassified drug, unspecified side effect/si [Side Effect], viminol/dt [Drug Therapy]}
}

{"_id":"7jAXziRpiax6YSxHD","bibbaseid":"yancyjrws-mccrorydc-coeytauxrr-schmitkm-kemperar-goodea-hasselbladv-heidenfelderbl-etal-efficacyandtolerabilityoftreatmentsforchroniccoughasystematicreviewandmetaanalysis-2013","downloads":0,"creationDate":"2017-05-12T20:20:57.700Z","title":"Efficacy and tolerability of treatments for chronic cough: A systematic review and meta-analysis","author_short":["Yancy Jr. W.S.","McCrory D.C.","Coeytaux R.R.","Schmit K.M.","Kemper A.R.","Goode A.","Hasselblad V.","Heidenfelder B.L.","Sanders G.D."],"year":2013,"bibtype":"misc","biburl":"http://bibbase.org/zotero/gxu917","bibdata":{"bibtype":"misc","type":"misc","title":"Efficacy and tolerability of treatments for chronic cough: A systematic review and meta-analysis","url":"http://journal.publications.chestnet.org/data/Journals/CHEST/928990/chest_144_6_1827.pdf","abstract":"Background: Understanding the comparative effectiveness of treatments for patients with unexplained or refractory cough is important to increase awareness of proven therapies and their potential adverse effects in this unique population. Methods: We performed a literature search for English-language studies published up to June 2012 that compared symptomatic therapies for chronic cough. Two investigators screened each abstract and full-text article for inclusion, abstracted data, and rated quality. Meta-analysis with random-effects models was used to summarize effects of treatments. Results: We identified 49 studies (3,067 patients) comprising 68 therapeutic comparisons. Of the studied agents, opioid and certain nonopioid and nonanesthetic antitussives had demonstrated efficacy for chronic cough in adults. Compared with placebo, effect sizes (standardized mean differences for cough severity and rate ratios for cough frequency) for opioids were 0.55 (95% CI, 0.38-0.72; P \\textless .0001) and 0.57 (95% CI, 0.36-0.91; P = .0260), respectively. For dextromethorphan, effect sizes were 0.37 (95% CI, 0.19-0.56; P = .0008) and 0.40 (95% CI, 0.18-0.85; P = .0248), respectively. The overall strength of evidence was limited by inconsistency and imprecision of results and by small numbers of direct comparisons. Nonpharmacologic therapies and the management of cough in children were infrequently studied. Conclusions: Although evidence is limited, opioid and certain nonopioid and nonanesthetic antitussives demonstrated efficacy for treating chronic cough in adults. There is a need for further studies in patients with unexplained or refractory cough as well as for more systematic study designs, assessment of patient-centered outcomes, and reporting. © 2013 American College of Chest Physicians.","journal":"Chest","author":[{"firstnames":[],"propositions":[],"lastnames":["Yancy Jr. W.S."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["McCrory D.C."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Coeytaux R.R."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Schmit K.M."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Kemper A.R."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Goode A."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Hasselblad V."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Heidenfelder B.L."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Sanders G.D."],"suffixes":[]}],"year":"2013","keywords":"*chronic cough, *chronic cough/dt [Drug Therapy], *meta analysis, *systematic review, Child, acetylcysteine/dt [Drug Therapy], adult, adverse drug reaction, ambroxol/dt [Drug Therapy], amoxicillin/dt [Drug Therapy], antitussive agent, antitussive agent/cm [Drug Comparison], antitussive agent/dt [Drug Therapy], article, beclometasone/dt [Drug Therapy], benzonatate/cm [Drug Comparison], benzonatate/ct [Clinical Trial], benzonatate/dt [Drug Therapy], bromhexine/dt [Drug Therapy], chronic cough/dt [Drug Therapy], clinical trial (topic), clofedanol/cm [Drug Comparison], clofedanol/dt [Drug Therapy], codeine/ae [Adverse Drug Reaction], codeine/cm [Drug Comparison], codeine/do [Drug Dose], codeine/dt [Drug Therapy], comparative effectiveness, constipation/si [Side Effect], coughing, dextromethorphan, dextromethorphan/ae [Adverse Drug Reaction], dextromethorphan/cm [Drug Comparison], dextromethorphan/dt [Drug Therapy], dihydrocodeine/ae [Adverse Drug Reaction], dihydrocodeine/cm [Drug Comparison], dihydrocodeine/dt [Drug Therapy], disease severity, drowsiness/si [Side Effect], drug efficacy, drug tolerability, drug withdrawal, effect size, erythromycin/dt [Drug Therapy], fluticasone/dt [Drug Therapy], forced expiration, glaucine/cm [Drug Comparison], glaucine/dt [Drug Therapy], glycerol/dt [Drug Therapy], guaifenesin/dt [Drug Therapy], human, ipratropium bromide/dt [Drug Therapy], ipratropium bromide/ih [Inhalational Drug Administration], isoaminile citrate/cm [Drug Comparison], isoaminile citrate/dt [Drug Therapy], ketotifen/dt [Drug Therapy], language, levdropropizine/ae [Adverse Drug Reaction], levdropropizine/cm [Drug Comparison], levdropropizine/dt [Drug Therapy], levocloperastine/cm [Drug Comparison], levocloperastine/dt [Drug Therapy], loratadine/dt [Drug Therapy], mesna/dt [Drug Therapy], meta analysis, model, moguisteine/cm [Drug Comparison], moguisteine/dt [Drug Therapy], morphine/ae [Adverse Drug Reaction], morphine/dt [Drug Therapy], nausea/si [Side Effect], opiate, opiate/cm [Drug Comparison], opiate/dt [Drug Therapy], patient, placebo, placebo effect, population, positive end expiratory pressure, priority journal, quality of life, somnolence/si [Side Effect], study design, systematic review, therapy, unclassified drug, unspecified side effect/si [Side Effect], viminol/dt [Drug Therapy]","bibtex":"@misc{yancy_jr._w.s._efficacy_2013,\n\ttitle = {Efficacy and tolerability of treatments for chronic cough: {A} systematic review and meta-analysis},\n\turl = {http://journal.publications.chestnet.org/data/Journals/CHEST/928990/chest_144_6_1827.pdf},\n\tabstract = {Background: Understanding the comparative effectiveness of treatments for patients with unexplained or refractory cough is important to increase awareness of proven therapies and their potential adverse effects in this unique population. Methods: We performed a literature search for English-language studies published up to June 2012 that compared symptomatic therapies for chronic cough. Two investigators screened each abstract and full-text article for inclusion, abstracted data, and rated quality. Meta-analysis with random-effects models was used to summarize effects of treatments. Results: We identified 49 studies (3,067 patients) comprising 68 therapeutic comparisons. Of the studied agents, opioid and certain nonopioid and nonanesthetic antitussives had demonstrated efficacy for chronic cough in adults. Compared with placebo, effect sizes (standardized mean differences for cough severity and rate ratios for cough frequency) for opioids were 0.55 (95\\% CI, 0.38-0.72; P {\\textless} .0001) and 0.57 (95\\% CI, 0.36-0.91; P = .0260), respectively. For dextromethorphan, effect sizes were 0.37 (95\\% CI, 0.19-0.56; P = .0008) and 0.40 (95\\% CI, 0.18-0.85; P = .0248), respectively. The overall strength of evidence was limited by inconsistency and imprecision of results and by small numbers of direct comparisons. Nonpharmacologic therapies and the management of cough in children were infrequently studied. Conclusions: Although evidence is limited, opioid and certain nonopioid and nonanesthetic antitussives demonstrated efficacy for treating chronic cough in adults. There is a need for further studies in patients with unexplained or refractory cough as well as for more systematic study designs, assessment of patient-centered outcomes, and reporting. © 2013 American College of Chest Physicians.},\n\tjournal = {Chest},\n\tauthor = {{Yancy Jr. W.S.} and {McCrory D.C.} and {Coeytaux R.R.} and {Schmit K.M.} and {Kemper A.R.} and {Goode A.} and {Hasselblad V.} and {Heidenfelder B.L.} and {Sanders G.D.}},\n\tyear = {2013},\n\tkeywords = {*chronic cough, *chronic cough/dt [Drug Therapy], *meta analysis, *systematic review, Child, acetylcysteine/dt [Drug Therapy], adult, adverse drug reaction, ambroxol/dt [Drug Therapy], amoxicillin/dt [Drug Therapy], antitussive agent, antitussive agent/cm [Drug Comparison], antitussive agent/dt [Drug Therapy], article, beclometasone/dt [Drug Therapy], benzonatate/cm [Drug Comparison], benzonatate/ct [Clinical Trial], benzonatate/dt [Drug Therapy], bromhexine/dt [Drug Therapy], chronic cough/dt [Drug Therapy], clinical trial (topic), clofedanol/cm [Drug Comparison], clofedanol/dt [Drug Therapy], codeine/ae [Adverse Drug Reaction], codeine/cm [Drug Comparison], codeine/do [Drug Dose], codeine/dt [Drug Therapy], comparative effectiveness, constipation/si [Side Effect], coughing, dextromethorphan, dextromethorphan/ae [Adverse Drug Reaction], dextromethorphan/cm [Drug Comparison], dextromethorphan/dt [Drug Therapy], dihydrocodeine/ae [Adverse Drug Reaction], dihydrocodeine/cm [Drug Comparison], dihydrocodeine/dt [Drug Therapy], disease severity, drowsiness/si [Side Effect], drug efficacy, drug tolerability, drug withdrawal, effect size, erythromycin/dt [Drug Therapy], fluticasone/dt [Drug Therapy], forced expiration, glaucine/cm [Drug Comparison], glaucine/dt [Drug Therapy], glycerol/dt [Drug Therapy], guaifenesin/dt [Drug Therapy], human, ipratropium bromide/dt [Drug Therapy], ipratropium bromide/ih [Inhalational Drug Administration], isoaminile citrate/cm [Drug Comparison], isoaminile citrate/dt [Drug 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