Intussusception Risk after Rotavirus Vaccination in U.S. Infants. Yih, W. K., Lieu, T. A., Kulldorff, M., Martin, D., McMahill-Walraven, C. N., Platt, R., Selvam, N., Selvan, M., Lee, G. M., & Nguyen, M. New England Journal of Medicine, 370(6):503–512, 2014.
Paper doi abstract bibtex In 1999, a tetravalent rhesus–human reassortant rotavirus vaccine (RotaShield, Wyeth Lederle) was voluntarily withdrawn from the U.S. market within a year after licensure owing to an association with intussusception. The excess risk of intussusception was estimated at approximately 1 to 2 cases per 10,000 recipients of the vaccine.1 In 2006 and 2008, respectively, a pentavalent bovine–human reassortant rotavirus vaccine (RV5; RotaTeq, Merck) and a monovalent human rotavirus vaccine (RV1; Rotarix, GlaxoSmithKline) were licensed after evaluation in clinical trials involving more than 60,000 infants, which provided enough statistical power to allow detection of an intussusception risk of a magnitude similar to . . .
@article{yih_intussusception_2014,
title = {Intussusception {Risk} after {Rotavirus} {Vaccination} in {U}.{S}. {Infants}},
volume = {370},
issn = {0028-4793},
url = {http://www.nejm.org/doi/full/10.1056/NEJMoa1303164},
doi = {10.1056/NEJMoa1303164},
abstract = {In 1999, a tetravalent rhesus–human reassortant rotavirus vaccine (RotaShield, Wyeth Lederle) was voluntarily withdrawn from the U.S. market within a year after licensure owing to an association with intussusception. The excess risk of intussusception was estimated at approximately 1 to 2 cases per 10,000 recipients of the vaccine.1 In 2006 and 2008, respectively, a pentavalent bovine–human reassortant rotavirus vaccine (RV5; RotaTeq, Merck) and a monovalent human rotavirus vaccine (RV1; Rotarix, GlaxoSmithKline) were licensed after evaluation in clinical trials involving more than 60,000 infants, which provided enough statistical power to allow detection of an intussusception risk of a magnitude similar to . . .},
number = {6},
urldate = {2014-07-29},
journal = {New England Journal of Medicine},
author = {Yih, W. Katherine and Lieu, Tracy A. and Kulldorff, Martin and Martin, David and McMahill-Walraven, Cheryl N. and Platt, Richard and Selvam, Nandini and Selvan, Mano and Lee, Grace M. and Nguyen, Michael},
year = {2014},
pmid = {24422676},
keywords = {\#duplicates, Cohort Studies, Humans, Immunization, Secondary, Infant, Intussusception/epidemiology/*etiology, Rotavirus Vaccines/administration \& dosage/*adverse effects, United States/epidemiology, Vaccines, Attenuated/administration \& dosage/adverse effects, risk},
pages = {503--512},
}
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The excess risk of intussusception was estimated at approximately 1 to 2 cases per 10,000 recipients of the vaccine.1 In 2006 and 2008, respectively, a pentavalent bovine–human reassortant rotavirus vaccine (RV5; RotaTeq, Merck) and a monovalent human rotavirus vaccine (RV1; Rotarix, GlaxoSmithKline) were licensed after evaluation in clinical trials involving more than 60,000 infants, which provided enough statistical power to allow detection of an intussusception risk of a magnitude similar to . . .},\n\tnumber = {6},\n\turldate = {2014-07-29},\n\tjournal = {New England Journal of Medicine},\n\tauthor = {Yih, W. 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