@article{yew_metformin_2019,
	title = {Metformin as a host-directed therapeutic in tuberculosis: {Is} there a promise?},
	volume = {115},
	issn = {1873-281X},
	shorttitle = {Metformin as a host-directed therapeutic in tuberculosis},
	doi = {10.1016/j.tube.2019.02.004},
	abstract = {To complement the development of new or repurposed drugs for improving the treatment outcomes of drug-susceptible and drug-resistant tuberculosis, current insight also focuses on the use of host-directed therapy. Metformin, a drug often used in the management of type 2 diabetes mellitus, has attracted attention by virtue of its favourable activity as an adjunctive agent against tuberculosis, discovered through laboratory and clinical studies. To definitively establish its role as a host-directed therapeutic in tuberculosis, more preclinical and clinical research is still required to better delineate its mechanism(s) of action and optimal clinical use.},
	language = {eng},
	journal = {Tuberculosis (Edinburgh, Scotland)},
	author = {Yew, Wing Wai and Chang, Kwok Chiu and Chan, Denise P. and Zhang, Ying},
	month = mar,
	year = {2019},
	pmid = {30948180},
	keywords = {Animals, Antitubercular Agents, Autophagy, Drug Interactions, Drug Therapy, Combination, Forecasting, Host-Pathogen Interactions, Humans, Immunity, Cellular, Latent Tuberculosis, Macrophages, Metformin, Mice, Mycobacterium tuberculosis, Oxidative Stress, Tuberculosis},
	pages = {76--80},
}

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