Trends in intussusception hospitalizations among US infants before and after implementation of the rotavirus vaccination program, 2000-2009. Yen, C., Tate, J. E., Steiner, C. A., Cortese, M. M., Patel, M. M., & Parashar, U. D. The Journal of Infectious Diseases, 206(1):41–48, July, 2012. doi abstract bibtex BACKGROUND: Although US data have not documented an intussusception risk with current rotavirus vaccines, international data indicate a possible low risk, primarily after the first dose. METHODS: Among infants in 26 US states comprising 75% of the birth cohort, we examined age-specific trends in population-level intussusception hospitalization rates before (2000-2005) and after (2007-2009) rotavirus vaccine introduction. RESULTS: Compared with 2000-2005 (35.3 per 100,000), the rate was greater in 2007 (39.0 per 100,000; rate ratio [RR], 1.10; 95% confidence interval [CI], 1.04-1.18), similar in 2008 (33.4 per 100,000; RR, 0.95; 95% CI, .89-1.01), and lower in 2009 (32.9 per 100,000; RR, 0.93; 95% CI, .87-.99). Among infants aged 8-11 weeks, compared with 2000-2005 (6.9 per 100,000), a small, significant increase was observed in each of 2007 (11.4 per 100,000; RR, 1.64; 95% CI, 1.08-2.50), 2008 (12.2 per 100,000; RR, 1.76; 95% CI, 1.17-2.65), and 2009 (11.0 per 100,000; RR, 1.59; 95% CI, 1.04-2.44). CONCLUSIONS: Following rotavirus vaccine introduction, a small increase in intussusception rates was seen among US infants aged 8-11 weeks, to whom most first doses of vaccine are given; no sustained population-level change in overall rates was observed.
@article{yen_trends_2012,
title = {Trends in intussusception hospitalizations among {US} infants before and after implementation of the rotavirus vaccination program, 2000-2009},
volume = {206},
issn = {1537-6613},
doi = {10.1093/infdis/jis314},
abstract = {BACKGROUND: Although US data have not documented an intussusception risk with current rotavirus vaccines, international data indicate a possible low risk, primarily after the first dose.
METHODS: Among infants in 26 US states comprising 75\% of the birth cohort, we examined age-specific trends in population-level intussusception hospitalization rates before (2000-2005) and after (2007-2009) rotavirus vaccine introduction.
RESULTS: Compared with 2000-2005 (35.3 per 100,000), the rate was greater in 2007 (39.0 per 100,000; rate ratio [RR], 1.10; 95\% confidence interval [CI], 1.04-1.18), similar in 2008 (33.4 per 100,000; RR, 0.95; 95\% CI, .89-1.01), and lower in 2009 (32.9 per 100,000; RR, 0.93; 95\% CI, .87-.99). Among infants aged 8-11 weeks, compared with 2000-2005 (6.9 per 100,000), a small, significant increase was observed in each of 2007 (11.4 per 100,000; RR, 1.64; 95\% CI, 1.08-2.50), 2008 (12.2 per 100,000; RR, 1.76; 95\% CI, 1.17-2.65), and 2009 (11.0 per 100,000; RR, 1.59; 95\% CI, 1.04-2.44).
CONCLUSIONS: Following rotavirus vaccine introduction, a small increase in intussusception rates was seen among US infants aged 8-11 weeks, to whom most first doses of vaccine are given; no sustained population-level change in overall rates was observed.},
language = {eng},
number = {1},
journal = {The Journal of Infectious Diseases},
author = {Yen, Catherine and Tate, Jacqueline E. and Steiner, Claudia A. and Cortese, Margaret M. and Patel, Manish M. and Parashar, Umesh D.},
month = jul,
year = {2012},
pmid = {22539812},
keywords = {Age Factors, Cohort Studies, Confidence Intervals, Hospitalization/trends, Humans, Infant, Intussusception/*epidemiology/immunology/virology, Rotavirus Infections/*epidemiology/immunology/prevention \& control, Rotavirus Vaccines/*administration \& dosage/adverse effects/immunology, Rotavirus/immunology, United States/epidemiology, Vaccination/methods},
pages = {41--48},
}
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{"_id":"3jA2vnp53sAvRbMRh","bibbaseid":"yen-tate-steiner-cortese-patel-parashar-trendsinintussusceptionhospitalizationsamongusinfantsbeforeandafterimplementationoftherotavirusvaccinationprogram20002009-2012","author_short":["Yen, C.","Tate, J. E.","Steiner, C. A.","Cortese, M. M.","Patel, M. M.","Parashar, U. D."],"bibdata":{"bibtype":"article","type":"article","title":"Trends in intussusception hospitalizations among US infants before and after implementation of the rotavirus vaccination program, 2000-2009","volume":"206","issn":"1537-6613","doi":"10.1093/infdis/jis314","abstract":"BACKGROUND: Although US data have not documented an intussusception risk with current rotavirus vaccines, international data indicate a possible low risk, primarily after the first dose. METHODS: Among infants in 26 US states comprising 75% of the birth cohort, we examined age-specific trends in population-level intussusception hospitalization rates before (2000-2005) and after (2007-2009) rotavirus vaccine introduction. RESULTS: Compared with 2000-2005 (35.3 per 100,000), the rate was greater in 2007 (39.0 per 100,000; rate ratio [RR], 1.10; 95% confidence interval [CI], 1.04-1.18), similar in 2008 (33.4 per 100,000; RR, 0.95; 95% CI, .89-1.01), and lower in 2009 (32.9 per 100,000; RR, 0.93; 95% CI, .87-.99). Among infants aged 8-11 weeks, compared with 2000-2005 (6.9 per 100,000), a small, significant increase was observed in each of 2007 (11.4 per 100,000; RR, 1.64; 95% CI, 1.08-2.50), 2008 (12.2 per 100,000; RR, 1.76; 95% CI, 1.17-2.65), and 2009 (11.0 per 100,000; RR, 1.59; 95% CI, 1.04-2.44). CONCLUSIONS: Following rotavirus vaccine introduction, a small increase in intussusception rates was seen among US infants aged 8-11 weeks, to whom most first doses of vaccine are given; no sustained population-level change in overall rates was observed.","language":"eng","number":"1","journal":"The Journal of Infectious Diseases","author":[{"propositions":[],"lastnames":["Yen"],"firstnames":["Catherine"],"suffixes":[]},{"propositions":[],"lastnames":["Tate"],"firstnames":["Jacqueline","E."],"suffixes":[]},{"propositions":[],"lastnames":["Steiner"],"firstnames":["Claudia","A."],"suffixes":[]},{"propositions":[],"lastnames":["Cortese"],"firstnames":["Margaret","M."],"suffixes":[]},{"propositions":[],"lastnames":["Patel"],"firstnames":["Manish","M."],"suffixes":[]},{"propositions":[],"lastnames":["Parashar"],"firstnames":["Umesh","D."],"suffixes":[]}],"month":"July","year":"2012","pmid":"22539812","keywords":"Age Factors, Cohort Studies, Confidence Intervals, Hospitalization/trends, Humans, Infant, Intussusception/*epidemiology/immunology/virology, Rotavirus Infections/*epidemiology/immunology/prevention & control, Rotavirus Vaccines/*administration & dosage/adverse effects/immunology, Rotavirus/immunology, United States/epidemiology, Vaccination/methods","pages":"41–48","bibtex":"@article{yen_trends_2012,\n\ttitle = {Trends in intussusception hospitalizations among {US} infants before and after implementation of the rotavirus vaccination program, 2000-2009},\n\tvolume = {206},\n\tissn = {1537-6613},\n\tdoi = {10.1093/infdis/jis314},\n\tabstract = {BACKGROUND: Although US data have not documented an intussusception risk with current rotavirus vaccines, international data indicate a possible low risk, primarily after the first dose.\nMETHODS: Among infants in 26 US states comprising 75\\% of the birth cohort, we examined age-specific trends in population-level intussusception hospitalization rates before (2000-2005) and after (2007-2009) rotavirus vaccine introduction.\nRESULTS: Compared with 2000-2005 (35.3 per 100,000), the rate was greater in 2007 (39.0 per 100,000; rate ratio [RR], 1.10; 95\\% confidence interval [CI], 1.04-1.18), similar in 2008 (33.4 per 100,000; RR, 0.95; 95\\% CI, .89-1.01), and lower in 2009 (32.9 per 100,000; RR, 0.93; 95\\% CI, .87-.99). Among infants aged 8-11 weeks, compared with 2000-2005 (6.9 per 100,000), a small, significant increase was observed in each of 2007 (11.4 per 100,000; RR, 1.64; 95\\% CI, 1.08-2.50), 2008 (12.2 per 100,000; RR, 1.76; 95\\% CI, 1.17-2.65), and 2009 (11.0 per 100,000; RR, 1.59; 95\\% CI, 1.04-2.44).\nCONCLUSIONS: Following rotavirus vaccine introduction, a small increase in intussusception rates was seen among US infants aged 8-11 weeks, to whom most first doses of vaccine are given; no sustained population-level change in overall rates was observed.},\n\tlanguage = {eng},\n\tnumber = {1},\n\tjournal = {The Journal of Infectious Diseases},\n\tauthor = {Yen, Catherine and Tate, Jacqueline E. and Steiner, Claudia A. and Cortese, Margaret M. and Patel, Manish M. and Parashar, Umesh D.},\n\tmonth = jul,\n\tyear = {2012},\n\tpmid = {22539812},\n\tkeywords = {Age Factors, Cohort Studies, Confidence Intervals, Hospitalization/trends, Humans, Infant, Intussusception/*epidemiology/immunology/virology, Rotavirus Infections/*epidemiology/immunology/prevention \\& control, Rotavirus Vaccines/*administration \\& dosage/adverse effects/immunology, Rotavirus/immunology, United States/epidemiology, Vaccination/methods},\n\tpages = {41--48},\n}\n\n","author_short":["Yen, C.","Tate, J. 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