@article{
 title = {Generation of a transgenic rice seed-based edible vaccine against house dust mite allergy},
 type = {article},
 year = {2008},
 keywords = {Allergens},
 pages = {334-339},
 volume = {365},
 id = {7facccc5-e0cd-340e-8d3c-d3150f58af86},
 created = {2012-01-05T13:10:01.000Z},
 file_attached = {false},
 profile_id = {1a467167-0a41-3583-a6a3-034c31031332},
 group_id = {0e532975-1a47-38a4-ace8-4fe5968bcd72},
 last_modified = {2012-01-05T13:15:19.000Z},
 tags = {GMO Applications},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {Journal Article},
 abstract = {As an alternative approach to conventional allergen-specific immunotherapy, transgenic rice seed expressing a major house dust mite (HDM) allergen, Der p 1, was developed as an edible vaccine. The C-terminal KDEL-tagged Der p 1 allergen specifically accumulated in seed endosperm tissue under the control of the endosperm-specific GluB1 promoter. Der p 1 reached a maximum concentration of 58 μg/grain and was deposited in the endoplasmic reticulum (ER)-derived protein body I (PB-I). Plant-derived Der p 1 was posttranslationally modified with high-mannose-type glycan structures. Glycosylated Der p 1 displayed reduced IgE binding capacity in comparison with its unglycosylated counterpart in vitro. Our results indicate that transgenic Der p 1 rice seeds are a safe, potential oral delivery vaccine for the treatment of HDM allergy.  },
 bibtype = {article},
 author = {Yang, Lijun and Kajiura, Hiroyuki and Suzuki, Kazuya and Kirose, Sakiko and Fukiyama, Kazuhito and Takaiwa, Fumio},
 journal = {Biochemical and Biophysical Research Communications},
 number = {2}
}

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