@article{yoh_prognostic_2014,
	title = {The prognostic significance of elevated levels of serum ferritin before chemotherapy in patients with non-{Hodgkin} lymphoma},
	volume = {14},
	issn = {2152-2669},
	doi = {10.1016/j.clml.2013.09.008},
	abstract = {BACKGROUND

Elevated levels of serum ferritin have been documented to be an adverse prognostic factor in patients with hematologic malignancies undergoing hematopoietic stem cell transplantation. The purpose of this study was to estimate the correlation between elevated levels of serum ferritin and survival outcomes in patients with non-Hodgkin lymphoma (NHL).


PATIENTS AND METHODS

A total of 267 patients who were newly diagnosed with NHL and who received chemotherapy between September 1999 and April 2012 were retrospectively analyzed.


RESULTS

In multivariate analysis, other chemotherapy regimens excluding CHOP-like chemotherapy regimens (cyclophosphamide, adriamycin, vincristine, prednisolone) and RCHOP (rituximab plus CHOP), a high level of β2-microglobulin, a high-intermediate/high risk according to the international prognostic index (IPI), and elevated levels of serum ferritin were all significant independent prognostic factors for 5-year progression-free survival rates. RCHOP and other chemotherapy regimens, a high level of β2-microglobulin, a high-intermediate/high IPI risk, and high levels of serum ferritin were significant independent prognostic factors for 5-year overall survival rates.


CONCLUSION

Elevated levels of serum ferritin of 500 ng/mL or more as well as the use of chemotherapy regimens besides CHOP-like or RCHOP, a high-intermediate/high risk IPI, and a high level of beta2-microglobulin in NHL may be an important marker for predicting poor survival outcomes.},
	number = {1},
	journal = {Clinical lymphoma, myeloma \& leukemia},
	author = {Yoh, Kyung Ah and Lee, Ho Sup and Park, Lee Chun and Lee, Eun Mi and Shin, Seong Hoon and Park, Dae Jin and Ye, Byeong Jin and Kim, Yang Soo},
	month = feb,
	year = {2014},
	pmid = {24200518},
	keywords = {Adolescent, Adult, Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols, Disease-Free Survival, Female, Ferritins, Humans, Lymphoma, Non-Hodgkin, Male, Middle Aged, Prognosis, Survival Rate},
	pages = {43--49}
}

{"_id":"qpffxcD6Fk5RBJXY2","bibbaseid":"yoh-lee-park-lee-shin-park-ye-kim-theprognosticsignificanceofelevatedlevelsofserumferritinbeforechemotherapyinpatientswithnonhodgkinlymphoma-2014","authorIDs":[],"author_short":["Yoh, K. A.","Lee, H. S.","Park, L. C.","Lee, E. M.","Shin, S. H.","Park, D. J.","Ye, B. J.","Kim, Y. S."],"bibdata":{"bibtype":"article","type":"article","title":"The prognostic significance of elevated levels of serum ferritin before chemotherapy in patients with non-Hodgkin lymphoma","volume":"14","issn":"2152-2669","doi":"10.1016/j.clml.2013.09.008","abstract":"BACKGROUND Elevated levels of serum ferritin have been documented to be an adverse prognostic factor in patients with hematologic malignancies undergoing hematopoietic stem cell transplantation. The purpose of this study was to estimate the correlation between elevated levels of serum ferritin and survival outcomes in patients with non-Hodgkin lymphoma (NHL). PATIENTS AND METHODS A total of 267 patients who were newly diagnosed with NHL and who received chemotherapy between September 1999 and April 2012 were retrospectively analyzed. RESULTS In multivariate analysis, other chemotherapy regimens excluding CHOP-like chemotherapy regimens (cyclophosphamide, adriamycin, vincristine, prednisolone) and RCHOP (rituximab plus CHOP), a high level of β2-microglobulin, a high-intermediate/high risk according to the international prognostic index (IPI), and elevated levels of serum ferritin were all significant independent prognostic factors for 5-year progression-free survival rates. RCHOP and other chemotherapy regimens, a high level of β2-microglobulin, a high-intermediate/high IPI risk, and high levels of serum ferritin were significant independent prognostic factors for 5-year overall survival rates. CONCLUSION Elevated levels of serum ferritin of 500 ng/mL or more as well as the use of chemotherapy regimens besides CHOP-like or RCHOP, a high-intermediate/high risk IPI, and a high level of beta2-microglobulin in NHL may be an important marker for predicting poor survival outcomes.","number":"1","journal":"Clinical lymphoma, myeloma & leukemia","author":[{"propositions":[],"lastnames":["Yoh"],"firstnames":["Kyung","Ah"],"suffixes":[]},{"propositions":[],"lastnames":["Lee"],"firstnames":["Ho","Sup"],"suffixes":[]},{"propositions":[],"lastnames":["Park"],"firstnames":["Lee","Chun"],"suffixes":[]},{"propositions":[],"lastnames":["Lee"],"firstnames":["Eun","Mi"],"suffixes":[]},{"propositions":[],"lastnames":["Shin"],"firstnames":["Seong","Hoon"],"suffixes":[]},{"propositions":[],"lastnames":["Park"],"firstnames":["Dae","Jin"],"suffixes":[]},{"propositions":[],"lastnames":["Ye"],"firstnames":["Byeong","Jin"],"suffixes":[]},{"propositions":[],"lastnames":["Kim"],"firstnames":["Yang","Soo"],"suffixes":[]}],"month":"February","year":"2014","pmid":"24200518","keywords":"Adolescent, Adult, Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols, Disease-Free Survival, Female, Ferritins, Humans, Lymphoma, Non-Hodgkin, Male, Middle Aged, Prognosis, Survival Rate","pages":"43–49","bibtex":"@article{yoh_prognostic_2014,\n\ttitle = {The prognostic significance of elevated levels of serum ferritin before chemotherapy in patients with non-{Hodgkin} lymphoma},\n\tvolume = {14},\n\tissn = {2152-2669},\n\tdoi = {10.1016/j.clml.2013.09.008},\n\tabstract = {BACKGROUND\n\nElevated levels of serum ferritin have been documented to be an adverse prognostic factor in patients with hematologic malignancies undergoing hematopoietic stem cell transplantation. The purpose of this study was to estimate the correlation between elevated levels of serum ferritin and survival outcomes in patients with non-Hodgkin lymphoma (NHL).\n\n\nPATIENTS AND METHODS\n\nA total of 267 patients who were newly diagnosed with NHL and who received chemotherapy between September 1999 and April 2012 were retrospectively analyzed.\n\n\nRESULTS\n\nIn multivariate analysis, other chemotherapy regimens excluding CHOP-like chemotherapy regimens (cyclophosphamide, adriamycin, vincristine, prednisolone) and RCHOP (rituximab plus CHOP), a high level of β2-microglobulin, a high-intermediate/high risk according to the international prognostic index (IPI), and elevated levels of serum ferritin were all significant independent prognostic factors for 5-year progression-free survival rates. RCHOP and other chemotherapy regimens, a high level of β2-microglobulin, a high-intermediate/high IPI risk, and high levels of serum ferritin were significant independent prognostic factors for 5-year overall survival rates.\n\n\nCONCLUSION\n\nElevated levels of serum ferritin of 500 ng/mL or more as well as the use of chemotherapy regimens besides CHOP-like or RCHOP, a high-intermediate/high risk IPI, and a high level of beta2-microglobulin in NHL may be an important marker for predicting poor survival outcomes.},\n\tnumber = {1},\n\tjournal = {Clinical lymphoma, myeloma \\& leukemia},\n\tauthor = {Yoh, Kyung Ah and Lee, Ho Sup and Park, Lee Chun and Lee, Eun Mi and Shin, Seong Hoon and Park, Dae Jin and Ye, Byeong Jin and Kim, Yang Soo},\n\tmonth = feb,\n\tyear = {2014},\n\tpmid = {24200518},\n\tkeywords = {Adolescent, Adult, Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols, Disease-Free Survival, Female, Ferritins, Humans, Lymphoma, Non-Hodgkin, Male, Middle Aged, Prognosis, Survival Rate},\n\tpages = {43--49}\n}\n\n","author_short":["Yoh, K. 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