@article{
 title = {Preparation and characterization of polyethylenimine-coated Fe3O4-MCM-48 nanocomposite particles as a novel agent for magnet-assisted transfection},
 type = {article},
 year = {2010},
 identifiers = {[object Object]},
 keywords = {dna delivery,efficiency,gene delivery,gene-therapy progress,in-vivo,iron-oxide,low-molecular-weight,magnetite,magnetofection,nanoparticles,nanoporous,nonviral vector,polyethyleneimine,prospects,toxicity},
 pages = {386-392},
 volume = {92A},
 websites = {<Go to ISI>://WOS:000272637000042},
 id = {5625bb4a-77e3-3c33-a7b8-7133736925a9},
 created = {2016-07-19T13:46:33.000Z},
 file_attached = {false},
 profile_id = {665883f5-c199-38de-9ab9-8da2850f5b5e},
 last_modified = {2016-07-19T13:46:57.000Z},
 read = {false},
 starred = {false},
 authored = {true},
 confirmed = {true},
 hidden = {false},
 source_type = {Journal Article},
 language = {English},
 notes = {ISI Document Delivery No.: 531BF<br/>Times Cited: 21<br/>Cited Reference Count: 34<br/>Yiu, Humphrey H. P. McBain, Stuart C. Lethbridge, Zoe A. D. Lees, Martin R. Dobson, Jon<br/>BBSRC [BBS/B/14523]; UK Cystic Fibrosis Trust; Royal Society Wolfson Research Merit Award<br/>Contract grant sponsor: BBSRC; contract grant number BBS/B/14523Contract grant sponsor: UK Cystic Fibrosis TrustJ.D. acknowledges the support of a Royal Society Wolfson Research Merit Award. H.H.P.Y. thanks Prof. Mamoun Mohammed and Dr. Muhammet Toprak (KTH, Stockholm) for HRTEM analysis.<br/>Wiley-blackwell<br/>Malden},
 abstract = {A new type of magnetic nanoparticle was synthesized using mesoporous silica MCM-48 as a template. Magnetite (Fe3O4) nanocrystals were incorporated onto the MCM-48 silica structure by thermal decomposition of iron(Ill) acetylacetonate. The particle size of these Fe3O4-MCM-48 composite particles is around 300 nm with an iron oxide content of ca. 20% w/w. Measurements from SQUID magnetometry suggest that these nanoparticles possess superparamagnetic properties similar to those of Fe3O4 nanoparticles. By coating positively charged polyethylenimine on to the surface, DNA can be bound onto the Fe3O4-MCM-48 nanoparticles. Transfection studies showed that these PEI-Fe3O4-MCM-48 particles were highly effective as a transfection reagent, and a 400% increase of transfection efficiency compared with the commercial products was recorded. (C) 2009 Wiley Periodicals, Inc. J Biomed Mater Res 92A: 386-392, 2010},
 bibtype = {article},
 author = {Yiu, H H P and McBain, S C and Lethbridge, Z A D and Lees, M R and Dobson, J},
 journal = {Journal of Biomedical Materials Research Part A},
 number = {1}
}

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