@article{
 title = {It's all in the timing Modeling isovolumic contraction through development and disease with a dynamic dual electromechanical bioreactor system},
 type = {article},
 year = {2014},
 identifiers = {[object Object]},
 keywords = {Cardiac tissue engineering,Contraction force,Electromechanical stimulation,Isovolumic contraction time},
 volume = {10},
 id = {ef40c781-9960-3311-8551-6c431cb63d5e},
 created = {2017-08-16T18:09:15.307Z},
 file_attached = {false},
 profile_id = {25eaa2aa-8159-328a-a13c-126593de9b73},
 last_modified = {2017-08-16T18:09:15.307Z},
 read = {false},
 starred = {false},
 authored = {true},
 confirmed = {false},
 hidden = {false},
 abstract = {© 2014 Taylor  &  Francis Group, LLC. This commentary discusses the rationale behind our recently reported work entitled "Mimicking isovolumic contraction with combined electromechanical stimulation improves the development of engineered cardiac constructs," introduces new data supporting our hypothesis, and discusses future applications of our bioreactor system. The ability to stimulate engineered cardiac tissue in a bioreactor system that combines both electrical and mechanical stimulation offers a unique opportunity to simulate the appropriate dynamics between stretch and contraction and model isovolumic contraction in vitro. Our previous study demonstrated that combined electromechanical stimulation that simulated the timing of isovolumic contraction in healthy tissue improved force generation via increased contractile and calcium handling protein expression and improved hypertrophic pathway activation. In new data presented here, we further demonstrate that modification of the timing between electrical and mechanical stimulation to mimic a non-physiological process negatively impacts the functionality of the engineered constructs. We close by exploring the various disease states that have altered timing between the electrical and mechanical stimulation signals as potential future directions for the use of this system.},
 bibtype = {article},
 author = {Ye Morgan, K. and Black, L.D.},
 journal = {Organogenesis},
 number = {3}
}

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This commentary discusses the rationale behind our recently reported work entitled \"Mimicking isovolumic contraction with combined electromechanical stimulation improves the development of engineered cardiac constructs,\" introduces new data supporting our hypothesis, and discusses future applications of our bioreactor system. The ability to stimulate engineered cardiac tissue in a bioreactor system that combines both electrical and mechanical stimulation offers a unique opportunity to simulate the appropriate dynamics between stretch and contraction and model isovolumic contraction in vitro. Our previous study demonstrated that combined electromechanical stimulation that simulated the timing of isovolumic contraction in healthy tissue improved force generation via increased contractile and calcium handling protein expression and improved hypertrophic pathway activation. In new data presented here, we further demonstrate that modification of the timing between electrical and mechanical stimulation to mimic a non-physiological process negatively impacts the functionality of the engineered constructs. We close by exploring the various disease states that have altered timing between the electrical and mechanical stimulation signals as potential future directions for the use of this system.","bibtype":"article","author":"Ye Morgan, K. and Black, L.D.","journal":"Organogenesis","number":"3","bibtex":"@article{\n title = {It's all in the timing Modeling isovolumic contraction through development and disease with a dynamic dual electromechanical bioreactor system},\n type = {article},\n year = {2014},\n identifiers = {[object Object]},\n keywords = {Cardiac tissue engineering,Contraction force,Electromechanical stimulation,Isovolumic contraction time},\n volume = {10},\n id = {ef40c781-9960-3311-8551-6c431cb63d5e},\n created = {2017-08-16T18:09:15.307Z},\n file_attached = {false},\n profile_id = {25eaa2aa-8159-328a-a13c-126593de9b73},\n last_modified = {2017-08-16T18:09:15.307Z},\n read = {false},\n starred = {false},\n authored = {true},\n confirmed = {false},\n hidden = {false},\n abstract = {© 2014 Taylor & Francis Group, LLC. This commentary discusses the rationale behind our recently reported work entitled \"Mimicking isovolumic contraction with combined electromechanical stimulation improves the development of engineered cardiac constructs,\" introduces new data supporting our hypothesis, and discusses future applications of our bioreactor system. The ability to stimulate engineered cardiac tissue in a bioreactor system that combines both electrical and mechanical stimulation offers a unique opportunity to simulate the appropriate dynamics between stretch and contraction and model isovolumic contraction in vitro. Our previous study demonstrated that combined electromechanical stimulation that simulated the timing of isovolumic contraction in healthy tissue improved force generation via increased contractile and calcium handling protein expression and improved hypertrophic pathway activation. In new data presented here, we further demonstrate that modification of the timing between electrical and mechanical stimulation to mimic a non-physiological process negatively impacts the functionality of the engineered constructs. We close by exploring the various disease states that have altered timing between the electrical and mechanical stimulation signals as potential future directions for the use of this system.},\n bibtype = {article},\n author = {Ye Morgan, K. and Black, L.D.},\n journal = {Organogenesis},\n number = {3}\n}","author_short":["Ye Morgan, K.","Black, L."],"bibbaseid":"yemorgan-black-itsallinthetimingmodelingisovolumiccontractionthroughdevelopmentanddiseasewithadynamicdualelectromechanicalbioreactorsystem-2014","role":"author","urls":{},"keyword":["Cardiac tissue engineering","Contraction force","Electromechanical stimulation","Isovolumic contraction time"],"downloads":0},"search_terms":["timing","modeling","isovolumic","contraction","through","development","disease","dynamic","dual","electromechanical","bioreactor","system","ye morgan","black"],"keywords":["cardiac tissue engineering","contraction force","electromechanical stimulation","isovolumic contraction time"],"authorIDs":[]}