Supramolecular ABC Triblock Copolymers via One-Pot, Orthogonal Self-Assembly. Yang, S., K., Ambade, A., V., & Weck, M. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 132(5):1637-1645, AMER CHEMICAL SOC, 2, 2010.
abstract   bibtex   
A heterotelechelic poly(norbornene imide) containing two terminal and orthogonal hydrogen-bonding receptors, N,N'-bis[6-(alkanoylamino)pyridin-2-yl] isophthalamide (often referred to as the Hamilton receptor or Wedge) and 2,7-diamido-1,8-naphthyridine (DAN), at the opposite ends of the polymer was synthesized via ring-opening metathesis polymerization (ROMP) through the employment of a Hamilton receptor-functionalized ruthenium initiator and a DAN-based chain-terminator. In parallel, two monotelechelic polymers containing either cyanuric acid (CA)- or ureidoguanosine (UG)-end groups that are complementary to the hydrogen-bonding receptors along the poly(norbornene imide) were synthesized either also via ROMP by terminating the polymerization of norbornene octyl ester with a CA-based chain-terminator or by the reaction of poly(ethylene oxide) with UG. Complete incorporations of the hydrogen-bonding receptors at the chain-ends of all polymers were confirmed by (1)H NMR spectroscopy. The telechelic polymers can be self-assembled into ABC triblock copolymers following either a stepwise or a one-pot, orthogonal self-assembly protocol. The self-assembly process was monitored by (1)H NMR spectroscopy, revealing full orthogonality of the two recognition pairs, Hamilton receptor-CA and DAN-UG. The resulting supramolecular ABC triblock copolymers were further characterized by a series of methods including 2-D NOESY, isothermal titration calorimetry, and viscometry, proving that the two orthogonal hydrogen-bonding interactions are strong enough to hold the three polymer chains together. We suggest that a self-assembly methodology solely based on the fully orthogonal hydrogen-bonding recognition motifs will allow for an easy and rapid synthesis of architecturally controlled supramolecular polymeric assemblies with a high degree of complexity.
@article{
 title = {Supramolecular ABC Triblock Copolymers via One-Pot, Orthogonal Self-Assembly},
 type = {article},
 year = {2010},
 identifiers = {[object Object]},
 pages = {1637-1645},
 volume = {132},
 month = {2},
 publisher = {AMER CHEMICAL SOC},
 city = {1155 16TH ST, NW, WASHINGTON, DC 20036 USA},
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 last_modified = {2017-03-14T12:30:08.401Z},
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 abstract = {A heterotelechelic poly(norbornene imide) containing two terminal and
orthogonal hydrogen-bonding receptors,
N,N'-bis[6-(alkanoylamino)pyridin-2-yl] isophthalamide (often referred
to as the Hamilton receptor or Wedge) and 2,7-diamido-1,8-naphthyridine
(DAN), at the opposite ends of the polymer was synthesized via
ring-opening metathesis polymerization (ROMP) through the employment of
a Hamilton receptor-functionalized ruthenium initiator and a DAN-based
chain-terminator. In parallel, two monotelechelic polymers containing
either cyanuric acid (CA)- or ureidoguanosine (UG)-end groups that are
complementary to the hydrogen-bonding receptors along the
poly(norbornene imide) were synthesized either also via ROMP by
terminating the polymerization of norbornene octyl ester with a CA-based
chain-terminator or by the reaction of poly(ethylene oxide) with UG.
Complete incorporations of the hydrogen-bonding receptors at the
chain-ends of all polymers were confirmed by (1)H NMR spectroscopy. The
telechelic polymers can be self-assembled into ABC triblock copolymers
following either a stepwise or a one-pot, orthogonal self-assembly
protocol. The self-assembly process was monitored by (1)H NMR
spectroscopy, revealing full orthogonality of the two recognition pairs,
Hamilton receptor-CA and DAN-UG. The resulting supramolecular ABC
triblock copolymers were further characterized by a series of methods
including 2-D NOESY, isothermal titration calorimetry, and viscometry,
proving that the two orthogonal hydrogen-bonding interactions are strong
enough to hold the three polymer chains together. We suggest that a
self-assembly methodology solely based on the fully orthogonal
hydrogen-bonding recognition motifs will allow for an easy and rapid
synthesis of architecturally controlled supramolecular polymeric
assemblies with a high degree of complexity.},
 bibtype = {article},
 author = {Yang, Si Kyung and Ambade, Ashootosh V and Weck, Marcus},
 journal = {JOURNAL OF THE AMERICAN CHEMICAL SOCIETY},
 number = {5}
}

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