Ubiquitin Lysine 63 Chain–Forming Ligases Regulate Apical Dominance in Arabidopsis

Ubiquitin Lysine 63 Chain–Forming Ligases Regulate Apical Dominance in Arabidopsis. Yin, X., Volk, S., Ljung, K., Mehlmer, N., Dolezal, K., Ditengou, F., Hanano, S., Davis, S. J., Schmelzer, E., Sandberg, G., Teige, M., Palme, K., Pickart, C., & Bachmair, A. The Plant Cell, 19(6):1898–1911, July, 2007.

Paper doi abstract bibtex

Abstract Lys-63–linked multiubiquitin chains play important roles in signal transduction in yeast and in mammals, but the functions for this type of chain in plants remain to be defined. The RING domain protein RGLG2 (for RING domain Ligase2) from Arabidopsis thaliana can be N-terminally myristoylated and localizes to the plasma membrane. It can form Lys-63–linked multiubiquitin chains in an in vitro reaction. RGLG2 has overlapping functions with its closest sequelog, RGLG1, and single mutants in either gene are inconspicuous. rglg1 rglg2 double mutant plants exhibit loss of apical dominance and altered phyllotaxy, two traits critically influenced by the plant hormone auxin. Auxin and cytokinin levels are changed, and the plants show a decreased response to exogenously added auxin. Changes in the abundance of PIN family auxin transport proteins and synthetic lethality with a mutation in the auxin transport regulator BIG suggest that the directional flow of auxin is modulated by RGLG activity. Modification of proteins by Lys-63–linked multiubiquitin chains is thus important for hormone-regulated, basic plant architecture.

@article{yin_ubiquitin_2007,
	title = {Ubiquitin {Lysine} 63 {Chain}–{Forming} {Ligases} {Regulate} {Apical} {Dominance} in \textit{{Arabidopsis}}},
	volume = {19},
	issn = {1532-298X},
	url = {https://academic.oup.com/plcell/article/19/6/1898/6092124},
	doi = {10/cwwcnr},
	abstract = {Abstract
            Lys-63–linked multiubiquitin chains play important roles in signal transduction in yeast and in mammals, but the functions for this type of chain in plants remain to be defined. The RING domain protein RGLG2 (for RING domain Ligase2) from Arabidopsis thaliana can be N-terminally myristoylated and localizes to the plasma membrane. It can form Lys-63–linked multiubiquitin chains in an in vitro reaction. RGLG2 has overlapping functions with its closest sequelog, RGLG1, and single mutants in either gene are inconspicuous. rglg1 rglg2 double mutant plants exhibit loss of apical dominance and altered phyllotaxy, two traits critically influenced by the plant hormone auxin. Auxin and cytokinin levels are changed, and the plants show a decreased response to exogenously added auxin. Changes in the abundance of PIN family auxin transport proteins and synthetic lethality with a mutation in the auxin transport regulator BIG suggest that the directional flow of auxin is modulated by RGLG activity. Modification of proteins by Lys-63–linked multiubiquitin chains is thus important for hormone-regulated, basic plant architecture.},
	language = {en},
	number = {6},
	urldate = {2021-06-10},
	journal = {The Plant Cell},
	author = {Yin, Xiao-Jun and Volk, Sara and Ljung, Karin and Mehlmer, Norbert and Dolezal, Karel and Ditengou, Franck and Hanano, Shigeru and Davis, Seth J. and Schmelzer, Elmon and Sandberg, Göran and Teige, Markus and Palme, Klaus and Pickart, Cecile and Bachmair, Andreas},
	month = jul,
	year = {2007},
	pages = {1898--1911},
}

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