Abnormal early stages of task stimulus processing in children with attention-deficit hyperactivity disorder--evidence from event-related gamma oscillations. Yordanova, J., Banaschewski, T., Kolev, V., Woerner, W., & Rothenberger, A. Clin Neurophysiol, 112(6):1096-108, 2001.
abstract   bibtex   
Institute of Physiology, Bulgarian Academy of Sciences, Acad. G. Bonchev str., bl. 23, 1113, Sofia, Bulgaria. OBJECTIVES: Attention-related differences in early stages of stimulus processing were assessed in healthy controls and children with attention-deficit hyperactivity disorder (ADHD) by analyzing phase-locked gamma band (31-63 Hz) responses to auditory stimuli in a selective-attention task. METHODS: A total of 28 children aged 9-12 years (ADHD and matched healthy controls) pressed a button in response to each target stimulus presented at the attended side (right or left). Auditory gamma band responses (GBRs) within 0-120 ms were analyzed at 8 electrodes with wavelet transform. Effects of attended channel, stimulus type, and group were evaluated for GBR power and phase-locking. RESULTS: For both groups, GBRs had a frontal-central distribution, were significantly larger and more strongly phase-locked to target than to non-target stimuli, and did not differentiate the attended from the unattended channel. ADHD children produced larger and more strongly phase-locked GBRs than controls only to right-side stimuli, irrespective of whether these were the attended or the ignored stimuli. CONCLUSIONS: The association between auditory GBR and motor task stimulus in children suggests that phase-locked gamma oscillations may reflect processes of sensory-motor integration. ADHD-related deviations of GBRs indicate that early mechanisms of auditory stimulus processing are altered in ADHD, presumably as a result of impaired motor inhibition.
@article{ Yordanova_etal01,
  author = {Yordanova, J. and Banaschewski, T. and Kolev, V. and Woerner, W.
	and Rothenberger, A.},
  title = {Abnormal early stages of task stimulus processing in children with
	attention-deficit hyperactivity disorder--evidence from event-related
	gamma oscillations},
  journal = {Clin Neurophysiol},
  year = {2001},
  volume = {112},
  pages = {1096-108},
  number = {6},
  abstract = {Institute of Physiology, Bulgarian Academy of Sciences, Acad. G. Bonchev
	str., bl. 23, 1113, Sofia, Bulgaria. 
	
	OBJECTIVES: Attention-related differences in early stages of stimulus
	processing were assessed in healthy controls and children with attention-deficit
	hyperactivity disorder (ADHD) by analyzing phase-locked gamma band
	(31-63 Hz) responses to auditory stimuli in a selective-attention
	task. METHODS: A total of 28 children aged 9-12 years (ADHD and matched
	healthy controls) pressed a button in response to each target stimulus
	presented at the attended side (right or left). Auditory gamma band
	responses (GBRs) within 0-120 ms were analyzed at 8 electrodes with
	wavelet transform. Effects of attended channel, stimulus type, and
	group were evaluated for GBR power and phase-locking. RESULTS: For
	both groups, GBRs had a frontal-central distribution, were significantly
	larger and more strongly phase-locked to target than to non-target
	stimuli, and did not differentiate the attended from the unattended
	channel. ADHD children produced larger and more strongly phase-locked
	GBRs than controls only to right-side stimuli, irrespective of whether
	these were the attended or the ignored stimuli. CONCLUSIONS: The
	association between auditory GBR and motor task stimulus in children
	suggests that phase-locked gamma oscillations may reflect processes
	of sensory-motor integration. ADHD-related deviations of GBRs indicate
	that early mechanisms of auditory stimulus processing are altered
	in ADHD, presumably as a result of impaired motor inhibition. }
}

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