Pattern classification using principal components of cortical thickness and its discriminative pattern in schizophrenia. Yoon, U., Lee, J., Im, K., Shin, Y., Cho, B. H., Kim, I. Y., Kwon, J. S., & Kim, S. I. Neuroimage, 34(4):1405--1415, February, 2007. ![Pattern classification using principal components of cortical thickness and its discriminative pattern in schizophrenia [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper abstract bibtex We proposed pattern classification based on principal components of cortical thickness between schizophrenic patients and healthy controls, which was trained using a leave-one-out cross-validation. The cortical thickness was measured by calculating the Euclidean distance between linked vertices on the inner and outer cortical surfaces. Principal component analysis was applied to each lobe for practical computational issues and stability of principal components. And, discriminative patterns derived at every vertex in the original feature space with respect to support vector machine were analyzed with definitive findings of brain abnormalities in schizophrenia for establishing practical confidence. It was simulated with 50 randomly selected validation set for the generalization and the average accuracy of classification was reported. This study showed that some principal components might be more useful than others for classification, but not necessarily matching the ordering of the variance amounts they explained. In particular, 40-70 principal components rearranged by a simple two-sample t-test which ranked the effectiveness of features were used for the best mean accuracy of simulated classification (frontal: (left(%)right(%)) = 91.0788.80, parietal: 91.4091.53, temporal: 93.6091.47, occipital: 88.8091.60). And, discriminative power appeared more spatially diffused bilaterally in the several regions, especially precentral, postcentral, superior frontal and temporal, cingulate and parahippocampal gyri. Since our results of discriminative patterns derived from classifier were consistent with a previous morphological analysis of schizophrenia, it can be said that the cortical thickness is a reliable feature for pattern classification and the potential benefits of such diagnostic tools are enhanced by our finding.
@Article{Yoon2007,
author = {Yoon, Uicheul and Lee, Jong-Min and Im, Kiho and Shin, Yong-Wook and Cho, Baek Hwan and Kim, In Young and Kwon, Jun Soo and Kim, Sun I.},
title = {{Pattern classification using principal components of cortical thickness and its discriminative pattern in schizophrenia}},
journal = {Neuroimage},
year = {2007},
volume = {34},
number = {4},
pages = {1405--1415},
month = feb,
abstract = {We proposed pattern classification based on principal components of cortical thickness between schizophrenic patients and healthy controls, which was trained using a leave-one-out cross-validation. The cortical thickness was measured by calculating the Euclidean distance between linked vertices on the inner and outer cortical surfaces. Principal component analysis was applied to each lobe for practical computational issues and stability of principal components. And, discriminative patterns derived at every vertex in the original feature space with respect to support vector machine were analyzed with definitive findings of brain abnormalities in schizophrenia for establishing practical confidence. It was simulated with 50 randomly selected validation set for the generalization and the average accuracy of classification was reported. This study showed that some principal components might be more useful than others for classification, but not necessarily matching the ordering of the variance amounts they explained. In particular, 40-70 principal components rearranged by a simple two-sample t-test which ranked the effectiveness of features were used for the best mean accuracy of simulated classification (frontal: (left(\%)right(\%)) = 91.0788.80, parietal: 91.4091.53, temporal: 93.6091.47, occipital: 88.8091.60). And, discriminative power appeared more spatially diffused bilaterally in the several regions, especially precentral, postcentral, superior frontal and temporal, cingulate and parahippocampal gyri. Since our results of discriminative patterns derived from classifier were consistent with a previous morphological analysis of schizophrenia, it can be said that the cortical thickness is a reliable feature for pattern classification and the potential benefits of such diagnostic tools are enhanced by our finding.},
issn = {1053-8119},
keywords = {Magnetic resonance imaging; Cortical thickness; Principal component analysis; Support vector machine; Leave-one-out cross-validation},
owner = {imagenes2},
timestamp = {2009.02.12},
url = {http://www.sciencedirect.com/science/article/B6WNP-4MNHY2V-5/2/0edbcd5786b3f7bc50a02d54c21bc7a0}
}
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The cortical thickness was measured by calculating the Euclidean distance between linked vertices on the inner and outer cortical surfaces. Principal component analysis was applied to each lobe for practical computational issues and stability of principal components. And, discriminative patterns derived at every vertex in the original feature space with respect to support vector machine were analyzed with definitive findings of brain abnormalities in schizophrenia for establishing practical confidence. It was simulated with 50 randomly selected validation set for the generalization and the average accuracy of classification was reported. This study showed that some principal components might be more useful than others for classification, but not necessarily matching the ordering of the variance amounts they explained. 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