@article{
 title = {Neurons Are Recruited to a Memory Trace Based on Relative Neuronal Excitability Immediately before Training},
 type = {article},
 year = {2014},
 identifiers = {[object Object]},
 pages = {722-735},
 volume = {83},
 websites = {http://dx.doi.org/10.1016/j.neuron.2014.07.017},
 publisher = {Elsevier Inc.},
 id = {b190fc72-7a24-3194-bf41-eee8782eb4bc},
 created = {2015-08-27T20:41:36.000Z},
 file_attached = {true},
 profile_id = {d9838a1c-b610-3898-bad6-d5c9bde015b5},
 last_modified = {2018-05-23T00:04:21.736Z},
 read = {true},
 starred = {false},
 authored = {true},
 confirmed = {true},
 hidden = {false},
 citation_key = {Yiu2014},
 private_publication = {false},
 abstract = {Memories are thought to be sparsely encoded in neuronal networks, but little is known about why a given neuron is recruited or allocated to a particular memory trace. Previous research shows that in the lateral amygdala (LA), neurons with increased CREB are selectively recruited to a fear memory trace. CREB is a ubiquitous transcription factor implicated in many cellular processes. Which process mediates neuronal memory allocation? One hypothesis is that CREB increases neuronal excitability to bias neuronal recruitment, although this has not been shown experimentally. Here we use several methods to increase neuronal excitability and show this both biases recruitment into the memory trace and enhances memory formation. Moreover, artificial activation of these neurons alone is a sufficient retrieval cue for fear memory expression, showing that these neurons are critical components of the memory trace. These results indicate that neuronal memory allocation is based on relative neuronal excitability immediately before training. © 2014 Elsevier Inc.},
 bibtype = {article},
 author = {Yiu, Adelaide P. and Mercaldo, Valentina and Yan, Chen and Richards, Blake and Rashid, Asim J. and Hsiang, Hwa Lin Liz and Pressey, Jessica and Mahadevan, Vivek and Tran, Matthew M. and Kushner, Steven a. and Woodin, Melanie a. and Frankland, Paul W. and Josselyn, Sheena a.},
 journal = {Neuron},
 number = {3}
}

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