@article{yang_genome-wide_2015,
	title = {Genome-{Wide} {Association} {Analysis} for {Blood} {Lipid} {Traits} {Measured} in {Three} {Pig} {Populations} {Reveals} a {Substantial} {Level} of {Genetic} {Heterogeneity}},
	volume = {10},
	issn = {1932-6203},
	url = {https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131667},
	doi = {10.1371/journal.pone.0131667},
	abstract = {Serum lipids are associated with myocardial infarction and cardiovascular disease in humans. Here we dissected the genetic architecture of blood lipid traits by applying genome-wide association studies (GWAS) in 1,256 pigs from Laiwu, Erhualian and Duroc × (Landrace × Yorkshire) populations, and a meta-analysis of GWAS in more than 2,400 pigs from five diverse populations. A total of 22 genomic loci surpassing the suggestive significance level were detected on 11 pig chromosomes (SSC) for six blood lipid traits. Meta-analysis of GWAS identified 5 novel loci associated with blood lipid traits. Comparison of GWAS loci across the tested populations revealed a substantial level of genetic heterogeneity for porcine blood lipid levels. We further evaluated the causality of nine polymorphisms nearby or within the APOB gene on SSC3 for serum LDL-C and TC levels. Of the 9 polymorphisms, an indel showed the most significant association with LDL-C and TC in Laiwu pigs. But the significant association was not identified in the White Duroc × Erhualian F2 resource population, in which the QTL for LDL-C and TC was also detected on SSC3. This indicates that population-specific signals may exist for the SSC3 QTL. Further investigations are warranted to validate this assumption.},
	language = {en},
	number = {6},
	urldate = {2022-09-20},
	journal = {PLOS ONE},
	author = {Yang, Hui and Huang, Xiaochang and Zeng, Zhijun and Zhang, Wanchang and Liu, Chenlong and Fang, Shaoming and Huang, Lusheng and Chen, Congying},
	month = jun,
	year = {2015},
	note = {Publisher: Public Library of Science},
	keywords = {Blood, Genetic loci, Genome-wide association studies, Genomics, Lipids, Metaanalysis, Single nucleotide polymorphisms, Swine},
	pages = {e0131667},
}

{"_id":"usm8hgA3Hcq8qEh3r","bibbaseid":"yang-huang-zeng-zhang-liu-fang-huang-chen-genomewideassociationanalysisforbloodlipidtraitsmeasuredinthreepigpopulationsrevealsasubstantiallevelofgeneticheterogeneity-2015","author_short":["Yang, H.","Huang, X.","Zeng, Z.","Zhang, W.","Liu, C.","Fang, S.","Huang, L.","Chen, C."],"bibdata":{"bibtype":"article","type":"article","title":"Genome-Wide Association Analysis for Blood Lipid Traits Measured in Three Pig Populations Reveals a Substantial Level of Genetic Heterogeneity","volume":"10","issn":"1932-6203","url":"https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131667","doi":"10.1371/journal.pone.0131667","abstract":"Serum lipids are associated with myocardial infarction and cardiovascular disease in humans. Here we dissected the genetic architecture of blood lipid traits by applying genome-wide association studies (GWAS) in 1,256 pigs from Laiwu, Erhualian and Duroc × (Landrace × Yorkshire) populations, and a meta-analysis of GWAS in more than 2,400 pigs from five diverse populations. A total of 22 genomic loci surpassing the suggestive significance level were detected on 11 pig chromosomes (SSC) for six blood lipid traits. Meta-analysis of GWAS identified 5 novel loci associated with blood lipid traits. Comparison of GWAS loci across the tested populations revealed a substantial level of genetic heterogeneity for porcine blood lipid levels. We further evaluated the causality of nine polymorphisms nearby or within the APOB gene on SSC3 for serum LDL-C and TC levels. Of the 9 polymorphisms, an indel showed the most significant association with LDL-C and TC in Laiwu pigs. But the significant association was not identified in the White Duroc × Erhualian F2 resource population, in which the QTL for LDL-C and TC was also detected on SSC3. This indicates that population-specific signals may exist for the SSC3 QTL. Further investigations are warranted to validate this assumption.","language":"en","number":"6","urldate":"2022-09-20","journal":"PLOS ONE","author":[{"propositions":[],"lastnames":["Yang"],"firstnames":["Hui"],"suffixes":[]},{"propositions":[],"lastnames":["Huang"],"firstnames":["Xiaochang"],"suffixes":[]},{"propositions":[],"lastnames":["Zeng"],"firstnames":["Zhijun"],"suffixes":[]},{"propositions":[],"lastnames":["Zhang"],"firstnames":["Wanchang"],"suffixes":[]},{"propositions":[],"lastnames":["Liu"],"firstnames":["Chenlong"],"suffixes":[]},{"propositions":[],"lastnames":["Fang"],"firstnames":["Shaoming"],"suffixes":[]},{"propositions":[],"lastnames":["Huang"],"firstnames":["Lusheng"],"suffixes":[]},{"propositions":[],"lastnames":["Chen"],"firstnames":["Congying"],"suffixes":[]}],"month":"June","year":"2015","note":"Publisher: Public Library of Science","keywords":"Blood, Genetic loci, Genome-wide association studies, Genomics, Lipids, Metaanalysis, Single nucleotide polymorphisms, Swine","pages":"e0131667","bibtex":"@article{yang_genome-wide_2015,\n\ttitle = {Genome-{Wide} {Association} {Analysis} for {Blood} {Lipid} {Traits} {Measured} in {Three} {Pig} {Populations} {Reveals} a {Substantial} {Level} of {Genetic} {Heterogeneity}},\n\tvolume = {10},\n\tissn = {1932-6203},\n\turl = {https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131667},\n\tdoi = {10.1371/journal.pone.0131667},\n\tabstract = {Serum lipids are associated with myocardial infarction and cardiovascular disease in humans. Here we dissected the genetic architecture of blood lipid traits by applying genome-wide association studies (GWAS) in 1,256 pigs from Laiwu, Erhualian and Duroc × (Landrace × Yorkshire) populations, and a meta-analysis of GWAS in more than 2,400 pigs from five diverse populations. A total of 22 genomic loci surpassing the suggestive significance level were detected on 11 pig chromosomes (SSC) for six blood lipid traits. Meta-analysis of GWAS identified 5 novel loci associated with blood lipid traits. Comparison of GWAS loci across the tested populations revealed a substantial level of genetic heterogeneity for porcine blood lipid levels. We further evaluated the causality of nine polymorphisms nearby or within the APOB gene on SSC3 for serum LDL-C and TC levels. Of the 9 polymorphisms, an indel showed the most significant association with LDL-C and TC in Laiwu pigs. But the significant association was not identified in the White Duroc × Erhualian F2 resource population, in which the QTL for LDL-C and TC was also detected on SSC3. This indicates that population-specific signals may exist for the SSC3 QTL. Further investigations are warranted to validate this assumption.},\n\tlanguage = {en},\n\tnumber = {6},\n\turldate = {2022-09-20},\n\tjournal = {PLOS ONE},\n\tauthor = {Yang, Hui and Huang, Xiaochang and Zeng, Zhijun and Zhang, Wanchang and Liu, Chenlong and Fang, Shaoming and Huang, Lusheng and Chen, Congying},\n\tmonth = jun,\n\tyear = {2015},\n\tnote = {Publisher: Public Library of Science},\n\tkeywords = {Blood, Genetic loci, Genome-wide association studies, Genomics, Lipids, Metaanalysis, Single nucleotide polymorphisms, Swine},\n\tpages = {e0131667},\n}\n\n\n\n\n\n\n\n\n\n\n\n","author_short":["Yang, H.","Huang, X.","Zeng, Z.","Zhang, W.","Liu, C.","Fang, S.","Huang, L.","Chen, C."],"key":"yang_genome-wide_2015","id":"yang_genome-wide_2015","bibbaseid":"yang-huang-zeng-zhang-liu-fang-huang-chen-genomewideassociationanalysisforbloodlipidtraitsmeasuredinthreepigpopulationsrevealsasubstantiallevelofgeneticheterogeneity-2015","role":"author","urls":{"Paper":"https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131667"},"keyword":["Blood","Genetic loci","Genome-wide association studies","Genomics","Lipids","Metaanalysis","Single nucleotide polymorphisms","Swine"],"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://bibbase.org/zotero/chiraaggohel","dataSources":["akApyGuSiBYkDccny"],"keywords":["blood","genetic loci","genome-wide association studies","genomics","lipids","metaanalysis","single nucleotide polymorphisms","swine"],"search_terms":["genome","wide","association","analysis","blood","lipid","traits","measured","three","pig","populations","reveals","substantial","level","genetic","heterogeneity","yang","huang","zeng","zhang","liu","fang","huang","chen"],"title":"Genome-Wide Association Analysis for Blood Lipid Traits Measured in Three Pig Populations Reveals a Substantial Level of Genetic Heterogeneity","year":2015}