@article{
 id = {269466e0-9771-322a-a444-f4b7d6ee6f05},
 title = {A tidally breathing model of ventilation, perfusion and volume in normal and diseased lungs.},
 type = {article},
 year = {2006},
 identifiers = {[object Object]},
 keywords = {Adult,Breath Tests,Humans,Male,Models, Biological,Pulmonary Alveoli,Pulmonary Alveoli: physiopathology,Pulmonary Embolism,Pulmonary Embolism: physiopathology,Pulmonary Emphysema,Pulmonary Emphysema: physiopathology,Pulmonary Gas Exchange,Solubility,Ventilation-Perfusion Ratio},
 created = {2009-07-23T22:41:39.000Z},
 pages = {718-31},
 volume = {97},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/16926169},
 file_attached = {true},
 profile_id = {fe7067eb-58b8-34c6-b8cd-6717fdf7605c},
 group_id = {f87494e7-529d-3e68-b1f1-0e6d57d138db},
 last_modified = {2014-07-19T19:15:34.000Z},
 read = {true},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Yem2006a},
 short_title = {Br J Anaesth},
 client_data = {"desktop_id":"eda56111-169a-4567-9a5a-d2dc8e644a27"},
 abstract = {BACKGROUND: To simulate the short-term dynamics of soluble gas exchange (e.g. CO2 rebreathing), model structure, ventilation-perfusion (VA/Q) and ventilation-volume (VA/VA) parameters must be selected correctly. Some diseases affect mainly the VA/Q distribution while others affect both VA/Q and VA/VA distributions. Results from the multiple inert gas elimination technique (MIGET) and multiple breath nitrogen washout (MBNW) can be used to select VA/Q and VA/VA parameters, but no method exists for combining VA/Q and VA/VA parameters in a multicompartment lung model. METHODS: We define a tidally breathing lung model containing shunt and up to eight alveolar compartments. Quantitative and qualitative understanding of the diseases is used to reduce the number of model compartments to achieve a unique solution. The reduced model is fitted simultaneously to inert gas retentions calculated from published VA/Q distributions and normalized MBNWs obtained from similar subjects. Normal lungs and representative cases of emphysema and embolism are studied. RESULTS: The normal, emphysematous and embolism models simplify to one, three and two alveolar compartments, respectively. CONCLUSIONS: The models reproduce their respective MIGET and MBNW patient results well, and predict disease-specific steady-state and dynamic soluble and insoluble gas responses.},
 bibtype = {article},
 author = {Yem, J S and Turner, M J and Baker, a B and Young, I H and Crawford, a B H},
 journal = {British journal of anaesthesia},
 number = {5}
}

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Some diseases affect mainly the VA/Q distribution while others affect both VA/Q and VA/VA distributions. Results from the multiple inert gas elimination technique (MIGET) and multiple breath nitrogen washout (MBNW) can be used to select VA/Q and VA/VA parameters, but no method exists for combining VA/Q and VA/VA parameters in a multicompartment lung model. METHODS: We define a tidally breathing lung model containing shunt and up to eight alveolar compartments. Quantitative and qualitative understanding of the diseases is used to reduce the number of model compartments to achieve a unique solution. The reduced model is fitted simultaneously to inert gas retentions calculated from published VA/Q distributions and normalized MBNWs obtained from similar subjects. Normal lungs and representative cases of emphysema and embolism are studied. RESULTS: The normal, emphysematous and embolism models simplify to one, three and two alveolar compartments, respectively. CONCLUSIONS: The models reproduce their respective MIGET and MBNW patient results well, and predict disease-specific steady-state and dynamic soluble and insoluble gas responses.","bibtype":"article","author":"Yem, J S and Turner, M J and Baker, a B and Young, I H and Crawford, a B H","journal":"British journal of anaesthesia","number":"5","bibtex":"@article{\n id = {269466e0-9771-322a-a444-f4b7d6ee6f05},\n title = {A tidally breathing model of ventilation, perfusion and volume in normal and diseased lungs.},\n type = {article},\n year = {2006},\n identifiers = {[object Object]},\n keywords = {Adult,Breath Tests,Humans,Male,Models, Biological,Pulmonary Alveoli,Pulmonary Alveoli: physiopathology,Pulmonary Embolism,Pulmonary Embolism: physiopathology,Pulmonary Emphysema,Pulmonary Emphysema: physiopathology,Pulmonary Gas Exchange,Solubility,Ventilation-Perfusion Ratio},\n created = {2009-07-23T22:41:39.000Z},\n pages = {718-31},\n volume = {97},\n websites = {http://www.ncbi.nlm.nih.gov/pubmed/16926169},\n file_attached = {true},\n profile_id = {fe7067eb-58b8-34c6-b8cd-6717fdf7605c},\n group_id = {f87494e7-529d-3e68-b1f1-0e6d57d138db},\n last_modified = {2014-07-19T19:15:34.000Z},\n read = {true},\n starred = {false},\n authored = {false},\n confirmed = {true},\n hidden = {false},\n citation_key = {Yem2006a},\n short_title = {Br J Anaesth},\n client_data = {\"desktop_id\":\"eda56111-169a-4567-9a5a-d2dc8e644a27\"},\n abstract = {BACKGROUND: To simulate the short-term dynamics of soluble gas exchange (e.g. CO2 rebreathing), model structure, ventilation-perfusion (VA/Q) and ventilation-volume (VA/VA) parameters must be selected correctly. 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