@ARTICLE{Yissachar2013-cu,
  title     = "Dynamic response diversity of {NFAT} isoforms in individual
               living cells",
  author    = "Yissachar, Nissan and Sharar Fischler, Tali and Cohen, Ariel A
               and Reich-Zeliger, Shlomit and Russ, Dor and Shifrut, Eric and
               Porat, Ziv and Friedman, Nir",
  abstract  = "Processing of external information by mammalian cells often
               involves seemingly redundant isoforms of signaling molecules and
               transcription factors. Understanding the functional relevance of
               coexpressed isoforms that respond to the same signal and control
               a shared set of genes is still limited. Here we show, using
               imaging of individual living mammalian cells, that the closely
               related transcription factors NFAT1 and NFAT4 possess distinct
               nuclear localization dynamics in response to cell stimulation.
               NFAT4 shows a fast response, with rapid stochastic bursts of
               nuclear localization. Burst frequency grows with signal level,
               while response amplitude is fixed. In contrast, NFAT1 has a
               slow, continuous response, and its amplitude increases with
               signal level. These diverse dynamical features observed for
               single cells are translated into different impulse response
               strategies at the cell population level. We suggest that dynamic
               response diversity of seemingly redundant genes can provide
               cells with enhanced capabilities of temporal information
               processing.",
  journal   = "Mol. Cell",
  publisher = "Elsevier BV",
  volume    =  49,
  number    =  2,
  pages     = "322--330",
  month     =  jan,
  year      =  2013,
  copyright = "http://www.elsevier.com/open-access/userlicense/1.0/",
  language  = "en"
}

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A","Reich-Zeliger, S.","Russ, D.","Shifrut, E.","Porat, Z.","Friedman, N."],"bibdata":{"bibtype":"article","type":"article","title":"Dynamic response diversity of NFAT isoforms in individual living cells","author":[{"propositions":[],"lastnames":["Yissachar"],"firstnames":["Nissan"],"suffixes":[]},{"propositions":[],"lastnames":["Sharar","Fischler"],"firstnames":["Tali"],"suffixes":[]},{"propositions":[],"lastnames":["Cohen"],"firstnames":["Ariel","A"],"suffixes":[]},{"propositions":[],"lastnames":["Reich-Zeliger"],"firstnames":["Shlomit"],"suffixes":[]},{"propositions":[],"lastnames":["Russ"],"firstnames":["Dor"],"suffixes":[]},{"propositions":[],"lastnames":["Shifrut"],"firstnames":["Eric"],"suffixes":[]},{"propositions":[],"lastnames":["Porat"],"firstnames":["Ziv"],"suffixes":[]},{"propositions":[],"lastnames":["Friedman"],"firstnames":["Nir"],"suffixes":[]}],"abstract":"Processing of external information by mammalian cells often involves seemingly redundant isoforms of signaling molecules and transcription factors. Understanding the functional relevance of coexpressed isoforms that respond to the same signal and control a shared set of genes is still limited. Here we show, using imaging of individual living mammalian cells, that the closely related transcription factors NFAT1 and NFAT4 possess distinct nuclear localization dynamics in response to cell stimulation. NFAT4 shows a fast response, with rapid stochastic bursts of nuclear localization. Burst frequency grows with signal level, while response amplitude is fixed. In contrast, NFAT1 has a slow, continuous response, and its amplitude increases with signal level. These diverse dynamical features observed for single cells are translated into different impulse response strategies at the cell population level. We suggest that dynamic response diversity of seemingly redundant genes can provide cells with enhanced capabilities of temporal information processing.","journal":"Mol. Cell","publisher":"Elsevier BV","volume":"49","number":"2","pages":"322–330","month":"January","year":"2013","copyright":"http://www.elsevier.com/open-access/userlicense/1.0/","language":"en","bibtex":"@ARTICLE{Yissachar2013-cu,\n title = \"Dynamic response diversity of {NFAT} isoforms in individual\n living cells\",\n author = \"Yissachar, Nissan and Sharar Fischler, Tali and Cohen, Ariel A\n and Reich-Zeliger, Shlomit and Russ, Dor and Shifrut, Eric and\n Porat, Ziv and Friedman, Nir\",\n abstract = \"Processing of external information by mammalian cells often\n involves seemingly redundant isoforms of signaling molecules and\n transcription factors. Understanding the functional relevance of\n coexpressed isoforms that respond to the same signal and control\n a shared set of genes is still limited. Here we show, using\n imaging of individual living mammalian cells, that the closely\n related transcription factors NFAT1 and NFAT4 possess distinct\n nuclear localization dynamics in response to cell stimulation.\n NFAT4 shows a fast response, with rapid stochastic bursts of\n nuclear localization. Burst frequency grows with signal level,\n while response amplitude is fixed. In contrast, NFAT1 has a\n slow, continuous response, and its amplitude increases with\n signal level. These diverse dynamical features observed for\n single cells are translated into different impulse response\n strategies at the cell population level. We suggest that dynamic\n response diversity of seemingly redundant genes can provide\n cells with enhanced capabilities of temporal information\n processing.\",\n journal = \"Mol. Cell\",\n publisher = \"Elsevier BV\",\n volume = 49,\n number = 2,\n pages = \"322--330\",\n month = jan,\n year = 2013,\n copyright = \"http://www.elsevier.com/open-access/userlicense/1.0/\",\n language = \"en\"\n}\n\n","author_short":["Yissachar, N.","Sharar Fischler, T.","Cohen, A. 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